<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902023000400297</article-id>
<article-id pub-id-type="doi">10.29262/ram.v70i4.1340</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aplicación de biológicos en pacientes con alergia alimentaria]]></article-title>
<article-title xml:lang="en"><![CDATA[Application of biologicals in patients with food allergies]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Agar Muñoz]]></surname>
<given-names><![CDATA[Ana María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Galván Calle]]></surname>
<given-names><![CDATA[César Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Clínica Indisa  ]]></institution>
<addr-line><![CDATA[Santiago de Chile ]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Clínica Internacional Lima-Peru  ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Perú</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>70</volume>
<numero>4</numero>
<fpage>297</fpage>
<lpage>299</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902023000400297&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902023000400297&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902023000400297&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen A pesar de los avances prometedores en la inmunoterapia oral para alergias alimentarias, su implementación médica enfrenta limitaciones. Se investigan opciones no específicas basadas en la inhibición de la vía inflamatoria tipo 2, incluyendo anticuerpos monoclonales. El TNX-901 y omalizumab han demostrado aumentar los umbrales de reacción, reduciendo eventos adversos en pacientes con alergia al cacahuate. El dupilumab, que bloquea el receptor alfa de IL-4, muestra resultados positivos en alergias alimentarias, así como en la esofagitis eosinofílica. Anticuerpos contra alarminas y anti-IL-5, como etokimab y mepolizumab, han demostrado eficacia en estudios preclínicos y ensayos clínicos. Aunque se necesitan más estudios para establecer su uso clínico práctico y determinar la idoneidad para distintos tipos de alergias alimentarias, estos anticuerpos monoclonales presentan un horizonte prometedor para el tratamiento de dichas condiciones.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Despite promising advancements in oral immunotherapy for food allergies, medical implementation faces limitations. Non-specific treatment options based on inhibiting the type 2 inflammatory pathway, including monoclonal antibodies, are under investigation. TNX-901 and omalizumab have demonstrated increased reaction thresholds, reducing adverse events in peanut-allergic patients. Dupilumab, blocking the IL-4 receptor, shows positive results in both food allergies and eosinophilic esophagitis. Antibodies against alarmins and anti-IL-5, such as etokimab and mepolizumab, have proven efficacy in preclinical studies and clinical trials. While further studies are needed to establish their practical clinical use and determine suitability for different types of food allergies, these monoclonal antibodies present a promising horizon for the treatment of such conditions.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Alergia alimentaria]]></kwd>
<kwd lng="es"><![CDATA[Inmunoterapia oral]]></kwd>
<kwd lng="es"><![CDATA[Anticuerpos monoclonales]]></kwd>
<kwd lng="es"><![CDATA[TNX-901]]></kwd>
<kwd lng="es"><![CDATA[Omalizumab]]></kwd>
<kwd lng="es"><![CDATA[Dupilumab]]></kwd>
<kwd lng="es"><![CDATA[Etokimab]]></kwd>
<kwd lng="es"><![CDATA[Mepolizumab]]></kwd>
<kwd lng="en"><![CDATA[Food allergy]]></kwd>
<kwd lng="en"><![CDATA[Oral immunotherapy]]></kwd>
<kwd lng="en"><![CDATA[Monoclonal antibodies]]></kwd>
<kwd lng="en"><![CDATA[TNX-901]]></kwd>
<kwd lng="en"><![CDATA[Omalizumab]]></kwd>
<kwd lng="en"><![CDATA[Dupilumab]]></kwd>
<kwd lng="en"><![CDATA[Etokimab]]></kwd>
<kwd lng="en"><![CDATA[Mepolizumab]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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