Comportamiento viscoelástico de disoluciones y tabletas hidratadas de hidroxipropilmetil celulosa, carboximetil celulosa sódica y sus mezclas
Viscoelastic behavior of solutions and hydrated tablets of individual hydroxypropylmethylcellulose, sodium carboxymethylcellulose, and their mixtures
M. de L. Garzón1*, A. Tecante2, M. Ramírez–Gilly2 y J. Palacios3
1 Departamento de Sistemas Biológicos. Universidad Autónoma Metropolitana–Xochimilco, Calzada del Hueso 1100, Villa Quietud. Coyoacán, 04960, México. * Autor para la correspondencia. E–mail: lgarzon@correo.xoc.uam.mx Tel/FAX: (55) 54 83 72 68
2 Departamento de Alimentos y Biotecnología, Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, D.F., 04510, México
]]> 3 Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, D.F., 04510, México.
Recibido 1 de Julio 2009
Aceptado 2 de Octubre 2009
Resumen
Las propiedades reológicas de los polímeros hidrofílicos con los cuales se elaboran medicamentos orales sólidos, podrían afectar la cinética de liberación del fármaco una vez que se encuentren en contacto con los fluidos gastrointestinales. La hidroxipropilmetilcelulosa (HPMC) y la carboximetilcelulosa sódica (CMCNa) son ampliamente utilizadas en la elaboración de tabletas, por lo cual se estudiaron sus propiedades viscoelásticas a diferentes pH's, a partir de disoluciones y tabletas hidratadas de los polímeros individuales y de sus mezclas. Se observaron diferencias en el comportamiento viscoelástico entre las disoluciones y las tabletas, el cual fue dependiente del pH y de la proporción de los componentes. A pH 1.3 se observaron las mayores diferencias. En ningún caso se detectó la formación de geles verdaderos.
Palabras clave: celulosa, polímeros hidrofílicos, geles, tabletas, viscoelasticidad.
Abstract
]]> The rheological properties of hydrophilic pharmaceutical polymers used for oral solid dosage forms could have an effect on the kinetics of drug release when they come in contact with gastrointestinal fluids. Hydroxypropylmethylcellulose (HPMC) and sodium carboxymethylcellulose (CMCNa) are common ingredients of pharmaceutical drug tablets. Therefore, the viscoelastic behavior of solutions and hydrated tablets of the individual polymers and their mixtures was studied at different pHs. The viscoelastic behavior of solutions and tablets was different, but it was pH dependent. At pH 1.3 the largest differences were observed. Gelation was not observed in any of the examined samples.Keywords: cellulose, hydrophilic polymers, gels, tablets, viscoelasticity.
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