<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-5691</journal-id>
<journal-title><![CDATA[Mundo nano. Revista interdisciplinaria en nanociencias y nanotecnología]]></journal-title>
<abbrev-journal-title><![CDATA[Mundo nano]]></abbrev-journal-title>
<issn>2448-5691</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Instituto de Ciencias Aplicadas y Tecnología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-56912018000100027</article-id>
<article-id pub-id-type="doi">10.22201/ceiich.24485691e.2018.20.63062</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Perfil fisiológico de los nanomateriales]]></article-title>
<article-title xml:lang="en"><![CDATA[Physiological profile of nanomaterials]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Navarro-Tovar]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez Lee]]></surname>
<given-names><![CDATA[Manuel Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de San Luis Potosí Facultad de Ciencias Químicas ]]></institution>
<addr-line><![CDATA[ San Luis Potosí]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<volume>11</volume>
<numero>20</numero>
<fpage>27</fpage>
<lpage>41</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-56912018000100027&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-56912018000100027&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-56912018000100027&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El objetivo del presente trabajo es dar a conocer el fundamento y potencial aplicación de diversos modelos biológicos experimentales que nos han permitido conocer un poco más acerca del efecto de los nanomateriales (NMs) cuando ingresan e interaccionan en un tejido, órgano o sistema determinado y, con ello, establecer en tiempo real, el perfil fisiológico de un nanomaterial específico. Los resultados obtenidos de las técnicas y enfoques fisiológicos se obtienen de forma relativamente rápida, con un costo comparativamente bajo y proporcionan información importante sobre los mecanismos de acción involucrados en el órgano diana. En esta revisión, se describen algunos modelos fisiológicos que pueden aportar información relevante en nanotoxicología y cómo se podrían complementar a través de modelos in silico. Asi mismo, se presenta como ejemplo de estudio, el trabajo realizado por nuestro grupo de investigación en referencia al efecto biológico de las nanopartículas de plata (AgNPs) haciendo uso de sistemas fisiológicos como el de corazón aislado y perfundido, anillos aislados de vasos sanguíneos y de vías respiratorias.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: The objective of this work is to present the basis and potential application of various experimental biological models that have allowed us to know a little more about the effect of nanomaterials (NMs) when they enter and interact in a specific tissue, organ or system and, with it, establish in real time, the physiological profile of a determined nanomaterial. The results of these physiological techniques and approaches are obtained relatively fast, with relatively low cost and, provide important information related to the mechanisms of action involved in the target organ. In this review, we describe some physiological models that can provide relevant information in nano&#8211;toxicology and how they could be complemented through in silico models. Likewise, we display as an example of study associated to the biological effects induced by silver nanoparticles (AgNPs), using physiological systems such as isolated and perfused heart, isolated rings of blood vessels and respiratory tract.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[nanomateriales]]></kwd>
<kwd lng="es"><![CDATA[fisiología]]></kwd>
<kwd lng="es"><![CDATA[modelos biológicos]]></kwd>
<kwd lng="en"><![CDATA[nanomaterials]]></kwd>
<kwd lng="en"><![CDATA[physiology]]></kwd>
<kwd lng="en"><![CDATA[biological models]]></kwd>
</kwd-group>
</article-meta>
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