<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092022000800507</article-id>
<article-id pub-id-type="doi">10.35366/109171</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aclaramiento de lactato y déficit de base estándar como pronóstico de mortalidad en choque séptico]]></article-title>
<article-title xml:lang="en"><![CDATA[Lactate clearance and standard base deficit as a prognosis of mortality in septic shock]]></article-title>
<article-title xml:lang="pt"><![CDATA[Depuração de lactato e deficiência de base padrão como prognóstico de mortalidade no choque séptico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Mora]]></surname>
<given-names><![CDATA[Salvador]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza Rodríguez]]></surname>
<given-names><![CDATA[Martin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortes Munguía]]></surname>
<given-names><![CDATA[José Alfredo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López González]]></surname>
<given-names><![CDATA[Alfonso]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General La Villa  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>36</volume>
<numero>8</numero>
<fpage>507</fpage>
<lpage>513</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092022000800507&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092022000800507&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092022000800507&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  la asociación del nivel de lactato con la mortalidad en pacientes con sospecha de infección y sepsis está bien establecida. La sensibilidad es entre 66 y 83%, con especificidad de 80 y 85%. Sin embargo, el lactato no es sensible ni lo suficientemente específico para detectar o descartar el diagnóstico por sí solo, ya que el lactato sérico es un biomarcador importante de la hipoxia y disfunción tisular, pero no es una medida directa de la perfusión tisular. El lactato y la base estándar medidos al ingreso a la Unidad de Cuidados Intensivos (UCI) son de utilidad pronóstica en los pacientes críticamente enfermos, pues sus niveles séricos predicen mortalidad a través de la puntuación en sí misma. Pero la importancia real va más allá de un valor absoluto, pues es mejor medir su aclaramiento a través de un tiempo determinado.  Objetivo:  demostrar que el aclaramiento de lactato y déficit de base estándar registrados al ingreso y a las 24 h se relacionan con mejor pronóstico y disminución de mortalidad en choque séptico.  Material y métodos:  se utilizó estadística descriptiva (medidas de tendencia central y dispersión; así como frecuencias y porcentajes). Asimismo, se ocupó estadística inferencial con la prueba t de Student, &#967;2, curva ROC, área bajo la curva e índice de Youden, con un intervalo de confianza de 95%.  Resultados:  la asociación estadística con la mortalidad se presentó en el aclaramiento de déficit de base estándar y en aclaramiento de lactato.  Conclusión:  se demostró que el aclaramiento de lactato y déficit de base estándar registrados al ingreso y a las 24 h se relacionaron con mejor pronóstico y disminución de mortalidad en pacientes con choque séptico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  the association of lactate level with mortality in patients with suspected infection and sepsis is well established. Sensitivity is between 66 and 83%, with specificity between 80 and 85%. However, lactate is neither sensitive nor specific enough to detect or rule out the diagnosis on its own as serum lactate is an important biomarker of tissue hypoxia and dysfunction but is not a direct measure of tissue perfusion. Lactate and standard base measured on admission to the Intensive Care Unit (ICU) are useful for prognosis in critically ill patients since their serum levels predict mortality through the score itself. But the real importance goes beyond an absolute value, since it is better to measure its clearance over a given time.  Objective:  to demonstrate that lactate clearance and standard base deficit recorded at admission and at 24 hours are related to a better prognosis and decreased mortality in septic shock.  Material and methods:  descriptive statistics were used (measures of central tendency and dispersion, as well as frequencies and percentages). Likewise, inferential statistics were used with the Student&#8217;s t test, &#967;2, ROC curve, area under the curve and Youden index, with a confidence interval of 95%.  Results:  the statistical association with mortality was presented in the clearance of standard base deficit and in lactate clearance.  Conclusion:  it was shown that lactate clearance and standard base deficit recorded at admission and at 24 hours were related to a better prognosis and decreased mortality in patients with septic shock.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  a associação do nível de lactato com mortalidade em pacientes com suspeita de infecção e sepse está bem estabelecida. A sensibilidade está entre 66 e 83%, com especificidade de 80 e 85%. No entanto, o lactato não é sensível nem específico o suficiente para detectar ou descartar o diagnóstico por si só, uma vez que o lactato sérico é um importante biomarcador de hipóxia e disfunção tecidual, mas não é uma medida direta da perfusão tecidual. O lactato e a base padrão medidos na admissão na UTI são de utilidade prognóstica em pacientes críticos, uma vez que seus níveis séricos predizem a mortalidade pelo próprio escore. Mas a real importância vai além de um valor absoluto, pois é melhor medir sua depuração em um determinado tempo.  Objetivo:  demonstrar que a depuração de lactato e o déficit de base padrão registrados na admissão e em 24 horas estão relacionados a um melhor prognóstico e diminuição da mortalidade no choque séptico.  Material e métodos:  foi utilizada estatística descritiva (medidas de tendência central e dispersão, bem como frequências e percentagens). Da mesma forma, foi utilizada estatística inferencial com teste t de Student, &#967;2, curva ROC, área sob a curva e índice de Youden, com intervalo de confiança de 95%.  Resultados:  a associação estatística com a mortalidade foi apresentada na depuração do déficit de base padrão e na eliminação do lactato.  Conclusão:  foi demonstrado que a depuração de lactato e o déficit de base padrão registrados na admissão e em 24 horas foram relacionados a um melhor prognóstico e diminuição da mortalidade em pacientes com choque séptico.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[choque séptico]]></kwd>
<kwd lng="es"><![CDATA[gasometría arterial]]></kwd>
<kwd lng="es"><![CDATA[lactato]]></kwd>
<kwd lng="es"><![CDATA[déficit de base estándar]]></kwd>
<kwd lng="es"><![CDATA[aclaramiento]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[septic shock]]></kwd>
<kwd lng="en"><![CDATA[arterial blood gases]]></kwd>
<kwd lng="en"><![CDATA[lactate]]></kwd>
<kwd lng="en"><![CDATA[standard base deficit]]></kwd>
<kwd lng="en"><![CDATA[clearance]]></kwd>
<kwd lng="pt"><![CDATA[sepse]]></kwd>
<kwd lng="pt"><![CDATA[choque séptico]]></kwd>
<kwd lng="pt"><![CDATA[gasometría arterial]]></kwd>
<kwd lng="pt"><![CDATA[lactato]]></kwd>
<kwd lng="pt"><![CDATA[déficit de base padrão]]></kwd>
<kwd lng="pt"><![CDATA[depuração]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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