<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-199X</journal-id>
<journal-title><![CDATA[Revista odontológica mexicana]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Odont. Mex]]></abbrev-journal-title>
<issn>1870-199X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Odontología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-199X2008000300149</article-id>
<article-id pub-id-type="doi">10.22201/fo.1870199xp.2008.12.3.15668</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Respuesta terapéutica de la pilocarpina en relación a la xerostomía inducida por radioterapia]]></article-title>
<article-title xml:lang="en"><![CDATA[Therapeutics response of pilocarpine related to xerostomy induced by radiotherapy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández López]]></surname>
<given-names><![CDATA[Rocío Gloria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortés Alonzo]]></surname>
<given-names><![CDATA[Nicté Zazil]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ochoa Carrillo]]></surname>
<given-names><![CDATA[Francisco Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Poitevin Chacón]]></surname>
<given-names><![CDATA[María Adela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Tejada]]></surname>
<given-names><![CDATA[Haroldo Elorza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UNAM FO ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UNAM  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Cancerología  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,UNAM FO ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2008</year>
</pub-date>
<volume>12</volume>
<numero>3</numero>
<fpage>149</fpage>
<lpage>153</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-199X2008000300149&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-199X2008000300149&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-199X2008000300149&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El objetivo del estudio fue evaluar la respuesta de la pilocarpina en la xerostomia inducida por radioterapia en cabeza y cuello. El diseño de estudio fue descriptivo, prospectivo de corte longitudinal, doble ciego. Los pacientes se distribuyeron aleatoriamente en dos grupos. El grupo 1 (n = 10) de control recibió placebo. Al grupo 2 (n = 10) de estudio se le administró 5 mg diarios de pilocarpina cada 8 h por vía oral. Se realizaron tres cuantificaciones del flujo salival; al inicio del tratamiento, a la quinta y a la séptima semana, por el método de diferenciación de pesos. En la primera cuantificación, al inicio del tratamiento de radioterapia, los pacientes no habían recibido ningún tipo de medicamento, en ningún grupo. Comparando ambos grupos se obtuvo t = 0.525, &#929; = 0.606, por lo que no existía diferencia estadísticamente significativa, en el flujo salival. A la quinta semana se observó en ambos grupos disminución del flujo salival, comparándolos se obtuvo t = 0.481, &#929; = 0.636, por lo que no se encontró diferencia estadísticamente significativa. Sin embargo, el grupo de estudio tuvo un incremento estadísticamente significativo a la séptima semana , del flujo salival, donde se obtuvo una media 0.651 y d.s 0.380, mientras el grupo control mostró una media 0.256, d.s 0.251 al aplicar una t de student se obtuvo t = 2.743, &#961; = de 0.013. Concluyendo que la pilocarpina es un tratamiento alternativo, viable, seguro y econòmico, para la xerostomia inducida por radioterapia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The objective of this study was to evaluate the response of pilocarpine in patients with xerostomy induced by radiotherapy in head and neck. Twenty patients of the Instituto Nacional de Cancerologia (INCan) participated. A randomized, prospective and longitudinal study was carried out. The control group (n = 10) received a placebo. The study group (n = 10) was medicated daily with 5 mg of pilocarpine every 8 hours. Salivary flux was quantified three times: at the beginning of the treatment, at the fourth and at the seventh week. The quantification was realized by the mass difference method. When the first quantification was carried out at the beginning of radiotherapy treatment, no patient had received medication. Comparing both groups we obtained t = 0.525, p = 0.606, so that there was no statistically significant difference in salivary flux. In the fifth week a reduction of salivary flux in both groups was observed, when the groups were compared there was no statistically significant difference between them (t = 0.481, p = 0.636). In the seventh week a significative increment in salivary flux in the study group compared with the control group was observed. For the study group the values were: mean = 0.651 and standard deviation = 0.380, while for the control group the values were: mean = 0.256 and standard deviation = 0.251. By comparing the groups with t-Student test, the results were: t = 2.743, &#961; = 0.013. It is concluded that pilocarpine is an alternative, viable, safe and economic treatment for xerostomy induced by radiotherapy.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Xerostomía]]></kwd>
<kwd lng="es"><![CDATA[pilocarpina]]></kwd>
<kwd lng="en"><![CDATA[Xerostomy]]></kwd>
<kwd lng="en"><![CDATA[pilocarpine]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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