<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092023000700559</article-id>
<article-id pub-id-type="doi">10.35366/114857</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Variabilidad de la frecuencia cardiaca como predictor temprano de mortalidad en pacientes con sepsis en la Unidad de Cuidados Intensivos]]></article-title>
<article-title xml:lang="en"><![CDATA[Heart rate variability as an early predictor of mortality in patients with sepsis in the Intensive Care Unit]]></article-title>
<article-title xml:lang="pt"><![CDATA[Variabilidade da frequência cardíaca como preditor precoce de mortalidade em pacientes com sepse na Unidade de Terapia Intensiva]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ángeles Carreón]]></surname>
<given-names><![CDATA[Diana Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Romero]]></surname>
<given-names><![CDATA[Karen Saraí]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez Barba]]></surname>
<given-names><![CDATA[Christian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Balderas Peña]]></surname>
<given-names><![CDATA[Luz María Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Médico Nacional de Occidente Hospital de Especialidades ]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>37</volume>
<numero>7</numero>
<fpage>559</fpage>
<lpage>565</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092023000700559&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092023000700559&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092023000700559&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  el índice LF/HF se ha relacionado con incremento en la severidad de la enfermedad y mortalidad en pacientes con sepsis. La variabilidad de la frecuencia cardiaca podría identificar de manera temprana al paciente con riesgo de deterioro.  Material y métodos:  estudio observacional de casos y controles con cálculo del riesgo de mortalidad. Se estableció el punto de corte de la variabilidad como predictor de mortalidad.  Resultados:  determinamos la relación LF/HF utilizando un punto de corte de 1.7 como estimador de riesgo de mortalidad con un OR de 32.3 (IC95% = 1.1 a 914; p = 0.042). Se estableció con una curva COR un punto de corte de 1.08, sensibilidad de 100% y especificidad de 68%. El análisis de la variabilidad con puntos de corte entre 1.08 y 1.4, valores mayores apuntan a un OR de 0.43 (IC95% = 0.26 a 0.7; p &lt; 0.001) y OR de 0.45 (IC95% = 0.29 a 0.72; p &lt; 0.001).  Conclusión:  existe una asociación entre la pérdida de la variabilidad de la frecuencia cardiaca como factor predictor de mortalidad en sepsis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  the LF/HF index has been related to increased severity of illness and the mortality rate of patients with sepsis. The heart rate variability can identify early the risk of adverse outcomes and death in septic patients.  Material and methods:  a case-control study with OR estimation for mortality and establishing a cutoff in the heart rate variability such as a mortality predictor.  Results:  we determined the LF/HF index with a cutoff of 1.7, considering in the literature to predict mortality with OR 32.3 (95% CI = 1.1 to 914; p = 0.042). Through a ROC analysis, we identified two cutoffs in our patient&#8217;s group, one in 1.08 and the other in 1.4, both with a sensitivity of 100% and specificity of around 70%. The risk analysis showed that values over 1.08 and 1.4 were risk reduction estimators with OR 0.43 (95% CI = 0.26 to 0.7; p &lt; 0.001) and 0.45 (95% CI = 0.3 to 0.72; p &lt; 0.001).  Conclusion:  there is an association between the loss of heart rate variability and the mortality risk in patients with sepsis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  a relação LF/HF tem sido associada ao aumento da gravidade da doença e da mortalidade em pacientes com sepse. A variabilidade da frequência cardíaca pode identificar precocemente pacientes em risco de deterioração.  Material e métodos:  estudo observacional caso-controle com cálculo de risco de mortalidade. O ponto de corte de variabilidade foi estabelecido como preditor de mortalidade.  Resultados:  determinamos a relação LF/HF utilizando um ponto de corte de 1.7 como estimador de risco de mortalidade com OR de 32.3 (IC95% = 1.1 a 914; p = 0.042). Estabeleceu-se com uma curva ROC um ponto de corte de 1.08, sensibilidade de 100% e especificidade de 68%. Na análise de variabilidade com pontos de corte entre 1.08 e 1.4, valores maiores apontam para OR de 0.43 (IC95% = 0.26 a 0.7; p &lt; 0.001) e OR de 0.45 (IC95% = 0.29 a 0.72; p &lt; 0.001).  Conclusão:  existe associação entre a perda da variabilidade da frequência cardíaca como preditor de mortalidade na sepse.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[variabilidad de frecuencia cardiaca]]></kwd>
<kwd lng="es"><![CDATA[índice LF/HF]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="es"><![CDATA[paciente crítico]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[heart rate variability]]></kwd>
<kwd lng="en"><![CDATA[LF/HF index]]></kwd>
<kwd lng="en"><![CDATA[mortality rate]]></kwd>
<kwd lng="en"><![CDATA[critically ill patient]]></kwd>
<kwd lng="pt"><![CDATA[sepse]]></kwd>
<kwd lng="pt"><![CDATA[variabilidade da frequência cardíaca]]></kwd>
<kwd lng="pt"><![CDATA[índice LF/HF]]></kwd>
<kwd lng="pt"><![CDATA[mortalidade]]></kwd>
<kwd lng="pt"><![CDATA[paciente em estado crítico]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gyawali]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Ramakrishna]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Dhamoon]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis: the evolution in definition, pathophysiology, and management]]></article-title>
<source><![CDATA[SAGE Open Med]]></source>
<year>2019</year>
<volume>7</volume>
<page-range>2050312119835043</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<source><![CDATA[Global report on the epidemiology and burden of sepsis: current evidence, identifying gaps and future directions]]></source>
<year>2020</year>
<publisher-loc><![CDATA[Geneva ]]></publisher-loc>
<publisher-name><![CDATA[World Health Organization]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Neira-Sánchez]]></surname>
<given-names><![CDATA[ER]]></given-names>
</name>
<name>
<surname><![CDATA[Málaga]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis-3 y las nuevas definiciones, ¿es tiempo de abandonar SIRS?]]></article-title>
<source><![CDATA[Acta Med Peru]]></source>
<year>2016</year>
<volume>33</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>217-22</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cortés-Puch]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Hartog]]></surname>
<given-names><![CDATA[CS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Opening the debate on the new sepsis definition change is not necessarily progress: revision of the sepsis definition should be based on new scientific insights]]></article-title>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2016</year>
<volume>194</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>16-8</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Salomao]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[BL]]></given-names>
</name>
<name>
<surname><![CDATA[Salomao]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Azevedo]]></surname>
<given-names><![CDATA[LCP]]></given-names>
</name>
<name>
<surname><![CDATA[Brunialti]]></surname>
<given-names><![CDATA[MKC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis: evolving concepts and challenges]]></article-title>
<source><![CDATA[Braz J Med Biol Res]]></source>
<year>2019</year>
<volume>52</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Singer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Deutschman]]></surname>
<given-names><![CDATA[CS]]></given-names>
</name>
<name>
<surname><![CDATA[Seymour]]></surname>
<given-names><![CDATA[CW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The third international consensus definitions for sepsis and septic shock (Sepsis-3)]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>2016</year>
<volume>315</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>801-10</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mierzchala-Pasierb]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Lipinska-Gediga]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis diagnosis and monitoring - procalcitonin as standard, but what next?]]></article-title>
<source><![CDATA[Anaesthesiol Intensive Ther]]></source>
<year>2019</year>
<volume>51</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>299-305</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Font]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Thyagarajan]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Khanna]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis and septic shock - basics of diagnosis, pathophysiology and clinical decision making]]></article-title>
<source><![CDATA[Med Clin North Am]]></source>
<year>2020</year>
<volume>104</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>573-85</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Evans]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Rhodes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Alhazzani]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021]]></article-title>
<source><![CDATA[Intensive Care Med]]></source>
<year>2021</year>
<volume>47</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1181-247</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arbo]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Lessing]]></surname>
<given-names><![CDATA[JK]]></given-names>
</name>
<name>
<surname><![CDATA[Ford]]></surname>
<given-names><![CDATA[WJH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heart rate variability measures for prediction of severity of illness and poor outcome in ED patients with sepsis]]></article-title>
<source><![CDATA[Am J Emerg Med]]></source>
<year>2020</year>
<volume>38</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>2607-13</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Samsudin]]></surname>
<given-names><![CDATA[MI]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Prabhakar]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A novel heart rate variability based risk prediction model for septic patients presenting to the emergency department]]></article-title>
<source><![CDATA[Medicine (Baltimore)]]></source>
<year>2018</year>
<volume>97</volume>
<numero>23</numero>
<issue>23</issue>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Chee]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Foo]]></surname>
<given-names><![CDATA[MZQ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heart rate n-variability (HRnV) measures for prediction of mortality in sepsis patients presenting at the emergency department]]></article-title>
<source><![CDATA[PLoS One]]></source>
<year>2021</year>
<volume>16</volume>
<numero>8</numero>
<issue>8</issue>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wee]]></surname>
<given-names><![CDATA[BYH]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Mok]]></surname>
<given-names><![CDATA[YH]]></given-names>
</name>
<name>
<surname><![CDATA[Chong]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A narrative review of heart rate and variability in sepsis]]></article-title>
<source><![CDATA[Ann Transl Med]]></source>
<year>2020</year>
<volume>8</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>768</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chiew]]></surname>
<given-names><![CDATA[CJ]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Ong]]></surname>
<given-names><![CDATA[MEH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serial heart rate variability measures for risk prediction of septic patients in the emergency department]]></article-title>
<source><![CDATA[AMIA Annu Symp Proc]]></source>
<year>2020</year>
<volume>2019</volume>
<page-range>285-94</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cygankiewicz]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Zareba]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heart rate variability]]></article-title>
<source><![CDATA[Handbook of clinical neurology]]></source>
<year>2013</year>
<page-range>379-93</page-range><publisher-loc><![CDATA[Amsterdam ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shaffer]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Ginsberg]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An overview of heart rate variability metrics and norms]]></article-title>
<source><![CDATA[Front Public Health]]></source>
<year>2017</year>
<volume>5</volume>
<page-range>258</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tiwari]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Malik]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Raj]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Analysis of heart rate variability and implication of different factors on heart rate variability]]></article-title>
<source><![CDATA[Curr Cardiol Rev]]></source>
<year>2021</year>
<volume>17</volume>
<numero>5</numero>
<issue>5</issue>
</nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alugubelli]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Abuissa]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Roka]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Wearable devices for remote monitoring of heart rate and heart rate variability-what we know and what is coming]]></article-title>
<source><![CDATA[Sensors (Basel)]]></source>
<year>2022</year>
<volume>22</volume>
<numero>22</numero>
<issue>22</issue>
<page-range>8903</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mageed]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
<name>
<surname><![CDATA[El Baser]]></surname>
<given-names><![CDATA[IIA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Predictive and prognostic value of heart rate variability analysis in early bedside diagnosis and management of COVID-19 patients]]></article-title>
<source><![CDATA[Anaest &amp; Sur Open Access J]]></source>
<year>2020</year>
<volume>1</volume>
<numero>5</numero>
<issue>5</issue>
</nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barnaby]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrick]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Kaplan]]></surname>
<given-names><![CDATA[DT]]></given-names>
</name>
<name>
<surname><![CDATA[Shah]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Bijur]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Gallagher]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heart rate variability in emergency department patients with sepsis]]></article-title>
<source><![CDATA[Acad Emerg Med]]></source>
<year>2002</year>
<volume>9</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>661-70</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barnaby]]></surname>
<given-names><![CDATA[DP]]></given-names>
</name>
<name>
<surname><![CDATA[Fernando]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrick]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Use of the low-frequency/high-frequency ratio of heart rate variability to predict short-term deterioration in emergency department patients with sepsis]]></article-title>
<source><![CDATA[Emerg Med J]]></source>
<year>2018</year>
<volume>35</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>96-102</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
