<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-7459</journal-id>
<journal-title><![CDATA[Horizonte sanitario]]></journal-title>
<abbrev-journal-title><![CDATA[Horiz. sanitario]]></abbrev-journal-title>
<issn>2007-7459</issn>
<publisher>
<publisher-name><![CDATA[Universidad Juárez Autónoma de Tabasco, División Académica de Ciencias de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-74592021000300343</article-id>
<article-id pub-id-type="doi">10.19136/hs.a20n3.4297</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estudio preliminar de un enjuague bucal de solución salina como muestra diagnóstica para SARS-CoV-2]]></article-title>
<article-title xml:lang="en"><![CDATA[Preliminary study of a saline mouthwash as a diagnostic sample for SARS-CoV-2]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Suarez-Mendez]]></surname>
<given-names><![CDATA[Samuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Vázquez]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valle-Laveaga]]></surname>
<given-names><![CDATA[David del]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Juárez-Rojop]]></surname>
<given-names><![CDATA[Isela Esther]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz-Quiñones]]></surname>
<given-names><![CDATA[Jesús Arturo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Juárez Autónoma de Tabasco Centro de Investigación de Enfermedades Tropicales y Emergentes. ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Investigación de Enfermedades Tropicales y Emergentes.  ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Juárez Autónoma de Tabasco Centro de Investigación de Enfermedades Tropicales y Emergentes ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Juárez Autónoma de Tabasco  ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital Regional de Alta Especialidad &#8220;Dr. Juan Graham Casasús&#8221;  ]]></institution>
<addr-line><![CDATA[Villahermosa, Tabasco]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>20</volume>
<numero>3</numero>
<fpage>343</fpage>
<lpage>347</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-74592021000300343&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-74592021000300343&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-74592021000300343&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo:  Evaluar la utilidad de un enjuague bucal con solución salina (EBSS) como muestra diagnóstica para la detección de SARS-CoV-2 en pacientes ambulatorios.  Material y métodos:  Este fue un estudio prospectivo realizado en el Hospital Regional de Alta Especialidad &#8220;Dr. Juan Graham Casasús&#8221;, se seleccionaron 34 muestras aleatorias pareadas EBSS/MNF (enjuague bucal con solución salina/muestra (clínica) de la nasofaringe) que se recolectaron durante la visita al centro de evaluación ambulatoria de dicho hospital. Las muestras se analizaron mediante la reacción en cadena de la polimerasa con transcripción inversa en tiempo real (RT-PCR) y se calculó la concordancia entre EBSS y MNF, la sensibilidad y especificidad del EBSS.  Resultados:  De las 34 muestras pareadas EBSS/MNF, 14 fueron positivas para SARS- CoV-2; 4 muestras de EBSS y 10 muestras de MNF. Los resultados concordantemente positivos en las muestras pareadas EBSS/MNF fueron 3 y las medias de CT de cada gen (RdRp, N, E) no mostraron diferencia significativa entre las muestras. Se observaron 8 discordancias entre los dos tipos de muestras (7 individuos dieron positivo por MNF y 1 por EBSS). La concordancia observada entre EBSS y MNF fue aceptable (coeficiente kappa 0.31). La sensibilidad de EBSS fue de 30% con una especificidad del 95.8%.  Conclusiones:  La sensibilidad de EBSS no es comparable con la sensibilidad de MNF para la detección de SARS-CoV-2, pero nuestros datos sugieren al EBSS como una herramienta no invasiva, permite la autocolección y no requiere personal de salud capacitado para su muestreo: asimismo, esta muestra podría ser alternativa ante la escasez de hisopos y medios de transporte viral. Además, el EBSS puede tener beneficio para poblaciones remotas, vulnerables o facilitar las pruebas a un gran número de individuos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective:  To assess the usefulness of a saline mouth rinse (SMR) as a diagnostic tool for the detection of SARS-CoV-2 in outpatients.  Method:  This was a prospective study carried out at the Hospital Regional de Alta Especialidad &#8220;Dr. Juan Graham Casasús&#8221;, 34 SMR/SNP (saline mouth rinse/sample (clinical) of nasopharyngeal) randomized paired samples were selected and collected in the outpatient clinic. The samples were analyzed by real-time reverse transcription polymerase chain reaction (RT-PCR) and the concordance between SMRs and SNP samples and the sensitivity and specificity of SMR were calculated.  Results:  Out of the 34 SMR/SNP paired samples, 14 samples were positive for SARS- CoV-2; 4 SMR samples and 10 SNP samples. We found 3 positive concordant results in the SMRs/SNP paired samples, the mean CT for each gene (RdRp, N, E) did not show a significant difference between the samples. Eight discrepancies were observed between the two types of samples (7 individuals were positive by SNP and 1 for SMR). The concordance observed between SMR and SNP was acceptable (kappa coefficient 0.31). The sensitivity of EBSS was 30% with a specificity of 95.8%.  Conclusions:  The SMR sensitivity is not comparable with SNP sensitivity for SARS- CoV-2 detection, but our data suggest SMR as a non-invasive tool that allows self- collection, and it does not require health trained personnel for its collection. Also, this sample could be an alternative to the lack of swabs and/or viral transportation media. Additionally, SMR may be of benefit in remote and vulnerable populations, and/or to facilitate the screening of SARS-CoV-2 in a large number of individuals.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[Coronavirus]]></kwd>
<kwd lng="es"><![CDATA[Enjuague bucal]]></kwd>
<kwd lng="es"><![CDATA[sensibilidad.]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[Coronavirus]]></kwd>
<kwd lng="en"><![CDATA[Mouthwashes]]></kwd>
<kwd lng="en"><![CDATA[Sensitivity.]]></kwd>
</kwd-group>
</article-meta>
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