<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2696-130X</journal-id>
<journal-title><![CDATA[Revista mexicana de angiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. angiol.]]></abbrev-journal-title>
<issn>2696-130X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Angiología, Cirugía Vascular y Endovascular A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2696-130X2025000200005</article-id>
<article-id pub-id-type="doi">10.24875/rma.23000040</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Lipedema: a revision and new lines of investigation in the comprehensive vascular field]]></article-title>
<article-title xml:lang="es"><![CDATA[Lipedema: una revisión y nuevas líneas de investigación en el campo vascular integral]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santillán-Aguayo]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro para el Tratamiento Integral de las Enfermedades Vasculares Centro para el Tratamiento Integral de las Enfermedades Vasculares ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>53</volume>
<numero>2</numero>
<fpage>72</fpage>
<lpage>80</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2696-130X2025000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2696-130X2025000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2696-130X2025000200005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Lipedema is a disease that involves multiple biomechanical changes and, therefore, vascular, musculoskeletal, skin, and nerve changes, requiring comprehensive and multidisciplinary treatment. This entity should be completely removed from the concepts applied by plastic surgery, as the action subsumes the concept to a cosmetic problem that requires or not cosmetic intervention, preventing the comprehensive benefit required by this group of patients. The most frequent musculoskeletal alterations include the pronation of the footstep due to the pronation position of the ankle, with or without the presence of a flat arch, hallux valgus, or indirect findings such as linear hyperkeratosis on the medial transition edge of the first toe, even medial rotation of the distal phalanx of the first toe. It is also accompanied by valgus in the knees, pelvic dysmetria, and spondyloarthropathy. Vascular alterations include venous disease and lymphedema, skin predisposition to dermatopathies as well as the appearance of spontaneous bruising or mild traumas, and nerve changes such as secondary neuropathies. Finally, it is essential to study the association of lipedema with nervous dysautonomia, since a large percentage of patients tend to have hypotension, the presence of orthostatic intolerance, thermoregulatory alterations, and even symptoms associated with vesicular dyskinesia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El lipedema es una enfermedad que involucra múltiples alteraciones biomecánicas y, por lo tanto, vasculares, musculoesqueléticas, cutáneas y nerviosas, que requiere de un tratamiento integral y multidisciplinario, que debe alejarse por completo de los conceptos aplicados por la cirugía plástica, puesto que la acción subsume el concepto a un problema estético que requiere o no de una intervención estética, impidiendo el beneficio integral que requiere este grupo de pacientes. Las alteraciones musculoesqueléticas más frecuentes incluyen la pronación de la pisada por la posición en pronación del tobillo, con o sin la presencia de un arco plano, hallux valgus o hallazgos indirectos como hiperqueratosis lineal en el borde de transición medial del primer ortejo, incluso rotación medial de la falange distal del primer ortejo, también se acompaña de valgo en rodillas, dismetría pélvica y espondiloartropatía. Las alteraciones vasculares incluyen enfermedad venosa y linfedema, predisposición a dermatopatías, así como aparición de equimosis espontáneas o traumas leves, y nerviosas, como las neuropatías secundarias. Por último, es esencial estudiar la asociación de lipedema con disautonomía nerviosa, puesto que un gran porcentaje de pacientes tiende a la hipotensión, a la presencia de intolerancia ortostática y alteraciones termorregulatorias, incluso síntomas asociados a discinescia vesicular.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Lipedema]]></kwd>
<kwd lng="en"><![CDATA[Lipoedema]]></kwd>
<kwd lng="en"><![CDATA[Venous disease]]></kwd>
<kwd lng="en"><![CDATA[Lymphatic disease]]></kwd>
<kwd lng="es"><![CDATA[Lipedema]]></kwd>
<kwd lng="es"><![CDATA[Lipoedema]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad venosa]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad linfática]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Herbst]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
<name>
<surname><![CDATA[Kahn]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Iker]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Ehrlich]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Wright]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[McHutchison]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Standard of care for lipedema in the United States]]></article-title>
<source><![CDATA[Phlebology]]></source>
<year>2021</year>
<volume>36</volume>
<page-range>779-96</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wold]]></surname>
<given-names><![CDATA[LE]]></given-names>
</name>
<name>
<surname><![CDATA[Hines]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Allen]]></surname>
<given-names><![CDATA[EV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipedema of the legs;a syndrome characterized by fat legs and edema]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year></year>
<volume>34</volume>
<page-range>1243-50</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Child]]></surname>
<given-names><![CDATA[AH]]></given-names>
</name>
<name>
<surname><![CDATA[Gordon]]></surname>
<given-names><![CDATA[KD]]></given-names>
</name>
<name>
<surname><![CDATA[Sharpe]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Brice]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Ostergaard]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Jeffery]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipedema:an inherited condition]]></article-title>
<source><![CDATA[Am J Med Genet Part A]]></source>
<year>2010</year>
<volume>152</volume>
<page-range>970-6</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[van la Parra]]></surname>
<given-names><![CDATA[RF]]></given-names>
</name>
<name>
<surname><![CDATA[Deconinck]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Krug]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diagnostic imaging in lipedema:a systematic review]]></article-title>
<source><![CDATA[Obes Rev]]></source>
<year>2024</year>
<volume>25</volume>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[von Atzigen]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Burger]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Grünherz]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Barbon]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Felmerer]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Giovanoli]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A comparative analysis to dissect the histological and molecular differences among lipedema, lipohypertrophy and secondary lymphedema]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2023</year>
<volume>24</volume>
<page-range>7591</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Felmerer]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Stylianaki]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hägerling]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ströbel]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Hollmén]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Adipose tissue hypertrophy, an aberrant biochemical profile and distinct gene expression in lipedema]]></article-title>
<source><![CDATA[J Surg Res]]></source>
<year>2020</year>
<volume>253</volume>
<page-range>294-303</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Czerwi&#324;ska]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ostrowska]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Hansdorfer-Korzon]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipoedema as a social problem. A scoping review]]></article-title>
<source><![CDATA[Int J Environ Res Public Health]]></source>
<year>2021</year>
<volume>18</volume>
<page-range>10223</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Halk]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
<name>
<surname><![CDATA[Damstra]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[First Dutch guidelines on lipedema using the international classification of functioning, disability and health]]></article-title>
<source><![CDATA[Phlebology]]></source>
<year>2017</year>
<volume>32</volume>
<page-range>152-9</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Forner-Cordero]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Szolnoky]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Forner-Cordero]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kemény]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipedema:an overview of its clinical manifestations, diagnosis and treatment of the disproportional fatty deposition syndrome - systematic review]]></article-title>
<source><![CDATA[Clin Obes]]></source>
<year>2012</year>
<volume>2</volume>
<page-range>86-95</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Santillán-Aguayo]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Rivera-Sánchez]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Carbajal-Robles]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Piña-Avilés]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Duarte-Acuña]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Ramírez-Berúmen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chronic venous insufficiency symptoms and its potential causes:are we doing it right ?]]></article-title>
<source><![CDATA[Rev Mex Angiol]]></source>
<year>2021</year>
<volume>49</volume>
<page-range>1-10</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Torre]]></surname>
<given-names><![CDATA[YS]]></given-names>
</name>
<name>
<surname><![CDATA[Wadeea]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Rosas]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Herbst]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipedema:friend and foe]]></article-title>
<source><![CDATA[Horm Mol Biol Clin Investig]]></source>
<year>2018</year>
<volume>33</volume>
<page-range>1-15</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
