<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092024000400316</article-id>
<article-id pub-id-type="doi">10.35366/118225</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Farmacovigilancia en la Unidad de Cuidados Intensivos respecto a un reporte de caso de metahemoglobinemia]]></article-title>
<article-title xml:lang="en"><![CDATA[Pharmacovigilance at the Intensive Care Unit regard a methemoglobin case report]]></article-title>
<article-title xml:lang="pt"><![CDATA[Farmacovigilância na Unidade de Terapia Intensiva em relação a um relato de caso de metahemoglobinemia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Giraldo Sánchez]]></surname>
<given-names><![CDATA[Javier Mauricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Tolima UCI Honda  ]]></institution>
<addr-line><![CDATA[Honda Tolima]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>38</volume>
<numero>4</numero>
<fpage>316</fpage>
<lpage>319</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092024000400316&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092024000400316&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092024000400316&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La polimedicación al interior de las unidades de cuidados intensivos en escenarios clínicos específicos y grupos poblacionales de riesgo se constituye como un factor detonante exponencialmente alto para generar trastornos de la porción hemo de la hemoglobina. Los diferentes paquetes instruccionales de atención que nuestros pacientes reciben no están alineados ni articulados con el factor etario más allá del ajuste frente a diversas disfunciones orgánicas en términos de dosificación. Adicionalmente, las bondades de la cooximetría no están disponibles de manera regular al lado de la cama de pacientes críticamente enfermos, lo que implica un subregistro muy grave que puede aumentar la morbilidad y mortalidad de nuestros pacientes. Presentamos el caso clínico de una paciente de 80 años de edad con infección de vías urinarias por germen con resistencia extendida quien, en ausencia de bajo gasto o sufrimiento mitocondrial, debutó con acidemia metabólica persistente sin causa clara.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Polypharmacy within intensive care units in specific clinical settings and population groups at risk is an exponentially high triggering factor to generate disorders of the heme portion of hemoglobin. The different instructional packages of care that our patients receive are not aligned or articulated with the age factor beyond the adjustment against various organ dysfunctions in terms of dosage. Additionally, the benefits of Co-oximetry are not available on a regular basis at the bedside of critically ill patients, which implies a very serious underreporting that can increase the morbidity and mortality of our patients. We present the clinical case of an 80-year-old female patient with urinary tract infection caused by a germ with extended resistance who in the absence of mitochondrial suffering or low output cardiac presented with persistent metabolic acidemia without a clear cause.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: A polifarmácia em unidades de terapia intensiva em cenários clínicos específicos e grupos populacionais de risco constitui fator desencadeante exponencialmente elevado para gerar distúrbios da porção HEME da hemoglobina. Os diferentes pacotes instrucionais de cuidados que nossos pacientes recebem não estão alinhados ou articulados com o fator idade, além do ajuste para várias disfunções orgânicas em termos de dosagem. Além disso, os benefícios da Co-Oximetria não estão regularmente disponíveis à beira do leito de pacientes gravemente enfermos, o que implica uma subnotificação muito grave que pode aumentar a morbimortalidade dos nossos pacientes. Apresentamos o caso clínico de um paciente de 80 anos com infecção do trato urinário por germe de resistência generalizada que, na ausência de baixo débito ou sofrimento mitocondrial, apresentou acidemia metabólica persistente sem causa clara.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[oxidación]]></kwd>
<kwd lng="es"><![CDATA[ion ferroso]]></kwd>
<kwd lng="es"><![CDATA[ion férrico]]></kwd>
<kwd lng="es"><![CDATA[metahemoglobina]]></kwd>
<kwd lng="es"><![CDATA[farmacovigilancia]]></kwd>
<kwd lng="en"><![CDATA[oxidation]]></kwd>
<kwd lng="en"><![CDATA[ferrous ion]]></kwd>
<kwd lng="en"><![CDATA[ferric ion]]></kwd>
<kwd lng="en"><![CDATA[methemoglobine]]></kwd>
<kwd lng="en"><![CDATA[pharmacovigilance]]></kwd>
<kwd lng="pt"><![CDATA[oxidação]]></kwd>
<kwd lng="pt"><![CDATA[íon ferroso]]></kwd>
<kwd lng="pt"><![CDATA[íon férrico]]></kwd>
<kwd lng="pt"><![CDATA[metemoglobina]]></kwd>
<kwd lng="pt"><![CDATA[farmacovigilância]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vincent]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Carlet]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Opal]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Veno-arterial PCO2 gradient]]></article-title>
<source><![CDATA[The sepsis text]]></source>
<year>2002</year>
<page-range>339-40</page-range><publisher-loc><![CDATA[Boston, Massachusetts ]]></publisher-loc>
<publisher-name><![CDATA[Kluwer Academic Publishers]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Teboul]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Monnet]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical use of venoarterial PCO2 difference in septic shock]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Vincent]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<source><![CDATA[Yearbook of intensive care and emergency medicine]]></source>
<year>2003</year>
<page-range>574-82</page-range><publisher-loc><![CDATA[Berlin Heidelberg New York ]]></publisher-loc>
<publisher-name><![CDATA[Springer-Verlag]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nordmann]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Poirel]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Emerging carbapenemases in Gramnegative aerobes]]></article-title>
<source><![CDATA[Clin Microbiol Infect]]></source>
<year>2002</year>
<volume>8</volume>
<page-range>321-38</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chanques]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Ely]]></surname>
<given-names><![CDATA[EW]]></given-names>
</name>
<name>
<surname><![CDATA[Garnier]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Perrigault]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Eloi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Carr]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The 2014 updated version of the Confusion Assessment Method for the Intensive Care Unit compared to the 5th version of the Diagnostic and Statistical Manual of Mental Disorders and other current methods used by intensivists]]></article-title>
<source><![CDATA[Ann Intensive Care]]></source>
<year>2018</year>
<volume>8</volume>
<page-range>33</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ely]]></surname>
<given-names><![CDATA[EW]]></given-names>
</name>
<name>
<surname><![CDATA[Truman]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Shintani]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Thomason]]></surname>
<given-names><![CDATA[JWW]]></given-names>
</name>
<name>
<surname><![CDATA[Wheeler]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Gordon]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Monitoring sedation status over time in ICU patients: the reliability and validity of the Richmond Agitation Sedation Scale (RASS)]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>2003</year>
<volume>289</volume>
<page-range>2983-91</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van den Boogaard]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pickkers]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Slooter]]></surname>
<given-names><![CDATA[AJC]]></given-names>
</name>
<name>
<surname><![CDATA[Kuiper]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Spronk]]></surname>
<given-names><![CDATA[PE]]></given-names>
</name>
<name>
<surname><![CDATA[van der Voort]]></surname>
<given-names><![CDATA[PHJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study]]></article-title>
<source><![CDATA[BMJ]]></source>
<year>2012</year>
<volume>344</volume>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kimura]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Shabsigh]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Morimatsu]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Traditional approach versus Stewart approach for acid-base disorders: Inconsistent evidence]]></article-title>
<source><![CDATA[SAGE Open Med]]></source>
<year>2018</year>
<volume>6</volume>
<page-range>2050-3121</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schiraldi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Guiotto]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Base excess, strong ion difference, and expected compensations: as simple as it is]]></article-title>
<source><![CDATA[Eur J Emerg Med]]></source>
<year>2014</year>
<volume>21</volume>
<page-range>403-8</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rehman]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Shehadeh]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Khirfan]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Jones]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Severe acute haemolytic anaemia associated with severe methaemoglobinaemia in a G6PD-deficient man]]></article-title>
<source><![CDATA[BMJ Case Rep]]></source>
<year>2018</year>
<volume>2018</volume>
<page-range>bcr2017223369</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Xiong]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Xiong]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Ren]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Exhaustive exercise-induced oxidative stress alteration of erythrocyte oxygen release capacity]]></article-title>
<source><![CDATA[Can J Physiol Pharmacol]]></source>
<year>2018</year>
<volume>96</volume>
<page-range>953-62</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huet]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Dupic]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Batteux]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Matar]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Conti]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Chereau]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Postresuscitation syndrome: potential role of hydroxyl radical-induced endothelial cell damage]]></article-title>
<source><![CDATA[Critical Care Medicine]]></source>
<year>2011</year>
<volume>39</volume>
<page-range>1712-20</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Choi]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[HS]]></given-names>
</name>
<name>
<surname><![CDATA[Choi]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Yi]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Correlation between cognitive ability measured by response time of 1-back task and changes of SpO2 by suppling three different levels of oxygen in the elderly]]></article-title>
<source><![CDATA[Geriatr Gerontol Int]]></source>
<year>2013</year>
<volume>13</volume>
<page-range>384-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="">
<source><![CDATA[World Health Organization Patient Safety: making health care safer Number of pages: 20]]></source>
<year>2017</year>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rolley]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bandeshe]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Boots]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8221;Safe&#8221; methaemoglobin concentrations are a mortality risk factor in patients receiving inhaled nitric oxide]]></article-title>
<source><![CDATA[Anaesth Intensive Care]]></source>
<year>2011</year>
<volume>39</volume>
<page-range>919-25</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thomas]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Valentine]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Utility of routine methemoglobin laboratory assays in critically ill pediatric subjects receiving inhaled nitric oxide]]></article-title>
<source><![CDATA[J Crit Care]]></source>
<year>2018</year>
<volume>48</volume>
<page-range>63-5</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lei]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Berra]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Rezoagli]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Dong]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nitric oxide decreases acute kidney injury and stage 3 chronic kidney disease after cardiac surgery]]></article-title>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2018</year>
<volume>198</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1279-87</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Baines]]></surname>
<given-names><![CDATA[SD]]></given-names>
</name>
<name>
<surname><![CDATA[Freeman]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wilcox]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model]]></article-title>
<source><![CDATA[J Antimicrob Chemother]]></source>
<year>2005</year>
<volume>55</volume>
<page-range>974-82</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[YC]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[QX]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[XE]]></given-names>
</name>
<name>
<surname><![CDATA[Gao]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Bai]]></surname>
<given-names><![CDATA[XJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Caspase-1-dependent pyroptosis of peripheral blood mononuclear cells predicts the development of sepsis in severe trauma patients: a prospective observational study]]></article-title>
<source><![CDATA[Medicine (Baltimore)]]></source>
<year>2018</year>
<volume>97</volume>
<numero>8</numero>
<issue>8</issue>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Currell]]></surname>
<given-names><![CDATA[DL]]></given-names>
</name>
<name>
<surname><![CDATA[Levin]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide]]></article-title>
<source><![CDATA[Eur J Biochem]]></source>
<year>2002</year>
<volume>269</volume>
<page-range>4635-40</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saiko]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Zheng]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Betlen]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Douplik]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Visualization of methemoglobin distribution in tissues: phantom validation]]></article-title>
<source><![CDATA[Adv Exp Med Biol]]></source>
<year>2018</year>
<volume>1072</volume>
<page-range>387-90</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Yates]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Bielecki]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Olczak]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Smalley]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Potential role for Streptococcus gordonii-derived hydrogen peroxide in heme acquisition by Porphyromonas gingivalis]]></article-title>
<source><![CDATA[Mol Oral Microbiol]]></source>
<year>2018</year>
<volume>33</volume>
<page-range>322-35</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Santa María-Salamanca]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Londoño-Soto]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<source><![CDATA[Consejo Unidad Sectorial de Normalización en Salud 14 de julio de 2011. Ministerio de la Protección Social ISBN: 978-958-8717-33-3 Manual de acreditación en salud, ambulatorio y hospitalario. Colombia]]></source>
<year>2011</year>
<page-range>30-45</page-range><publisher-loc><![CDATA[Colombia ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Queirós]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Salvador]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ventura]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Methemoglobinemia after paracetamol ingestion: a case report]]></article-title>
<source><![CDATA[Acta Med Port]]></source>
<year>2017</year>
<volume>30</volume>
<page-range>753-6</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[TMS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dual effects include antioxidant and prooxidation of ascorbic acid on the redox properties of bovine hemoglobin]]></article-title>
<source><![CDATA[Artif Cells Nanomed Biotechnol]]></source>
<year>2018</year>
<volume>2</volume>
<page-range>1-10</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Benz]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Ebert]]></surname>
<given-names><![CDATA[BL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hemoglobin variants associated with hemolytic anemia, altered oxygen affinity and methaemoglobinemias]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Hoffman]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Benz]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Silberstein]]></surname>
<given-names><![CDATA[LE]]></given-names>
</name>
</person-group>
<source><![CDATA[Hematology: Basic Principles and Practice]]></source>
<year>2018</year>
<edition>7th</edition>
<publisher-loc><![CDATA[Philadelphia, PA ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Xiong Y1, Xiong]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of glutathione synthesis induced by exhaustive running exercise via the decreased influx rate of L-Cysteine in rat erythrocytes]]></article-title>
<source><![CDATA[Cell Physiol Biochem]]></source>
<year>2016</year>
<volume>40</volume>
<page-range>1410-21</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yamada]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Sakai]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hidden antioxidative functions of reduced nicotinamide adenine dinucleotide coexisting with hemoglobin]]></article-title>
<source><![CDATA[ACS Chem Biol]]></source>
<year>2017</year>
<volume>12</volume>
<page-range>1820-9</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yamaji]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Soeda]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Shibata]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Morikawa]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Suzuki]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Yoshida]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A new mutation of congenital methemoglobinemia exacerbated after methylene blue treatment]]></article-title>
<source><![CDATA[Acute Med Surg]]></source>
<year>2018</year>
<volume>5</volume>
<page-range>199-201</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silkstone]]></surname>
<given-names><![CDATA[GGA]]></given-names>
</name>
<name>
<surname><![CDATA[Simons]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rajagopal]]></surname>
<given-names><![CDATA[BS]]></given-names>
</name>
<name>
<surname><![CDATA[Shaik]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Reeder]]></surname>
<given-names><![CDATA[BJ]]></given-names>
</name>
<name>
<surname><![CDATA[Cooper]]></surname>
<given-names><![CDATA[CE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Novel redox active tyrosine mutations enhance the regeneration of functional oxyhemoglobin from methemoglobin: implications for design of blood substitutes]]></article-title>
<source><![CDATA[Adv Exp Med Biol]]></source>
<year>2018</year>
<volume>1072</volume>
<page-range>221-5</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[You]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Influenceof polydopamine-mediated surface modification on oxygenrelease capacity of haemoglobin-based oxygen carriers]]></article-title>
<source><![CDATA[Artif Cells Nanomed Biotechnol]]></source>
<year>2018</year>
<volume>10</volume>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cho]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[SW]]></given-names>
</name>
<name>
<surname><![CDATA[Han]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[HB]]></given-names>
</name>
<name>
<surname><![CDATA[Yeom]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A case of methemoglobinemia successfully treated with hyperbaric oxygenation monotherapy]]></article-title>
<source><![CDATA[J Emerg Med]]></source>
<year>2017</year>
<volume>53</volume>
<page-range>685-7</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
