<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0035-0052</journal-id>
<journal-title><![CDATA[Revista mexicana de pediatría]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. pediatr.]]></abbrev-journal-title>
<issn>0035-0052</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Pediatría A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0035-00522019000400155</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de Fraser: reporte de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Fraser syndrome: a case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bustillo-Sierra]]></surname>
<given-names><![CDATA[Clara Melissa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarenga-Calidonio]]></surname>
<given-names><![CDATA[Ramón Humberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de Honduras  ]]></institution>
<addr-line><![CDATA[Tegucigalpa ]]></addr-line>
<country>Honduras</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>86</volume>
<numero>4</numero>
<fpage>155</fpage>
<lpage>158</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0035-00522019000400155&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0035-00522019000400155&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0035-00522019000400155&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  El síndrome de Fraser es una enfermedad autosómica recesiva, con una frecuencia de 0.2/100,000 nacidos vivos. Múltiples genes se han visto implicados, por lo que su expresión clínica es muy variable.  Caso clínico:  Paciente femenino, producto de segunda gestación, que nace con dificultad respiratoria y múltiples malformaciones. Padre de 20 años y madre de 18, niegan consanguinidad. Al examen físico, taquipnea, estridor inspiratorio, saturación de oxígeno al 68%, se detectó microcefalia, criptoftalmos bilateral, hipoplasia nasal, hernia umbilical, hipertrofia del clítoris, atresia vaginal y sindactilia parcial. Ecocardiograma: comunicación interventricular. Ultrasonido abdominal: presencia de vestigios mullerianos. TAC: ausencia de globos oculares. Nasofibroscopía: estenosis subglótica. Falleció al mes de vida.  Conclusiones:  El pronóstico de estos pacientes es malo, por lo que el asesoramiento genético es fundamental.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  Fraser syndrome is an autosomal recessive disease, with a frequency of 0.2 / 100,000 live births. Multiple genes have been implicated, so their clinical expression is highly variable.  Case report:  Female patient; she was born with respiratory distress and multiple malformations. Mother was 18 years-old and father 20 years-old. Consanguinity was denied. On physical examination, tachypnea, inspiratory stridor, 68% oxygen saturation, microcephaly, bilateral cryptophthalmos, nasal hypoplasia, umbilical hernia, clitoris hypertrophy, vaginal atresia and partial syndactyly were detected. Echocardiogram: interventricular communication; abdominal ultrasound: presence of mullerian vestiges. CT: absence of eyeballs. Nasofibroscopy: subglottic stenosis. She died at 30 days old.  Conclusions:  Prognosis of patients with Fraser syndrome is bad, so genetic counseling is essential.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome de Fraser]]></kwd>
<kwd lng="es"><![CDATA[criptoftalmos]]></kwd>
<kwd lng="es"><![CDATA[sindactilia]]></kwd>
<kwd lng="en"><![CDATA[Fraser syndrome]]></kwd>
<kwd lng="en"><![CDATA[crypthophtalmos]]></kwd>
<kwd lng="en"><![CDATA[syndactyly]]></kwd>
</kwd-group>
</article-meta>
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