<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0028-3746</journal-id>
<journal-title><![CDATA[Neumología y cirugía de tórax]]></journal-title>
<abbrev-journal-title><![CDATA[Neumol. cir. torax]]></abbrev-journal-title>
<issn>0028-3746</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Neumología y Cirugía de Tórax; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas; Sociedad Cubana de Neumología; Sociedad Paraguaya de Neumología; Sociedad Boliviana de Neumología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0028-37462018000400297</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Determinantes de patogenicidad en el virus de influenza pandémico en México: Factores virales asociados con la severidad]]></article-title>
<article-title xml:lang="en"><![CDATA[Determinants of pathogenicity in pandemic influenza virus in Mexico: viral factors associated with severity]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mejía-Nepomuceno]]></surname>
<given-names><![CDATA[Fidencio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Maldonado]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Padilla]]></surname>
<given-names><![CDATA[Rogelio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vázquez-Pérez]]></surname>
<given-names><![CDATA[Joel Armando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>77</volume>
<numero>4</numero>
<fpage>297</fpage>
<lpage>304</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0028-37462018000400297&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0028-37462018000400297&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0028-37462018000400297&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El virus de influenza causa por lo común infecciones estacionales y ocasionalmente pandemias, provocando un aumento en la morbimortalidad de las enfermedades respiratorias en los humanos. El virus de influenza tiene la habilidad de adaptarse a varios hospederos, circulando de manera normal y constante en aves acuáticas, aves de corral, cerdos, caballos y humanos. La interacción de diferentes subtipos virales en estos hospederos puede generar nuevas variantes. Aunado a esto se presentan de forma natural mutaciones puntuales en todos los genes del virus, que pueden conferir ventajas en la replicación viral, adaptación, así como en la evasión del sistema inmunológico, emergiendo variantes virales con la probabilidad de ser más patogénicos. Caracterizar los determinantes de patogenicidad permite monitorear y detectar de manera temprana aquellas posibles cepas que puedan generar una amenaza en la población humana, contribuyendo con esto en la identificación molecular de los posibles cambios en el genoma del virus de influenza, correlacionándola con la virulencia y la patogenicidad del virus.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: The influenza virus often causes seasonal infections and occasionally pandemics which increase the level morbidity and mortality of respiratory diseases in humans. The influenza virus is capable of adapting to several hosts while circulating in a normal and constant manner in aquatic birds, poultry, pigs, horses and humans. Interaction between different viral subtypes in these hosts can generate new variants. In addition, point mutations naturally occur in all genes of the virus, which may confer advantages to viral replication, adaptation and evasion of the immune system, and allow viral isolates the probability of being more pathogenic. Characterization of the determinants of pathogenicity, allow monitoring and detecting possible strains at an early stage that may pose a threat to the human population. This will also contribute to identify possible molecular changes in the influenza virus genome, and to correlate these changes to the virulence and pathogenicity of the virus.]]></p></abstract>
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<kwd lng="es"><![CDATA[Determinantes de patogenicidad]]></kwd>
<kwd lng="es"><![CDATA[influenza H1N1pdm09]]></kwd>
<kwd lng="es"><![CDATA[caracterización]]></kwd>
<kwd lng="en"><![CDATA[Determinants of pathogenicity]]></kwd>
<kwd lng="en"><![CDATA[influenza A H1N1pdm09]]></kwd>
<kwd lng="en"><![CDATA[characterization]]></kwd>
</kwd-group>
</article-meta>
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