<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-1124</journal-id>
<journal-title><![CDATA[Revista mexicana de ciencias pecuarias]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. de cienc. pecuarias]]></abbrev-journal-title>
<issn>2007-1124</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-11242022000200391</article-id>
<article-id pub-id-type="doi">10.22319/rmcp.v13i2.5942</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Pharmacokinetic analysis of intraarticular injection of insulin and its effect on IGF-1 expression in synovial fluid of healthy horses]]></article-title>
<article-title xml:lang="es"><![CDATA[Análisis farmacocinético de la inyección intraarticular de insulina y su efecto sobre la expresión del IGF-1 en el líquido sinovial de caballos sanos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Lacy]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez-Olvera]]></surname>
<given-names><![CDATA[Lilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bernad]]></surname>
<given-names><![CDATA[María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fortier]]></surname>
<given-names><![CDATA[Lisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Trigo-Tavera]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Chavarín]]></surname>
<given-names><![CDATA[Margarita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Monterde]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Veterinaria y Zootecnia ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Veterinaria y Zootecnia Departamento de Fisiología y Farmacología]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,UNAM Facultad de Química Departamento de Farmacia]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Cornell University  ]]></institution>
<addr-line><![CDATA[Ithaca ]]></addr-line>
<country>USA</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Veterinaria y Zootecnia Departamento de Patología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af6">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Depto. Fisiología]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina Veterinaria y Zootecnia ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>13</volume>
<numero>2</numero>
<fpage>391</fpage>
<lpage>407</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-11242022000200391&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-11242022000200391&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-11242022000200391&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Insulin induces mitosis on equine chondrocytes in vitro and enhances production of type II collagen. Insulin, when administered intra-articularly, changes the composition of synovial fluid, including the concentrations of glucose, insulin and glycemia levels. The concentration of insulin in the joint was measured by using high-performance liquid chromatography (HPLC), which provided pharmacokinetic values. Six mixed breed horses were administered three different doses of insulin into one antebrachiocarpal joint (10, 15 and 20 IU) and isotonic saline was administered into the contralateral joint. The blood glucose concentration significantly changed through time for all three doses (P&lt;0.0001). No significant differences in protein concentration and cell count in synovial fluid were found between treated and control joints (P&gt;0.05), no significant difference in synovial glucose concentrations was found between treated and control joints (P&gt;0.05). Values obtained by HPLC analyzed with PkAnalyst program revealed that the pharmacokinetic values were dose dependent, there was no significant difference in concentration of blood glucose between the three different doses (P&gt;0.05). ELISA for IGF-1 (insulin-like growth factor 1) revealed a significant difference between treated and control joints (P&lt;0.001). Insulin used in this study proved to be innocuous to the equine joint, no more than 20 IU for a 350-400 kg horse should be administered.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La insulina induce la mitosis en los condrocitos equinos in vitro y mejora la producción de colágeno tipo II. La insulina, cuando se administra vía intraarticular, cambia la composición del líquido sinovial, incluyendo las concentraciones de glucosa, insulina y los niveles de glucemia. La concentración de insulina en la articulación se midió mediante cromatografía líquida de alta resolución (HPLC, por sus siglas en inglés), que proporcionó valores farmacocinéticos. A seis caballos de raza mixta se les administraron tres dosis diferentes de insulina en una articulación antebraquiocarpiana (10, 15 y 20 UI) y se administró solución salina isotónica en la articulación contralateral. La concentración de glucosa en sangre cambió significativamente a través del tiempo para las tres dosis (P&lt;0.0001). No se encontraron diferencias significativas en la concentración de proteínas y el recuento celular en el líquido sinovial entre las articulaciones tratadas y de control (P&gt;0.05), no se encontró diferencia significativa en las concentraciones de glucosa sinovial entre las articulaciones tratadas y de control (P&gt;0.05). Los valores obtenidos mediante HPLC se analizaron con PKAnalyst, esto reveló que los valores farmacocinéticos eran dependientes de las dosis, no hubo diferencia significativa en la concentración de glucosa en sangre entre las tres diferentes dosis (P&gt;0.05). ELISA para el IGF-1 (factor de crecimiento similar a la insulina 1) reveló una diferencia significativa entre las articulaciones tratadas y de control (P&lt;0.001). La insulina utilizada en este estudio demostró ser inocua para la articulación equina, no se deben administrar más de 20 UI para un caballo de 350-400 kg.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Insulin]]></kwd>
<kwd lng="en"><![CDATA[Intraarticular]]></kwd>
<kwd lng="en"><![CDATA[Horse]]></kwd>
<kwd lng="en"><![CDATA[IGF-1]]></kwd>
<kwd lng="en"><![CDATA[HPLC]]></kwd>
<kwd lng="es"><![CDATA[Insulina]]></kwd>
<kwd lng="es"><![CDATA[Intraarticular]]></kwd>
<kwd lng="es"><![CDATA[Caballo]]></kwd>
<kwd lng="es"><![CDATA[IGF-1]]></kwd>
<kwd lng="es"><![CDATA[HPLC]]></kwd>
</kwd-group>
</article-meta>
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