<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902020000300279</article-id>
<article-id pub-id-type="doi">10.29262/ram.v67i3.831</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Fases para determinar la utilidad clínica de las pruebas diagnósticas]]></article-title>
<article-title xml:lang="en"><![CDATA[Phases to determine the clinical utility of diagnostic tests]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rendón-Macías]]></surname>
<given-names><![CDATA[Mario Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villasís-Keever]]></surname>
<given-names><![CDATA[Miguel Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Panamericana Escuela de Medicina ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Centro Médico Nacional Siglo XXI Unidad de Investigación en Análisis y Síntesis de la Evidencia]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>67</volume>
<numero>3</numero>
<fpage>279</fpage>
<lpage>285</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902020000300279&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902020000300279&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902020000300279&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Generalmente, las pruebas de diagnóstico son las herramientas necesarias para determinar la presencia o no de enfermedad, pero también pueden ser útiles para la exclusión de otras entidades diferenciales, evaluar la gravedad, establecer tratamientos específicos y estimar posibles resultados pronóstico. Para determinar cuánto puede contribuir una nueva prueba de diagnóstico en el ámbito clínico, se requieren estudios con diseños de investigación y poblaciones diferentes. Dado que puede resultar complejo entender el desarrollo de una prueba diagnóstica a partir de sus fases iniciales, en este artículo se sintetizan y se proporcionan ejemplos de las cuatro fases que se han propuesto para definir este proceso. Las metas de estas etapas son las siguientes: fase I, establecimiento de valores de referencia; fase II, análisis de la validez de la prueba; fase III, impacto de su incorporación en el plan diagnóstico; fase IV, evaluación a largo plazo de la incorporación de las prueba diagnóstica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract In general, diagnostic tests are the necessary tools to determine the presence or absence of illness, but they can be useful also for excluding other differential conditions, assessing severity, establishing specific treatments, and estimating possible prognosis results. In order to determine how much a new diagnostic test can contribute in the clinical setting, studies with different research designs and populations are required. Since it might be complex to understand the development process of a diagnostic test based on its initial stages, this article synthesizes and gives examples of the four phases that have been proposed to define this process. The goals of these four phases are: phase I, establishing reference values; phase II, analyzing the validity of the test; phase III, the impact of its incorporation in diagnostic-therapeutic plans; and phase IV, a long-term assessment after incorporating the diagnostic test.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Pruebas diagnósticas]]></kwd>
<kwd lng="es"><![CDATA[Fases de desarrollo]]></kwd>
<kwd lng="es"><![CDATA[Validación]]></kwd>
<kwd lng="en"><![CDATA[Diagnostic tests]]></kwd>
<kwd lng="en"><![CDATA[Development phases]]></kwd>
<kwd lng="en"><![CDATA[Validation]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bolboac&#259;]]></surname>
<given-names><![CDATA[SD.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Medical diagnostic tests: A review of test anatomy, phases, and statistical treatment of data]]></article-title>
<source><![CDATA[Comput Math Methods Med.]]></source>
<year>2019</year>
<volume>2019</volume>
<page-range>1891569</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sackett]]></surname>
<given-names><![CDATA[DL]]></given-names>
</name>
<name>
<surname><![CDATA[Haynes]]></surname>
<given-names><![CDATA[RB.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The architecture of diagnostic research]]></article-title>
<source><![CDATA[BMJ]]></source>
<year>2002</year>
<volume>324</volume>
<numero>7336</numero>
<issue>7336</issue>
<page-range>539-41</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Colli]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fraquelli]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Casazza]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Conte]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Nikolova]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Duca]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The architecture of diagnostic research: from bench to bedside--research guidelines using liver stiffness as an example]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>2014</year>
<volume>60</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>408-18</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zurita-Cruz]]></surname>
<given-names><![CDATA[JN]]></given-names>
</name>
<name>
<surname><![CDATA[Barbosa-Cortés]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Villasís-Keever]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[De la investigación a la práctica: fases clínicas para el desarrollo de fármacos]]></article-title>
<source><![CDATA[Rev Alerg Mex.]]></source>
<year>2019</year>
<volume>66</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>246-53</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gluud]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gluud]]></surname>
<given-names><![CDATA[LL.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evidence based diagnostics]]></article-title>
<source><![CDATA[BMJ.]]></source>
<year>2005</year>
<volume>330</volume>
<numero>7493</numero>
<issue>7493</issue>
<page-range>724-6</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rendón-Macías]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Villasís-Keever]]></surname>
<given-names><![CDATA[MÁ]]></given-names>
</name>
<name>
<surname><![CDATA[Miranda-Novales]]></surname>
<given-names><![CDATA[MG.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estadística descriptiva]]></article-title>
<source><![CDATA[Rev Alerg Mex.]]></source>
<year>2016</year>
<volume>63</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>397-407</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Buchvald]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Baraldi]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Carraro]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gaston]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Jongste]]></surname>
<given-names><![CDATA[J de]]></given-names>
</name>
<name>
<surname><![CDATA[Pijnenburg]]></surname>
<given-names><![CDATA[MWH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years]]></article-title>
<source><![CDATA[J Allergy Clin Immunol.]]></source>
<year>2005</year>
<volume>115</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1130-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rendón-Macías]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Valenzuela]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Villasís-Keever]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sesgos en los estudios de pruebas de diagnóstico: implicación en la estimación de la sensibilidad y especificidad]]></article-title>
<source><![CDATA[Rev Alerg Mex.]]></source>
<year>2020</year>
<volume>67</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>165-73</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Malmberg]]></surname>
<given-names><![CDATA[LP]]></given-names>
</name>
<name>
<surname><![CDATA[Pelkonen]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[Haahtela]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Turpeinen]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma]]></article-title>
<source><![CDATA[Thorax]]></source>
<year>2003</year>
<volume>58</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>494-9</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Eom]]></surname>
<given-names><![CDATA[SY]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[JK]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[YJ]]></given-names>
</name>
<name>
<surname><![CDATA[Hahn]]></surname>
<given-names><![CDATA[YS.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Combining spirometry and fractional exhaled nitric oxide improves diagnostic accuracy for childhood asthma]]></article-title>
<source><![CDATA[Clin Respir J.]]></source>
<year>2020</year>
<volume>14</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>21-8</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boer]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Honkoop]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Loijmans]]></surname>
<given-names><![CDATA[RJB]]></given-names>
</name>
<name>
<surname><![CDATA[Snoeck-Stroband]]></surname>
<given-names><![CDATA[JB]]></given-names>
</name>
<name>
<surname><![CDATA[Assendelft]]></surname>
<given-names><![CDATA[WJJ]]></given-names>
</name>
<name>
<surname><![CDATA[Schermer]]></surname>
<given-names><![CDATA[TRJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Personalised exhaled nitric oxygen fraction (FENO)-driven asthma management in primary care: a subgroup analysis of the ACCURATE trial]]></article-title>
<source><![CDATA[ERJ Open Res.]]></source>
<year>2020</year>
<volume>6</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>00351-2019</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Larenas-Linnemann]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Gochicoa-Rangel]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Macías-Weinmann]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Soto-Ramos]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Luna-Pech]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Elizondo-Ríos]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Consenso mexicano en relación con la fracción exhalada de óxido nítrico (FeNO) en asma 2020]]></article-title>
<source><![CDATA[Rev Alerg Mex.]]></source>
<year>2020</year>
<volume>67</volume>
<numero>^s2</numero>
<issue>^s2</issue>
<supplement>2</supplement>
<page-range>S1-S25</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
