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<front>
<journal-meta>
<journal-id>0016-3813</journal-id>
<journal-title><![CDATA[Gaceta médica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. Méd. Méx]]></abbrev-journal-title>
<issn>0016-3813</issn>
<publisher>
<publisher-name><![CDATA[Academia Nacional de Medicina de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-38132022001300028</article-id>
<article-id pub-id-type="doi">10.24875/gmm.m22000666</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Mielofibrosis: diagnóstico y tratamiento]]></article-title>
<article-title xml:lang="en"><![CDATA[Myelofibrosis: diagnosis and treatment]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Castro]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barranco-Lampón]]></surname>
<given-names><![CDATA[Gilberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arana-Luna]]></surname>
<given-names><![CDATA[Luara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez-Vera]]></surname>
<given-names><![CDATA[José L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-Castillejos]]></surname>
<given-names><![CDATA[Flavio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peñaloza-Ramírez]]></surname>
<given-names><![CDATA[Rosalinda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carballo-Zarate]]></surname>
<given-names><![CDATA[Adrián A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Olarte-Carrillo]]></surname>
<given-names><![CDATA[Irma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Minamy]]></surname>
<given-names><![CDATA[Jaime Israel-García]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Salazar]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Navarrete]]></surname>
<given-names><![CDATA[Juan J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Espinosa-Partida]]></surname>
<given-names><![CDATA[Arturo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ventura-Enríquez]]></surname>
<given-names><![CDATA[Yanet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A12"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz-Contreras]]></surname>
<given-names><![CDATA[Josué I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguirre-Reyes]]></surname>
<given-names><![CDATA[Oyuky G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Anaya-Cuéllar]]></surname>
<given-names><![CDATA[Irene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilar-Luévano]]></surname>
<given-names><![CDATA[Jocelyn]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Ramírez]]></surname>
<given-names><![CDATA[Hugo F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Herrera-Olivares]]></surname>
<given-names><![CDATA[Wilfrido]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilar-Hidalgo]]></surname>
<given-names><![CDATA[José A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alcívar-Cedeño]]></surname>
<given-names><![CDATA[Luisa Ma.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Caballero]]></surname>
<given-names><![CDATA[Álvaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Galaz-Cordero]]></surname>
<given-names><![CDATA[Lourdes Elena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[de la Peña-Celaya]]></surname>
<given-names><![CDATA[José A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Báez-Islas]]></surname>
<given-names><![CDATA[Pamela Elena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bates-Martín]]></surname>
<given-names><![CDATA[Ramón A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[de la Luz Cano-León]]></surname>
<given-names><![CDATA[Ana Ma.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Espitia-Ríos]]></surname>
<given-names><![CDATA[Ma. Eugenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barbosa]]></surname>
<given-names><![CDATA[Diego]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales-Adrián]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pacheco]]></surname>
<given-names><![CDATA[Martín J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Delgado-López]]></surname>
<given-names><![CDATA[Nancy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Neme-Yunes]]></surname>
<given-names><![CDATA[Yvette]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales-Hernández]]></surname>
<given-names><![CDATA[Alba E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mújica-Martínez]]></surname>
<given-names><![CDATA[Aldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Lizardi]]></surname>
<given-names><![CDATA[Alejandra B.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Gómez]]></surname>
<given-names><![CDATA[Karen D.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barragán-Ibáñez]]></surname>
<given-names><![CDATA[Gabriel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[Adolfo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores-Ordúñez]]></surname>
<given-names><![CDATA[Karen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-Hoyos]]></surname>
<given-names><![CDATA[Paulina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosales-López]]></surname>
<given-names><![CDATA[Ma. de los Ángeles]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acosta-Maldonado]]></surname>
<given-names><![CDATA[Brenda L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez-Ochoa]]></surname>
<given-names><![CDATA[Marco A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garzón-Velásquez]]></surname>
<given-names><![CDATA[Katheryn B.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Ruiz]]></surname>
<given-names><![CDATA[Eleazar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[McNally-Guillén]]></surname>
<given-names><![CDATA[Bosco M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Saucedo-Montes]]></surname>
<given-names><![CDATA[Erick E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilar-Andrade]]></surname>
<given-names><![CDATA[Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A36"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vivas-Arteaga]]></surname>
<given-names><![CDATA[Cindy L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guerra-Alarcón]]></surname>
<given-names><![CDATA[Lidia V.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Milán-Salvatierra]]></surname>
<given-names><![CDATA[Andrea I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Campa-Monroy]]></surname>
<given-names><![CDATA[Dafne I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cota-Rangel]]></surname>
<given-names><![CDATA[Xóchitl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Estrada-Domínguez]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Camacho]]></surname>
<given-names><![CDATA[Alinka S.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A0"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Castillo]]></surname>
<given-names><![CDATA[Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Banda-García]]></surname>
<given-names><![CDATA[Luisa I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Sánchez]]></surname>
<given-names><![CDATA[Vania]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meillón-García]]></surname>
<given-names><![CDATA[Luis A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Urbina-Escalante]]></surname>
<given-names><![CDATA[Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Ramírez]]></surname>
<given-names><![CDATA[Mario A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Loera-Fragoso]]></surname>
<given-names><![CDATA[Sergio J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Coronel]]></surname>
<given-names><![CDATA[Jorge]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zapata-Canto]]></surname>
<given-names><![CDATA[Nidia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A5"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Cortés]]></surname>
<given-names><![CDATA[Sue C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medina-Coral]]></surname>
<given-names><![CDATA[Jesús E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mojica-Balderas]]></surname>
<given-names><![CDATA[Liliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Zúñiga]]></surname>
<given-names><![CDATA[Juan M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[Fernando J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Arroyo]]></surname>
<given-names><![CDATA[José L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zazueta-Pozos]]></surname>
<given-names><![CDATA[Juan F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero-Martínez]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero-Rodelo]]></surname>
<given-names><![CDATA[Hilda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tapia-Enríquez]]></surname>
<given-names><![CDATA[Ana L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soriano-Mercedes]]></surname>
<given-names><![CDATA[Emely J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salazar-Ramírez]]></surname>
<given-names><![CDATA[Óscar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vilchis-González]]></surname>
<given-names><![CDATA[Shendel Paulina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tepepa-Flores]]></surname>
<given-names><![CDATA[Fredy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarado-Ibarra]]></surname>
<given-names><![CDATA[Martha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de Especialidades Centro Médico Nacional Siglo XXI Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital General de México Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Cancerología Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Hospital General de Zona No. 2 Servicio de Hematología]]></institution>
<addr-line><![CDATA[Salina Cruz Oax]]></addr-line>
<country>México</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Hospital de Alta Especialidad de Oaxaca Servicio de Hematopatología ]]></institution>
<addr-line><![CDATA[Oaxaca Oax]]></addr-line>
<country>México</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Hospital Español de México Servicio de Hematopatología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,Hospital General de México Biología molecular ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af9">
<institution><![CDATA[,Hospital General de México Servicio de Hematopatología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A10">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Hospital General Belisario Domínguez Servicio de Hematología]]></institution>
<addr-line><![CDATA[Tuxtla Gutiérrez Chis]]></addr-line>
<country>México</country>
</aff>
<aff id="A11">
<institution><![CDATA[,Hospital Centro Médico Naval Banco de Sangre ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A12">
<institution><![CDATA[,Hospital Centro Médico Naval Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A13">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Ciudad Juárez Servicio de Hematología ]]></institution>
<addr-line><![CDATA[Ciudad Juárez Chih]]></addr-line>
<country>México</country>
</aff>
<aff id="A14">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Hospital General Presidente Lázaro Cárdenas Servicio de Hematología]]></institution>
<addr-line><![CDATA[Chihuahua Chih]]></addr-line>
<country>México</country>
</aff>
<aff id="A15">
<institution><![CDATA[,Hospital H+ Querétaro Servicio de Hematología ]]></institution>
<addr-line><![CDATA[Querétaro Qro]]></addr-line>
<country>México</country>
</aff>
<aff id="A16">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Hospital Regional de Puebla Servicio de Hematología]]></institution>
<addr-line><![CDATA[Puebla Pue]]></addr-line>
<country>México</country>
</aff>
<aff id="A17">
<institution><![CDATA[,Grupo Médico Móvil Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="A18">
<institution><![CDATA[,Hospital de Especialidades Unidad Médica de Alta Especialidad Servicio de Hematología]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A19">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Servicio de Hematología ]]></institution>
<addr-line><![CDATA[Hermosillo Son]]></addr-line>
<country>México</country>
</aff>
<aff id="A20">
<institution><![CDATA[,Hospital Regional 1 de Octubre Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A21">
<institution><![CDATA[,Hospital General Regional No. 1 Instituto Mexicano del Seguro Social Servicio de Hematología]]></institution>
<addr-line><![CDATA[Querétaro Qro]]></addr-line>
<country>México</country>
</aff>
<aff id="A22">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estad Hospital Regional de Mérida Servicio de Hematología]]></institution>
<addr-line><![CDATA[Mérida Yuc]]></addr-line>
<country>México</country>
</aff>
<aff id="A23">
<institution><![CDATA[,Centro Médico ABC Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A24">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Hospital General de Zona No. 27 Servicio de Hematología]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A25">
<institution><![CDATA[,Hospital General de Zona No. 1 Hospital Instituto Mexicano del Seguro Social Chihuahua Servicio de Hematología]]></institution>
<addr-line><![CDATA[Chihuahua Chih]]></addr-line>
<country>México</country>
</aff>
<aff id="A26">
<institution><![CDATA[,Servicio de Hematología del Hospital Regional de Alta Especialidad de Oaxaca Servicio de Hematología del Hospital Regional de Alta Especialidad de Oaxaca ]]></institution>
<addr-line><![CDATA[Oaxaca ]]></addr-line>
<country>México</country>
</aff>
<aff id="A27">
<institution><![CDATA[,Hospital General de México Laboratorio de Hematología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A28">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Hospital General de Zona No. 24 Servicio de Hematología]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A29">
<institution><![CDATA[,Hospital Español de México Medicina Interna ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A30">
<institution><![CDATA[,Instituto Nacional de Cancerología Unidad de trasplante de médula ósea ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A31">
<institution><![CDATA[,Hospital de Especialidades Centro Médico Nacional Siglo XXI Unidad de trasplante de médula ósea ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A32">
<institution><![CDATA[,Instituto Nacional de Cancerología Medicina transfusional ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A33">
<institution><![CDATA[,Centro Médico de Especialidades Trasplante de médula ósea Servicio de Hematología]]></institution>
<addr-line><![CDATA[Ciudad Juárez Chih]]></addr-line>
<country>México</country>
</aff>
<aff id="A34">
<institution><![CDATA[,Hospital General Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Tampico Banco de Sangre ]]></institution>
<addr-line><![CDATA[Tampico Tamps]]></addr-line>
<country>México</country>
</aff>
<aff id="A35">
<institution><![CDATA[,Instituto Nacional de Cardiología Banco de Sangre ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A36">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Carlos MacGregor Hospitalización ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A37">
<institution><![CDATA[,Grupo CREHO Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Guatemala</country>
</aff>
<aff id="A38">
<institution><![CDATA[,Hospital Juárez de México Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A39">
<institution><![CDATA[,San Telmo Medical Center Servicio de Hematología ]]></institution>
<addr-line><![CDATA[Aguascalientes Ags]]></addr-line>
<country>México</country>
</aff>
<aff id="A40">
<institution><![CDATA[,Oncología Integral Satélite Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ Estado de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A41">
<institution><![CDATA[,Hospital Central Militar Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A42">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Hospital Regional B Servicio de Hematología]]></institution>
<addr-line><![CDATA[Veracruz Ver]]></addr-line>
<country>México</country>
</aff>
<aff id="A43">
<institution><![CDATA[,Hospital Santiago Ramon y Cajal de Durango Servicio de Hematología ]]></institution>
<addr-line><![CDATA[Durango Dgo]]></addr-line>
<country>México</country>
</aff>
<aff id="A44">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Hospital Regional Valentín Gómez Farías Servicio de Hematología]]></institution>
<addr-line><![CDATA[Guadalajara Jal]]></addr-line>
<country>México</country>
</aff>
<aff id="A45">
<institution><![CDATA[,Servicio de Hematología Servicio de Hematología ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A46">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Dr. Manuel Cárdenas de la Vega Servicio de Hematología ]]></institution>
<addr-line><![CDATA[Culiacán Sin]]></addr-line>
<country>México</country>
</aff>
<aff id="A47">
<institution><![CDATA[,Hospital Universitario Martín Dockweiler Servicio de Hematología ]]></institution>
<addr-line><![CDATA[Santa Cruz ]]></addr-line>
<country>Bolivia</country>
</aff>
<aff id="A48">
<institution><![CDATA[,PEMEX Hospital Central Norte Servicio de Hematología]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A49">
<institution><![CDATA[,Servicio de Hematología Servicio de Hematología ]]></institution>
<addr-line><![CDATA[Mexicali B.C]]></addr-line>
<country>México</country>
</aff>
<aff id="A50">
<institution><![CDATA[,Hospital Fray Junípero Serra Servicio de Hematología ]]></institution>
<addr-line><![CDATA[Tijuana B.C]]></addr-line>
<country>México</country>
</aff>
<aff id="A51">
<institution><![CDATA[,Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Hospital General Dr. Darío Fernández Fierro Servicio de Hematología]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="A52">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Hospital General Regional No. 2 Servicio de Hematología]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>158</volume>
<fpage>28</fpage>
<lpage>39</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0016-38132022001300028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0016-38132022001300028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0016-38132022001300028&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[resumen está disponible en el texto completo]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Myelofibrosis (MF) is a BCR-ABL1-negative myeloproliferative neoplasm characterized by clonal myeloproliferation, dysregulated kinase signaling, and release of abnormal cytokines. In recent years, important progress has been made in the knowledge of the molecular biology and the prognostic assessment of MF. Conventional treatment has limited impact on the patients’ survival; it includes a wait-and-see approach for asymptomatic patients, erythropoiesis-stimulating agents, androgens, or immunomodulatory agents for anemia, cytoreductive drugs such as hydroxyurea for the splenomegaly and constitutional symptoms, and splenectomy or radiotherapy in selected patients. The discovery of the Janus kinase (JAK)2 mutation triggered the development of molecular targeted therapy of MF. The JAK inhibitors are effective in both JAK2-positive and JAK2-negative MF; one of them, ruxolitinib, is the current best available therapy for MF splenomegaly and constitutional symptoms. However, although ruxolitinib has changed the therapeutic scenario of MF, there is no clear indication of a disease-modifying effect. Allogeneic stem cell transplantation remains the only curative therapy of MF, but due to its associated morbidity and mortality, it is usually restricted to eligible high- and intermediate-2-risk MF patients. To improve current therapeutic results, the combination of JAK inhibitors with other agents is currently being tested, and newer drugs are being investigated.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Andrógenos]]></kwd>
<kwd lng="es"><![CDATA[Anemia]]></kwd>
<kwd lng="es"><![CDATA[Hidroxiurea]]></kwd>
<kwd lng="es"><![CDATA[Inhibidores de la cinasa de Janus]]></kwd>
<kwd lng="es"><![CDATA[Mielofibrosis]]></kwd>
<kwd lng="es"><![CDATA[Radioterapia]]></kwd>
<kwd lng="en"><![CDATA[Androgens]]></kwd>
<kwd lng="en"><![CDATA[Anemia]]></kwd>
<kwd lng="en"><![CDATA[Hydroxyurea]]></kwd>
<kwd lng="en"><![CDATA[Janus kinase inhibitors]]></kwd>
<kwd lng="en"><![CDATA[Myelofibrosis]]></kwd>
<kwd lng="en"><![CDATA[Radiation therapy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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