<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-8447</journal-id>
<journal-title><![CDATA[Revista biomédica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. biomédica]]></abbrev-journal-title>
<issn>2007-8447</issn>
<publisher>
<publisher-name><![CDATA[Universidad Autónoma de Yucatán, Centro de Investigaciones Regionales Dr. Hideyo Noguchi Naturaleza]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-84472016000200004</article-id>
<article-id pub-id-type="doi">10.32776/revbiomed.v27i2.26</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Detección del genotipo 1d del virus de la hepatitis E en pacientes con sospecha de hepatitis viral aguda, Cuba 2013]]></article-title>
<article-title xml:lang="en"><![CDATA[Detection of hepatitis E virus genotype 1d in patients with suspect of acute viral hepatitis in Cuba during 2013]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montalvo-Villalba]]></surname>
<given-names><![CDATA[María Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castellano-Girones]]></surname>
<given-names><![CDATA[Yoandris]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bello-Corredor]]></surname>
<given-names><![CDATA[Marité]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Lay]]></surname>
<given-names><![CDATA[Licel de los Ángeles]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Medicina Tropical Pedro Kouri Departamento de Virología Subdirección de Microbiología]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2016</year>
</pub-date>
<volume>27</volume>
<numero>2</numero>
<fpage>75</fpage>
<lpage>83</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-84472016000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-84472016000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-84472016000200004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción El virus de la hepatitis E (VHE) se transmite, principalmente, por vía fecal-oral y es una de las principales causas de hepatitis viral aguda (HVA) en el mundo. En Cuba, a pesar de que este virus tiene un comportamiento endémico, no se relaciona a este patógeno al presentarse una hepatitis viral de trasmisión entérica.  Objetivo Teniendo en cuenta que el VHE y el virus de la hepatitis A (VHA) comparten rutas de transmisión, nos propusimos estimar la incidencia de ésta infección (VHE), en muestras que se recibieron de todo el país durante el año 2013, cuyo criterio de inclusión fue la indicación médica de IgM anti-VHA.  Materiales y Métodos Se empleó la RT-PCR específica para el marco abierto de lectura 2 (MAL2), con el propósito de detectar el ARN-VHE en las 422 muestras estudiadas. Los productos amplificados fueron purificados, secuenciados y analizados filogenéticamente con el programa MEGA6.  Resultados La presencia de ARN-VHE se detectó en 8,53% (36/422) de las muestras estudiadas. El mayor índice de positividad se identificó en la región occidental del país, específicamente en La Habana con 5,45% (23/422). En total se diagnosticaron 5,21% (22/422) muestras positivas al marcador de IgM VHA; la detección simultánea de marcadores del VHA-VHE fue 13,88% (5/36). Los resultados demuestran una mayor incidencia del VHE con respecto al VHA (8,53% vs 5,21%) y el análisis filogenético mostró la circulación del genotipo 1, subgenotipo 1d del VHE.  Conclusiones Se corroboró la endemicidad del VHE en nuestro país y, por primera vez, se identificó el subgenotipo 1d, variante africana asociada a casos esporádicos y brotes de hepatitis E.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction Hepatitis E virus (HEV) is mainly transmitted by the fecal-oral route and is one of the most important causes of acute viral hepatitis (AVH) around the world. In Cuba, Despite of endemic behavior of HEV in Cuba, its causality is not associated when a picture of enteric acute hepatitis is suspected.  Objective Taking into account the common transmission route of both HEV and HAV, our aim was to estimate the incidence of HEV infection in sera samples received throughout the country during 2013 where the IgM anti-HAV test was required by the Clinician.  Materials and Methods A specific RT-PCR for open reading frame 2 (ORF2) was used to detect RNA-HEV in 422 sera. The amplified products corresponding to ORF2 were purified, sequenced and phylogenetically analyzed using MEGA6 software program.  Results RNA-HEV was detected in 8.53% (36/422) of the samples. The highest rate of positivity was identified in the Western region of the country, specifically in Havana 5.45% (23/422). IgM anti-HAV was detected in 5.21% (22/422) and simultaneous detection of both HAV and HEV was found in 13.88% (5/36) of the samples. The results showed a higher incidence of HEV with respect to HAV (8.53% vs 5.21%) and phylogenetic analysis showed the circulation of genotype 1, subgenotype 1d of the HEV.  Conclusions This study corroborated the endemicity of HEV and for the first time the subgenotype 1d, the African variant strain associated to outbreak of hepatitis E, is reported in viral hepatitis cases in Cuba.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[epidemiología]]></kwd>
<kwd lng="es"><![CDATA[RT-PCR]]></kwd>
<kwd lng="es"><![CDATA[VHE]]></kwd>
<kwd lng="es"><![CDATA[VHA]]></kwd>
<kwd lng="es"><![CDATA[genotipo]]></kwd>
<kwd lng="en"><![CDATA[Epidemiology]]></kwd>
<kwd lng="en"><![CDATA[RT-PCR]]></kwd>
<kwd lng="en"><![CDATA[HEV]]></kwd>
<kwd lng="en"><![CDATA[HAV]]></kwd>
<kwd lng="en"><![CDATA[genotype]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ahmad]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Holla]]></surname>
<given-names><![CDATA[RP]]></given-names>
</name>
<name>
<surname><![CDATA[Jameel]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular virology of hepatitis E virus]]></article-title>
<source><![CDATA[Virus Res]]></source>
<year>2011</year>
<volume>161</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>47-58</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pavio]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Meng]]></surname>
<given-names><![CDATA[XJ]]></given-names>
</name>
<name>
<surname><![CDATA[Renou]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Zoonotic hepatitis E: animal reservoirs and emerging risks]]></article-title>
<source><![CDATA[Vet Res]]></source>
<year>2010</year>
<volume>41</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>46</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Teshale]]></surname>
<given-names><![CDATA[EH]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E: Epidemiology and prevention]]></article-title>
<source><![CDATA[World J Hepatol]]></source>
<year>2012</year>
<volume>3</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>285-91</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Purcell]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
<name>
<surname><![CDATA[Emerson]]></surname>
<given-names><![CDATA[SU]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E: an emerging awareness of an old disease]]></article-title>
<source><![CDATA[J Hepatol]]></source>
<year>2008</year>
<volume>48</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>494-503</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[DB]]></given-names>
</name>
<name>
<surname><![CDATA[Simmonds]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Jameel]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Emerson]]></surname>
<given-names><![CDATA[SU]]></given-names>
</name>
<name>
<surname><![CDATA[Harrison]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
<name>
<surname><![CDATA[Meng]]></surname>
<given-names><![CDATA[XJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Consensus proposals for classification of the family Hepeviridae]]></article-title>
<source><![CDATA[J Gen Virol]]></source>
<year>2014</year>
<volume>95</volume>
<page-range>2223-32</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Emerson]]></surname>
<given-names><![CDATA[SU]]></given-names>
</name>
<name>
<surname><![CDATA[Purcell]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E virus]]></article-title>
<source><![CDATA[Rev Med Virol]]></source>
<year>2003</year>
<volume>13</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>145-54</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khudyakov]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Kamili]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serological diagnostics of hepatitis E virus infection]]></article-title>
<source><![CDATA[Virus Res]]></source>
<year>2011</year>
<volume>161</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>84-92</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aggarwal]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Jameel]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>2011</year>
<volume>54</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>2218-26</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kamar]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Bendall]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Legrand-Abravanel]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Xia]]></surname>
<given-names><![CDATA[NS]]></given-names>
</name>
<name>
<surname><![CDATA[Ijaz]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Izopet]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2012</year>
<volume>379</volume>
<numero>9835</numero>
<issue>9835</issue>
<page-range>2477-88</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Quintana]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sanchez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Larralde]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Anderson]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalence of antibodies to hepatitis E virus in residents of a district in Havana, Cuba]]></article-title>
<source><![CDATA[J Med Virol]]></source>
<year>2005</year>
<volume>76</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>69-70</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodriguez Lay L de]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Quintana]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Villalba]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Lemos]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Corredor]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Moreno]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dual infection with hepatitis A and E viruses in outbreaks and in sporadic clinical cases: Cuba 1998-2003]]></article-title>
<source><![CDATA[J Med Virol]]></source>
<year>2008</year>
<volume>80</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>798-802</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schlauder]]></surname>
<given-names><![CDATA[GG]]></given-names>
</name>
<name>
<surname><![CDATA[Desai]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Zanetti]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
<name>
<surname><![CDATA[Tassopoulos]]></surname>
<given-names><![CDATA[NC]]></given-names>
</name>
<name>
<surname><![CDATA[Mushahwar]]></surname>
<given-names><![CDATA[IK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Novel hepatitis E virus (HEV) isolates from Europe: evidence for additional genotypes of HEV]]></article-title>
<source><![CDATA[J Med Virol]]></source>
<year>1999</year>
<volume>57</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>243-51</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Larkin]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Blackshiels]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[NP]]></given-names>
</name>
<name>
<surname><![CDATA[Chena]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[McGettigan]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
<name>
<surname><![CDATA[MacWillian]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clustal W and Clustal X vesions 2.0]]></article-title>
<source><![CDATA[Bioinformatics]]></source>
<year>2007</year>
<volume>23</volume>
<numero>2947-2948</numero>
<issue>2947-2948</issue>
</nlm-citation>
</ref>
<ref id="B14">
<label>14.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tamura]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Stecher]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Patersson]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Filipski]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[MEGA6: Molecular Evolutionary Genetic Analysis version 6.0]]></article-title>
<source><![CDATA[Mol Biol Evol]]></source>
<year>2013</year>
<volume>30</volume>
<numero>2725-2729</numero>
<issue>2725-2729</issue>
</nlm-citation>
</ref>
<ref id="B15">
<label>15.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Romano]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Paladini]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Tagliacarne]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Canuti]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bianchi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Zanetti]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E in Italy: A long-term prospective study]]></article-title>
<source><![CDATA[J Hepatol]]></source>
<year>2011</year>
<volume>54</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>34-40</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kamar]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Bendall]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Legrand-Abravanel]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Xia]]></surname>
<given-names><![CDATA[NS]]></given-names>
</name>
<name>
<surname><![CDATA[Ijaz]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Izopet]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2012</year>
<volume>379</volume>
<numero>9835</numero>
<issue>9835</issue>
<page-range>2477-88</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Panda]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Thakral]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Rehman]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E virus]]></article-title>
<source><![CDATA[Rev Med Virol]]></source>
<year>2007</year>
<volume>17</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>151-80</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Villalba]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Guan]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Perez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Corredor]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Frometa]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Moreno]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Seroprevalence of antibodies to hepatitis E virus in two large communities in Havana, Cuba]]></article-title>
<source><![CDATA[Trans R Soc Trop Med Hyg]]></source>
<year>2010</year>
<volume>104</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>772-6</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de la Caridad Montalvo Villalba]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Owot]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Corrreia]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Corredor]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Flaquet]]></surname>
<given-names><![CDATA[PP]]></given-names>
</name>
<name>
<surname><![CDATA[Frometa]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E virus genotype 3 in humans and swine, Cuba]]></article-title>
<source><![CDATA[Infect Genet Evol]]></source>
<year>2013</year>
<volume>14</volume>
<page-range>335-9</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ippagunta]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Naik]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Aggarwal]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Presence of hepatitis E virus in sewage in Northern India: frequency and seasonal pattern]]></article-title>
<source><![CDATA[J Med Virol]]></source>
<year>2007</year>
<volume>79</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1827-31</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Pan]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Baloch]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
<name>
<surname><![CDATA[Tian]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Na]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E virus genotype 4 in yak, northwestern China]]></article-title>
<source><![CDATA[Emerg Infect Dis]]></source>
<year>2014</year>
<volume>20</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>2182-4</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Juhl]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Baylis]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Blumel]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Gorg]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hennig]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Seroprevalence and incidence of hepatitis E virus infection in German blood donors]]></article-title>
<source><![CDATA[Transfusion]]></source>
<year>2014</year>
<volume>54</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>49-56</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Galiana]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez-Barredo]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Perez-Gracia]]></surname>
<given-names><![CDATA[MT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalence of hepatitis E virus (HEV) and risk factors in pig workers and blood donors]]></article-title>
<source><![CDATA[Enferm Infecc Microbiol Clin]]></source>
<year>2010</year>
<volume>28</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>602-7</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24.</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Villalba-Montalvo]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
</person-group>
<source><![CDATA[Evidencias serologicas y moleculares de la circulacion del virus de la hepatitis E en Cuba]]></source>
<year>2011</year>
<publisher-name><![CDATA[Instituto de Medicina Tropical "Pedro Kouri", Departamento de Virología]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B25">
<label>25.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Toole]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Claridge]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Anderson]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Zhuang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Morgan]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Otto]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E virus infection as a marker for contaminated community drinking water sources in Tibetan villages]]></article-title>
<source><![CDATA[Am J Trop Med Hyg]]></source>
<year>2006</year>
<volume>74</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>250-4</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Qu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Seroepidemiology and molecular characterization of hepatitis E virus in Jilin, China]]></article-title>
<source><![CDATA[Infection]]></source>
<year>2008</year>
<volume>36</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>140-6</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ren]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Shen]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Cui]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Fan]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E virus infection in central China reveals no evidence of cross-species transmission between human and swine in this area]]></article-title>
<source><![CDATA[PLoS One]]></source>
<year>2009</year>
<volume>4</volume>
<numero>12</numero>
<issue>12</issue>
</nlm-citation>
</ref>
<ref id="B28">
<label>28.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stoszek]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Abdel-Hamid]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Saleh]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[El Kafrawy]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Narooz]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hawash]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[High prevalence of hepatitis E antibodies in pregnant Egyptian women]]></article-title>
<source><![CDATA[Trans R Soc Trop Med Hyg]]></source>
<year>2006</year>
<volume>100</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>95-101</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Beniwal]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Jilani]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[JB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalence and severity of acute viral hepatitis and fulminant hepatitis during pregnancy: A prospective study from north India]]></article-title>
<source><![CDATA[Indian J Med Microbiol]]></source>
<year>2003</year>
<volume>21</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>184-5</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Munne]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Vladimirsky]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Otegui]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Brajterman]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Castro]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Soto]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular characterization of hepatitis E virus in three acute liver failure cases in children in Argentina]]></article-title>
<source><![CDATA[Acta Gastroenterol Latinoam]]></source>
<year>2006</year>
<volume>36</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>125-30</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Samanta]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Ganguly]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aetiology, clinical profile and prognostic indicators for children with acute liver failure admitted in a teaching hospital in Kolkata]]></article-title>
<source><![CDATA[Trop Gastroenterol]]></source>
<year>2007</year>
<volume>28</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>135-9</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mahtab]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Rahman]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Khan]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mamun]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Afroz]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Etiology of fulminant hepatic failure: experience from a tertiary hospital in Bangladesh]]></article-title>
<source><![CDATA[Hepatobiliary Pancreat Dis Int]]></source>
<year>2008</year>
<volume>7</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>161-4</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Meng]]></surname>
<given-names><![CDATA[XJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recent advances in Hepatitis E virus]]></article-title>
<source><![CDATA[J Viral Hepat]]></source>
<year>2009</year>
<volume>17</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>153-61</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Keane]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Gompels]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bendall]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Drayton]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Jennings]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Black]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E virus coinfection in patients with HIV infection]]></article-title>
<source><![CDATA[HIV Med]]></source>
<year>2012</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>83-8</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chow]]></surname>
<given-names><![CDATA[WC]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[Lim]]></surname>
<given-names><![CDATA[GK]]></given-names>
</name>
<name>
<surname><![CDATA[Cheong]]></surname>
<given-names><![CDATA[WK]]></given-names>
</name>
<name>
<surname><![CDATA[Chong]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[CK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acute viral hepatitis E: clinical and serologic studies in Singapore]]></article-title>
<source><![CDATA[J Clin Gastroenterol]]></source>
<year>1997</year>
<volume>24</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>235-8</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alam]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Azam]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Mustafa]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Azad]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Haque]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Gani]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Natural course of fulminant hepatic failure: the scenario in Bangladesh and the differences from the west]]></article-title>
<source><![CDATA[Saudi J Gastroenterol]]></source>
<year>2009</year>
<volume>15</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>229-33</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zaki Mel]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Salama]]></surname>
<given-names><![CDATA[OS]]></given-names>
</name>
<name>
<surname><![CDATA[Mansour]]></surname>
<given-names><![CDATA[FA]]></given-names>
</name>
<name>
<surname><![CDATA[Hossein]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E virus coinfection with hepatotropic viruses in Egyptian children]]></article-title>
<source><![CDATA[J Microbiol Immunol Infect]]></source>
<year>2008</year>
<volume>41</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>254-8</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Villalba]]></surname>
<given-names><![CDATA[M de L]]></given-names>
</name>
<name>
<surname><![CDATA[Lay L de]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Chandra]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Corredor]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Frometa]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Moreno]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hepatitis E virus genotype 1, Cuba]]></article-title>
<source><![CDATA[Emerg Infect Dis]]></source>
<year>2008</year>
<volume>14</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1320-2</page-range></nlm-citation>
</ref>
<ref id="B39">
<label>39.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fan]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Open reading frame structure analysis as a novel genotyping tool for hepatitis E virus and the subsequent discovery of an inter-genotype recombinant]]></article-title>
<source><![CDATA[J Gen Virol]]></source>
<year>2009</year>
<volume>90</volume>
<page-range>1353-8</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>40.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aguiar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comportamiento Epidemiológico de la Hepatitis A en Cuba]]></article-title>
<source><![CDATA[Reporte Técnico Vigilancia]]></source>
<year>2004</year>
<volume>9</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1-7</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
