<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092017000500285</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Metahemoglobinemia severa secundaria a sobredosis de dapsona, reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Severe metahemoglobinemia associated with dapsone overdosis. Case report]]></article-title>
<article-title xml:lang="pt"><![CDATA[Metemoglobinemia severa secundária à sobredosagem de Dapsona, relato de um caso]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez Vega]]></surname>
<given-names><![CDATA[Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Franyuti Kelly]]></surname>
<given-names><![CDATA[Giorgio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hornelas Vargas]]></surname>
<given-names><![CDATA[Anapaula]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Ángeles Mocel  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2017</year>
</pub-date>
<volume>31</volume>
<numero>5</numero>
<fpage>285</fpage>
<lpage>287</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092017000500285&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092017000500285&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092017000500285&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La metahemoglobinemia es una entidad clínica causada por la oxidación de la hemoglobina (Hb), específicamente del grupo hemo, transforma el hierro de un estado ferroso (Fe2+) a férrico (Fe3+++), dando como resultado la metahemoglobina (MetHb), la cual no es capaz de realizar enlaces con el oxígeno (O2) y por lo tanto no puede trasportarlo, condicionando una disminución en la oxigenación tisular. La Hb puede oxidarse debido a alteraciones genéticas de expresión variable o más frecuentemente por efecto adverso de sustancias exógenas, destacando fármacos como la dapsona. Se describe el cuadro clínico, diagnóstico y tratamiento de una paciente con metahemoglobinemia adquirida por sobredosis de dapsona.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Methemoglobinemia is a clinical entity caused by oxidation of hemoglobin (Hb) specifically heme, transforming iron from a ferrous state (Fe2+) to a ferric state (Fe3+++), resulting in methemoglobin (MetHb), which is not capable of bonding with oxygen (O2), and therefore cannot transport it, conditioning tissue irrigation. Hb may oxidize due to variable expression genetic abnormalities expression, or more frequently, as an adverse effect related to exogenous substances, such as dapsone. This work describes the clinical picture, diagnosis and treatment of a patient with metahemoglobinemia-acquired secondary to dapsone overdose.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: A metemoglobinemia é uma entidade clínica causada pela oxidação da hemoglobina (Hb), especificamente do grupo heme, transformando o ferro de um estado ferroso (Fe2+) para um estado férrico (Fe3+++), dando como resultado a Meta-hemoglobina (MetHb), que não é capaz de fazer ligações com o oxigênio (O2) e, portanto, não pode transportá-lo, condicionando a diminuição na oxigenação tissular. A Hb pode oxidar-se devido a alterações genéticas de expressão variável, ou mais freqüentemente devido ao efeito adverso de substâncias exógenas, destacando drogas como a Dapsona. Descrevemos o quadro clínico, diagnóstico e tratamento de um paciente com metemoglobinemia adquirida por sobredosagem de dapsona.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Metahemoglobina]]></kwd>
<kwd lng="es"><![CDATA[metahemoglobinemia]]></kwd>
<kwd lng="es"><![CDATA[dapsona]]></kwd>
<kwd lng="es"><![CDATA[sobredosis de dapsona]]></kwd>
<kwd lng="en"><![CDATA[Methemoglobin]]></kwd>
<kwd lng="en"><![CDATA[methemoglobinemia]]></kwd>
<kwd lng="en"><![CDATA[dapsone]]></kwd>
<kwd lng="en"><![CDATA[dapsone overdose]]></kwd>
<kwd lng="pt"><![CDATA[Meta-hemoglobina]]></kwd>
<kwd lng="pt"><![CDATA[metemoglobinemia]]></kwd>
<kwd lng="pt"><![CDATA[dapsona]]></kwd>
<kwd lng="pt"><![CDATA[sobredosagem de dapsona]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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