<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2306-4102</journal-id>
<journal-title><![CDATA[Acta ortopédica mexicana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta ortop. mex]]></abbrev-journal-title>
<issn>2306-4102</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Ortopedia y Traumatología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2306-41022023000600350</article-id>
<article-id pub-id-type="doi">10.35366/114161</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Clinical improvement after intraarticular and intraosseous injections of platelet rich plasma combined with hyaluronic acid for knee osteoarthritis. Case series]]></article-title>
<article-title xml:lang="es"><![CDATA[Mejoría clínica tras inyecciones intraarticulares e intraóseas de plasma rico en plaquetas combinado con ácido hialurónico para la artrosis de rodilla. Serie de casos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[EGE]]></surname>
<given-names><![CDATA[Araujo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Corral]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ochoa]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Clínica Anglo Americana  ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Médico Imbanaco  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundación Santa Fe de Bogotá Departamento de Ortopedia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Clínica Anglo Americana Departamento de Ortopedia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Centro Médico Imbanaco Departamento de Ortopedia ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>37</volume>
<numero>6</numero>
<fpage>350</fpage>
<lpage>355</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2306-41022023000600350&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2306-41022023000600350&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2306-41022023000600350&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  knee osteoarthritis (KOA) is known as the most common form of osteoarthrosis with a 6% prevalence in people over 30 years old, and more than 40% in the population over 70 years old. The use of PRP led to diverse results and this disparity can be attributed to the dissimilar methods of PRP preparation. This study aims to assess the functional effects of intraosseous (IO) and intraarticular (IA) injections of platelet rich plasma (PRP) followed by IA injections of hyaluronic acid (HA).  Objectives:  this study aimed to assess the functional effects of intraosseous (IO) and intraarticular (IA) injections of platelet rich plasma (PRP) followed by IA injections of hyaluronic acid (HA), administered 3 and 4 weeks after the initiation of treatment in 33 patients with grade II-III (Ahlback scale) knee osteoarthritis (KOA).  Material and methods:  retrospectively, 33 patients were assessed using the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index and visual analogue scale (VAS) score. They were followed-up for 12.92 months on average. Patients were divided into three groups based on age and four groups based on the follow-up period.  Results:  the pre-operative mean of the WOMAC index was 44.35 ± 20.20 and the post-operative mean was 22.81 ± 17.25 (p &lt; 0.001). The pre-operative and post-operative mean of the VAS scores were 5.79 ± 2.01 and 2.41 ± 1.43 (p &lt; 0.001), respectively. The largest improvement in WOMAC (from 42.86 to 13.69) was observed in the youngest patients (44 to 55 years old) and the largest reduction in VAS (from 6.89 to 2.22) was seen in patients aged 56 to 70 years.  Conclusion:  the combination of IO and IA plasma rich in growth factor (PRGF) treatment with the IA-HA treatment yielded excellent results, diminishing pain and improving motor functionality in patients with KOA.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción: la artrosis de rodilla (OA) es conocida como la forma más común de osteoartrosis con una prevalencia de 6% en personas mayores de 30 años y más de 40% en la población mayor de 70 años. El uso de plasma rico en plaquetas (PRP) condujo a resultados diversos y esta disparidad puede atribuirse a los diferentes métodos de preparación del PRP. Este estudio tiene como objetivo evaluar los efectos funcionales de las inyecciones intraóseas (IO) e intraarticulares (IA) de plasma rico en plaquetas (PRP) seguidas de inyecciones IA de ácido hialurónico (AH).  Objetivos:  este estudio tuvo como objetivo evaluar los efectos funcionales de las inyecciones intraóseas (IO) e intraarticulares (IA) de plasma rico en plaquetas (PRP) seguidas de inyecciones IA de ácido hialurónico (AH), administrada 3 y 4 semanas después del inicio del tratamiento en 33 pacientes con osteoartrosis de rodilla (OR) grado II-III (escala de Ahlbäck).  Material y métodos:  retrospectivamente, se evaluó a 33 pacientes utilizando el índice de osteoartritis de las Universidades Western Ontario y McMaster (WOMAC) y la puntuación de la escala visual analógica (EVA). Se les realizó un seguimiento medio de 12.92 meses. Los pacientes se dividieron en tres grupos según la edad y cuatro grupos según el período de seguimiento.  Resultados:  la media preoperatoria del índice WOMAC fue de 44.35 ± 20.20 y la media postoperatoria fue de 22.81 ± 17.25 (p &lt; 0.001). La media preoperatoria y postoperatoria de las puntuaciones de la EVA fue de 5.79 ± 2.01 y 2.41 ± 1.43 (p &lt; 0.001), respectivamente. La mayor mejoría en WOMAC (de 42.86 a 13.69) se observó en los pacientes más jóvenes (44 a 55 años) y la mayor reducción de la EVA (de 6.89 a 2.22) se observó en pacientes de 56 a 70 años.  Conclusión: la combinación del tratamiento de plasma rico en factores de crecimiento (PRGF) IO e IA con el tratamiento IA-AH produjo excelentes resultados, disminuyendo el dolor y mejorando la funcionalidad motora de los pacientes con OR.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[knee osteoarthritis]]></kwd>
<kwd lng="en"><![CDATA[rich in growth factor]]></kwd>
<kwd lng="en"><![CDATA[growth factors]]></kwd>
<kwd lng="en"><![CDATA[intraosseous infiltration]]></kwd>
<kwd lng="en"><![CDATA[hyaluronic acid]]></kwd>
<kwd lng="en"><![CDATA[intraarticular injection]]></kwd>
<kwd lng="es"><![CDATA[osteoartrosis de la rodilla]]></kwd>
<kwd lng="es"><![CDATA[plasma rico en factores de crecimiento]]></kwd>
<kwd lng="es"><![CDATA[factores de crecimiento]]></kwd>
<kwd lng="es"><![CDATA[infiltración intraósea]]></kwd>
<kwd lng="es"><![CDATA[ácido hialurónico]]></kwd>
<kwd lng="es"><![CDATA[infiltración intraarticular]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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<issue>9</issue>
<page-range>1520-9</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
