<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2524-177X</journal-id>
<journal-title><![CDATA[Revista médica del Hospital General de México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. med. Hosp. Gen. Méx.]]></abbrev-journal-title>
<issn>2524-177X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Médica del Hospital General de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2524-177X2020000300120</article-id>
<article-id pub-id-type="doi">10.24875/hgmx.20000086</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Accuracy of the tuberculin skin test for diagnosis of latent tuberculosis in population with high coverage of Bacillus Calmette&#8211;Guérin vaccination]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Báez-Saldaña]]></surname>
<given-names><![CDATA[Renata]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-García]]></surname>
<given-names><![CDATA[Lourdes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreyra-Reryes]]></surname>
<given-names><![CDATA[Leticia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz-Hervert]]></surname>
<given-names><![CDATA[Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mongua-Rodríguez]]></surname>
<given-names><![CDATA[Norma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Delgado-Sánchez]]></surname>
<given-names><![CDATA[Guadalupe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira-Guerrero]]></surname>
<given-names><![CDATA[Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rendón]]></surname>
<given-names><![CDATA[Adrián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Enfermedades Respiratorias Clinical Service of Oncological Pneumology ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México School of Medicine Subdivision of Medical Specializations]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Salud Pública Infectious Disease Research Center ]]></institution>
<addr-line><![CDATA[Cuernavaca Morelos]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Universitario de Monterrey Prevention and Treatment of Respiratory Infections ]]></institution>
<addr-line><![CDATA[Monterrey Nuevo Leon]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>83</volume>
<numero>3</numero>
<fpage>120</fpage>
<lpage>126</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2524-177X2020000300120&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2524-177X2020000300120&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2524-177X2020000300120&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ Introduction: The Mantoux tuberculin skin test (TST) for the diagnosis of latent tuberculosis infection (LTBI) has a variable performance and limited usefulness in Bacillus Calmette&#8211;Guérin (BCG)-vaccinated populations.  Objective: The objective of the study was to evaluate the performance of the TST for the diagnosis of LTBI in household contacts of patients with active pulmonary tuberculosis (PTB).  Materials and methods: The TST was administered to 113 cases with PTB and 194 household contacts. The gold standard was the bacteriological confirmation in patients. The household contacts were classified as true positives according to the selected cutoff point. Those with purified protein derivative reactivity less than the cutoff point but different from zero were classified as false positives. The area under the curve was measured and the best cutoff point was determined. Sensitivity, specificity, positive and negative predictive values (PV), and positive and negative likelihood ratios (LR) were measured with 2 × 2 contingency tables.  Results: The best cutoff point was at 10 mm of induration, with an area under the curve of 0.93, sensitivity 85%, specificity 88%, positive PV 94%, negative PV 71%, positive LR 6.9, and negative LR 0.17. There was no association between reactivity to TST and BCG vaccination, OR (95% confidence interval CI) 1.14 (0.65-2.10), p = 0.644.  Conclusions: The TST showed a very good performance, as it lead to an important change from pre-test to post-test probability.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Latent tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[Tuberculin skin test]]></kwd>
<kwd lng="en"><![CDATA[Specificity]]></kwd>
<kwd lng="en"><![CDATA[Bacillus Calmette&#8211;Guérin vaccination]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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