<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-5691</journal-id>
<journal-title><![CDATA[Mundo nano. Revista interdisciplinaria en nanociencias y nanotecnología]]></journal-title>
<abbrev-journal-title><![CDATA[Mundo nano]]></abbrev-journal-title>
<issn>2448-5691</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Instituto de Ciencias Aplicadas y Tecnología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-56912021000200204</article-id>
<article-id pub-id-type="doi">10.22201/ceiich.24485691e.2021.27.69661</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Respuestas celulares de macrófagos a nanopartículas de óxidos metálicos]]></article-title>
<article-title xml:lang="en"><![CDATA[Macrophage cellular responses to metal oxide nanoparticles]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez-Araujo]]></surname>
<given-names><![CDATA[Melissa Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vázquez-Duhalt]]></surname>
<given-names><![CDATA[Rafael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Juárez-Moreno]]></surname>
<given-names><![CDATA[Karla Oyuki]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Investigación Científica y de Educación Superior de Ensenada  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México Centro de Nanociencias y Nanotecnología Departamento de Bionanotecnología]]></institution>
<addr-line><![CDATA[Ensenada Baja California]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>14</volume>
<numero>27</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-56912021000200204&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-56912021000200204&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-56912021000200204&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Recientemente las nanopartículas de óxidos metálicos han recibido especial atención por su amplio espectro de propiedades únicas que pueden tener múltiples aplicaciones en la investigación y la industria. Debido al incremento del mercado de la nanotecnología, se espera que en los próximos años la síntesis y el uso de nanomateriales aumente considerablemente, por lo cual es de vital importancia evaluar los efectos de la exposición de nanomateriales en sistemas biológicos. Por ello, la nanotoxicología tiene como objetivo evaluar la toxicidad de los nanomateriales, íntimamente ligada a sus parámetros fisicoquímicos como tamaño y forma, entre otros. En esta revisión, nos enfocamos en las respuestas celulares desencadenadas por macrófagos a causa de la exposición a nanopartículas de óxidos metálicos, pues los macrófagos son las primeras células en interaccionar con las nanopartículas una vez que ingresan al organismo, y tienen la habilidad de fagocitarlas por distintos mecanismos. La interacción con algunas nanopartículas óxido metálicas causan alteración en la expresión de genes que modulan el fenotipo y las funciones de los macrófagos. Esta modulación puede ser aprovechada para inmunoterapia contra el cáncer; sin embargo, es de suma importancia estudiar si esta modulación dirige a inmunotoxicidad, la cual impacta directamente de manera negativa en las funciones primordiales de los macrófagos y, por lo tanto, del sistema inmunológico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Recently, metal oxide nanoparticles received special attention due to their broad spectrum of unique properties with applications in research and industry. Because of to the raising of the nanotechnology market, the synthesis and use of nanomaterials are expected to increase considerably in the coming years. Thus, it is crucial to test the effects of nanomaterial exposure in biological systems. To achieve this, nanotoxicology aims to evaluate nanomaterials&#8217; toxicity that correlates to the physicochemical parameters such as size and shape. In this review, we focus on macrophages&#8217; cellular responses exerted by their exposure to metal oxide nanoparticles. Since macrophages are the first cells to interact with nanoparticles once they enter the body, they are able to uptake them by different mechanisms. The interaction with some metal oxide nanoparticles causes an alteration in the expression of genes that modulate macrophages&#8217; phenotype and functions. This modulation can be used for immunotherapy against cancer; however, it is of utmost importance to study whether this modulation leads to immunotoxicity, which directly impacts the primary functions of macrophages, and therefore the immune system.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[nanotoxicología]]></kwd>
<kwd lng="es"><![CDATA[macrófagos]]></kwd>
<kwd lng="es"><![CDATA[toxicidad]]></kwd>
<kwd lng="es"><![CDATA[nanopartículas de óxidos metálicos]]></kwd>
<kwd lng="en"><![CDATA[nanotoxicology]]></kwd>
<kwd lng="en"><![CDATA[macrophages]]></kwd>
<kwd lng="en"><![CDATA[toxicity]]></kwd>
<kwd lng="en"><![CDATA[oxide metallic nanoparticles]]></kwd>
</kwd-group>
</article-meta>
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<article-title xml:lang=""><![CDATA[Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues]]></article-title>
<source><![CDATA[Nature Nanotechnology]]></source>
<year>2016</year>
<volume>11</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>986-94</page-range></nlm-citation>
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