Secondary Metabolites from Heliotropium angiospermum

Gilda Erosa–Rejón,¹ Luis M. Peña–Rodríguez,² and Olov Sterner^1*

¹ Division of Organic Chemistry, Lund University, PO Box 124, SE–22100, Lund, Sweden. ^*Responsible author: Olov.Sterner@organic.lu.se

² Grupo de Química Orgánica, Unidad de Biotecnología, Centro de Investigación Científica de Yucatán. Calle 43 #130 Col. Chuburná de Hidalgo, Mérida, Yucatán, México 97200.

Received October 17, 2008 ]]> Accepted June 22, 2009

Abstract

Blumenol A (1), blumenol B (2) and loliolide (3), together with the ubiquitous β–sitosterol, α–amyrin and β–amyrin, were isolated from the organic extract of the leaves of Heliotropium angiospermum. Structural elucidation of the metabolites was carried out by analysis of their spectroscopic data and/or by comparison with those reported in the literature.

Key words: Heliotropium angiospermum, Boraginaceae, blumenol A, blumenol B, loliolide.

Resumen

Blumenol A, blumenol B y loliólido, además de β–sitosterol, α–amirina y β–amirina, fueron aislados del extracto orgánico de las hojas de Heliotropium angiospermum. La elucidación estructural de los metabolitos se llevó a cabo mediante la interpretación de sus datos espectroscópicos y/o por comparación de los mismos con los reportados en la literatura.

Palabras clave: Heliotropium angiospermum, Boraginaceae, blumenol A, blumenol B y loliólido.

Acknowledgements

The authors wish to thank Paulino Simá–Polanco and Francisco–Cen–Pacheco for collecting, identifying and preparing the plant material, as well as Fabiola Escalante–Erosa and Karlina García–Sosa, for technical assistance. G. E.–R. wishes to thank the EULADIV Alfa Project for supporting her research stays at CICY. The authors also gratefully acknowledge financial support from the Swedish Natural Science Research Council, the KAW foundation, the Swedish Foundation for International Cooperation in Research and Higher Education, and FOMIX–Yucatán Project No. 66262.

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