<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3813</journal-id>
<journal-title><![CDATA[Gaceta médica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. Méd. Méx]]></abbrev-journal-title>
<issn>0016-3813</issn>
<publisher>
<publisher-name><![CDATA[Academia Nacional de Medicina de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-38132021000400385</article-id>
<article-id pub-id-type="doi">10.24875/gmm.20000742</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Deterioro cognoscitivo en pacientes con tuberculosis del sistema nervioso central]]></article-title>
<article-title xml:lang="en"><![CDATA[Cognitive impairment in patients with central nervous system tuberculosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Popoca-Rodríguez]]></surname>
<given-names><![CDATA[Ignacio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cárdenas]]></surname>
<given-names><![CDATA[Graciela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suarez" Unidad de Investigación Clínica Departamento de Neuroinfectología]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<volume>157</volume>
<numero>4</numero>
<fpage>385</fpage>
<lpage>390</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0016-38132021000400385&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0016-38132021000400385&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0016-38132021000400385&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La tuberculosis en México sigue siendo causa importante de morbimortalidad; en los últimos cuatro años, se reportaron 110 681 casos de tuberculosis pulmonar y 1571 casos de tuberculosis meníngea.  Objetivo: Determinar las secuelas neurocognoscitivas, presentación clínica y alteraciones en los estudios de neuroimagen en pacientes con tuberculosis del sistema nervioso central.  Métodos: Se realizó un estudio retrospectivo, analítico y transversal de 2010 a 2019. Se incluyeron pacientes con tuberculosis del sistema nervioso central, con y sin coinfección por VIH/sida.  Resultados: Durante el periodo de estudio se incluyeron 104 casos con diagnóstico definitivo y probable de tuberculosis del sistema nervioso central; de acuerdo con los criterios de Marais, 38 % presentó coinfección por VIH/sida y 55 %, diversas comorbilidades (p = 0.0001); 49 % presentó alteraciones cognoscitivas y 14 % falleció.  Conclusiones: Aunque la infección por VIH/sida puede contribuir al deterioro cognitivo del paciente con tuberculosis meníngea, no se observaron diferencias entre pacientes con y sin VIH/sida. Las secuelas cognoscitivas mostraron mejoría en el seguimiento con el adecuado manejo y control terapéutico de los pacientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Tuberculosis in Mexico remains an important cause of morbidity and mortality; in the last four years, 110,681 cases of pulmonary tuberculosis and 1,571 cases of tuberculous meningitis were reported.  Objective: To determine the neurocognitive sequelae, clinical presentation and neuroimaging alterations in patients with central nervous system tuberculosis.  Methods: A retrospective, analytical, cross-sectional study was carried out from 2010 to 2019. Patients with central nervous system tuberculosis, with and without HIV/AIDS coinfection, were included.  Results: During the study period, 104 cases with a definitive or probable central nervous system tuberculosis diagnosis were included; according to the Marais criteria, 38 % had HIV/AIDS coinfection, and 55 %, various comorbidities (p = 0.0001); 49 % had cognitive alterations, and 14 % died.  Conclusions: Although HIV/AIDS infection can contribute to cognitive decline in patients with tuberculous meningitis, no differences were observed between patients with and without HIV/AIDS. Cognitive sequelae showed improvement during follow-up with adequate management and therapeutic control of the patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Deterioro cognitivo]]></kwd>
<kwd lng="es"><![CDATA[Secuelas cognitivas]]></kwd>
<kwd lng="es"><![CDATA[Tuberculosis meníngea]]></kwd>
<kwd lng="es"><![CDATA[Sistema nervioso central]]></kwd>
<kwd lng="es"><![CDATA[VIH/sida]]></kwd>
<kwd lng="en"><![CDATA[Cognitive impairment]]></kwd>
<kwd lng="en"><![CDATA[Cognitive sequelae]]></kwd>
<kwd lng="en"><![CDATA[Tuberculous meningitis]]></kwd>
<kwd lng="en"><![CDATA[Central nervous system]]></kwd>
<kwd lng="en"><![CDATA[HIV/AIDS]]></kwd>
</kwd-group>
</article-meta>
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