<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3813</journal-id>
<journal-title><![CDATA[Gaceta médica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. Méd. Méx]]></abbrev-journal-title>
<issn>0016-3813</issn>
<publisher>
<publisher-name><![CDATA[Academia Nacional de Medicina de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-38132023000300215</article-id>
<article-id pub-id-type="doi">10.24875/gmm.22000373</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Complicaciones tromboembólicas y hemorrágicas en pacientes portadores de prótesis valvulares del corazón en un centro de tercer nivel. ¿Qué hemos aprendido?]]></article-title>
<article-title xml:lang="en"><![CDATA[Thromboembolic and hemorrhagic complications in patients with prosthetic heart valves at third level care center. What have we learned?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Medina]]></surname>
<given-names><![CDATA[Fernando F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valenzuela-Antelo]]></surname>
<given-names><![CDATA[Olivia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valenzuela-Molina]]></surname>
<given-names><![CDATA[Lucía C,]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arias-Martínez]]></surname>
<given-names><![CDATA[Joel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Morales]]></surname>
<given-names><![CDATA[Cruz M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ornelas-Aguirre]]></surname>
<given-names><![CDATA[José M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Centro Médico Nacional del Noroeste Servicio de Cirugía Cardiotorácica]]></institution>
<addr-line><![CDATA[Ciudad Obregón Sonora]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Sonora Departamento de Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Centro Médico Nacional del Noroeste Unidad de Cuidados Intensivos]]></institution>
<addr-line><![CDATA[Ciudad Obregón Sonora]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Sonora Departamento de Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Ciudad Obregón Sonora]]></addr-line>
<country>México</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Delegación Estatal del Instituto Mexicano del Seguro Social Servicio de Medicina Familiar ]]></institution>
<addr-line><![CDATA[Mexicali Baja California]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<volume>159</volume>
<numero>3</numero>
<fpage>215</fpage>
<lpage>223</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0016-38132023000300215&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0016-38132023000300215&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0016-38132023000300215&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: El reemplazo valvular por prótesis mecánicas o biológicas implica riesgo de tromboembolismo y complicaciones hemorrágicas.  Objetivo: Determinar las complicaciones relacionadas con la terapia de anticoagulación complementaria y la probabilidad de riesgo en pacientes portadores de prótesis valvulares del corazón.  Métodos: Se estudiaron 163 pacientes entre 2002 y 2016, portadores de prótesis mecánicas y biológicas, quienes recibieron antagonistas de la vitamina K posterior al egreso hospitalario. La terapia de anticoagulación se categorizó en óptima y no óptima conforme a los valores de INR previos a las complicaciones. Fueron excluidos los pacientes con comorbilidades y otros factores de riesgo de trombosis y/o sangrado.  Resultados: a 68.7 % de los pacientes se les colocó prótesis mecánica y a 31.3 %, biológica (p &#8804; 0.001); 25.2 % presentó las complicaciones motivo de estudio (p &#8804; 0.001), hemorrágicas en 48.8 %, tromboembólicas en 26.8 % y de ambos tipos en 24.4 % (riesgo relativo = 4.229); a 95.1 % de los pacientes con complicaciones se les colocó prótesis mecánica y a 4.9 %, biológica (p = 0.005); 49.7 % presentó INR no óptimo (p &#8804; 0.001).  Conclusiones: Ante riesgo alto de complicaciones tromboembólicas y hemorrágicas, la elección de las prótesis valvulares, la prevención y el seguimiento son prioridades, principalmente en quienes requieren terapia de anticoagulación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Heart valve replacement surgery with mechanical or biological prostheses entails a risk of thromboembolism and bleeding complications.  Objective: To determine the complications related to complementary anticoagulation therapy and the probability of risk.  Methods: One-hundred and sixty-three patients who underwent heart valve replacement between 2002 and 2016 with either mechanical or biological prostheses, and who received vitamin K antagonists after hospital discharge, were studied. Anticoagulation therapy was categorized into optimal and non-optimal according to INR values prior to the development of complications. Patients with comorbidities and other risk factors for thrombosis and/or bleeding were excluded.  Results: In total, 68.7 % of patients received mechanical prostheses, and 31.3 %, biological prostheses (p &#8804; 0.001); 25.2 % experienced the complications that motivated the study (p &#8804; 0.001), which were hemorrhagic in 48.8 %, thromboembolic in 26.8 %, and of both types in 24.4 % (relative risk = 4.229). Among the patients with complications, 95.1 % received mechanical prostheses, and 4.9 %, biological (p = 0.005); non-optimal INR was identified in 49.7 % (p &#8804; 0.001).  Conclusions: Given the high risk of thromboembolic and hemorrhagic complications, valve prostheses must be carefully chosen, and care priorities should include prevention and follow-up, especially in those patients who require anticoagulation therapy.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Complicaciones hemorrágicas]]></kwd>
<kwd lng="es"><![CDATA[Complicaciones tromboembólicas]]></kwd>
<kwd lng="es"><![CDATA[Deterioro valvular estructural]]></kwd>
<kwd lng="es"><![CDATA[Prótesis valvulares del corazón]]></kwd>
<kwd lng="es"><![CDATA[Terapia de anticoagulación]]></kwd>
<kwd lng="es"><![CDATA[Trombosis valvular protésica]]></kwd>
<kwd lng="en"><![CDATA[Bleeding complications]]></kwd>
<kwd lng="en"><![CDATA[Thromboembolic complications]]></kwd>
<kwd lng="en"><![CDATA[Structural valve deterioration]]></kwd>
<kwd lng="en"><![CDATA[Heart valve prostheses]]></kwd>
<kwd lng="en"><![CDATA[Anticoagulation therapy]]></kwd>
<kwd lng="en"><![CDATA[Prosthetic valve thrombosis]]></kwd>
</kwd-group>
</article-meta>
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