<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0035-0052</journal-id>
<journal-title><![CDATA[Revista mexicana de pediatría]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. pediatr.]]></abbrev-journal-title>
<issn>0035-0052</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Pediatría A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0035-00522021000300101</article-id>
<article-id pub-id-type="doi">10.35366/102190</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Esclerosis múltiple en pediatría. Presentación de dos casos]]></article-title>
<article-title xml:lang="en"><![CDATA[Multiple sclerosis in pediatrics. Presentation of two cases]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Padilla]]></surname>
<given-names><![CDATA[Julio César]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Astorga-Chávez]]></surname>
<given-names><![CDATA[María de Lourdes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mandujano-Trejo]]></surname>
<given-names><![CDATA[María Guadalupe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Clínica Cuauhtémoc Servicio de Transporte Colectivo Metro ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Sanatorio Durango  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>88</volume>
<numero>3</numero>
<fpage>101</fpage>
<lpage>107</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0035-00522021000300101&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0035-00522021000300101&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0035-00522021000300101&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Objetivo:  Describir dos pacientes adolescentes con esclerosis múltiple, la cual es una enfermedad desmielinizante del sistema nervioso central. Presentación de los casos: El primer caso se trató de una paciente de 14 años con sobrepeso, con un padecimiento caracterizado por mareo, cefalea, parestesias en miembros inferiores, diplopía y bradilalia. A la exploración, datos compatibles de afectación a nivel cerebeloso. En estudio de imagen de resonancia magnética (IRM) de cráneo se evidencia áreas de desmielinización en fosa posterior. Se diagnostica esclerosis múltiple de variedad remitente recurrente. Con la administración de esteroides e interferón beta hubo mejoría de sintomatología. Segundo caso: femenino de 13 años de edad, quien presenta caída de propia altura, incontinencia de esfínter vesical, pérdida de fuerza en brazo y pierna izquierdas. En la exploración física, hemiparesia izquierda. IRM: datos de desmielinización en ventrículo lateral, cerebelo y médula espinal. La paciente mejoró al iniciar esteroides e interferón.  Conclusiones:  La presentación clínica de la esclerosis múltiple en pacientes pediátricos es un reto, ya que es un padecimiento que tienen manifestaciones poco específicas. Para establecer el diagnóstico se requiere realizar múltiples estudios. El pronóstico puede ser más favorable entre más temprano se inicie el tratamiento.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Objective:  We describe two adolescent patients with multiple sclerosis, which is a demyelinating disease of the central nervous system. Presentation of the cases: The first case was a 14-year-old female patient with overweight; her condition was characterized by dizziness, headache, paresthesia in the lower limbs, diplopia and bradylalia. On physical examination, compatible data of cerebellar involvement were identified. A magnetic resonance imaging (MRI) of the skull showed areas of demyelination in the posterior fossa. Multiple sclerosis, the relapsing-remitting variety, is diagnosed. After the administration of steroids and beta interferon, there was improvement in symptoms. Second case: 13-year-old female, who presented fall from her own height, bladder incontinence, loss of strength in the left arm and leg. On physical examination, left hemiparesis was detected. MRI: demyelination data in lateral ventricle, cerebellum and spinal cord. The patient improved after starting steroids and interferon.  Conclusions:  The clinical presentation of multiple sclerosis in pediatric patients is a challenge, since it is a condition with unspecific manifestations. Establishing the diagnosis requires multiple studies. The earlier treatment is started, the more favorable the prognosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Esclerosis múltiple]]></kwd>
<kwd lng="es"><![CDATA[enfermedad desmielinizante]]></kwd>
<kwd lng="es"><![CDATA[alteraciones neurológicas]]></kwd>
<kwd lng="es"><![CDATA[resonancia magnética]]></kwd>
<kwd lng="es"><![CDATA[adolescentes]]></kwd>
<kwd lng="en"><![CDATA[Multiple sclerosis]]></kwd>
<kwd lng="en"><![CDATA[demyelinating disease]]></kwd>
<kwd lng="en"><![CDATA[neurological manifestations]]></kwd>
<kwd lng="en"><![CDATA[magnetic resonance]]></kwd>
<kwd lng="en"><![CDATA[adolescents]]></kwd>
</kwd-group>
</article-meta>
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<article-title xml:lang=""><![CDATA[Therapeutic approach to the management of pediatric demyelinating disease: multiple sclerosis and acute disseminated encephalomyelitis]]></article-title>
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