<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1456</journal-id>
<journal-title><![CDATA[Biotecnia]]></journal-title>
<abbrev-journal-title><![CDATA[Biotecnia]]></abbrev-journal-title>
<issn>1665-1456</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Sonora, División de Ciencias Biológicas y de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-14562024000100184</article-id>
<article-id pub-id-type="doi">10.18633/biotecnia.v26.2378</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Prosthechea karwinskii leaves extract with potential for the treatment of atherothrombosis]]></article-title>
<article-title xml:lang="es"><![CDATA[Extracto de hojas de Prosthechea karwinskii con potencial para el tratamiento de la aterotrombosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barragán Zarate]]></surname>
<given-names><![CDATA[Gabriela Soledad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lagunez Rivera]]></surname>
<given-names><![CDATA[Luicita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Solano]]></surname>
<given-names><![CDATA[Rodolfo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Juárez]]></surname>
<given-names><![CDATA[Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López Pérez]]></surname>
<given-names><![CDATA[Abimael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carranza Álvarez]]></surname>
<given-names><![CDATA[Candy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Politécnico Nacional Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Laboratorio de Extracción y Análisis de Productos Naturales Vegetales]]></institution>
<addr-line><![CDATA[ Oaxaca]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Autónoma de San Luis Potosí Unidad Académica Multidisciplinaria de la Zona Huasteca ]]></institution>
<addr-line><![CDATA[Ciudad Valles San Luis Potosí]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>26</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-14562024000100184&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-14562024000100184&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-14562024000100184&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Prosthechea karwinskii is an orchid endemic to southern Mexico used in traditional medicine. It has anti-inflammatory, antioxidant and cardioprotective activity. Given the relationship between inflammation, oxidative stress, and coagulation in the development of atherothrombosis, the objective of this research was to evaluate the potential of P. karwinskii leaves extract as a possible alternative to reduce the risk of atherothrombosis. The compounds of the extract were identified by UHPLC-ESI-qTOF-MS. The content of total phenols and flavonoids was measured, as well as its antioxidant capacity (DPPH and DCFH-DA essays) and its effect on clotting times. The results showed the presence of phenolic and flavonoid compounds in the extract, as well as their antioxidant capacity. In addition, the extract prolonged clotting times, mainly thrombin, and activated partial thromboplastin times, i.e., it inhibited the intrinsic pathway of hemostasis and the conversion of fibrinogen to fibrin. These results and the background of the extract show its potential as a treatment to reduce atherothrombotic risk, as well as for other diseases whose pathogenesis involves oxidative stress and coagulation.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Prosthechea karwinskii es una orquídea endémica del sureste de México empleada en la medicina tradicional, presenta actividad antiinflamatoria, antioxidante y cardioprotección. Dada la relación que existe entre la inflamación, el estrés oxidativo y la coagulación en el desarrollo de aterotrombosis, el objetivo de esta investigación fue evaluar el potencial del extracto de hojas de P. karwinskii como posible alternativa para disminuir el riesgo de aterotrombosis. Se identificaron los compuestos del extracto por UHPLC-ESI-qTOF-MS, se midió el contenido de fenoles y flavonoides totales, su capacidad antioxidante (ensayos DPPH y DCFH-DA) y su efecto en los tiempos de coagulación. Los resultados mostraron la presencia de compuestos fenólicos y flavonoides en el extracto, así como su capacidad antioxidante. Además, el extracto prolongó los tiempos de coagulación, principalmente los tiempos de trombina y de tromboplastina parcial activada, es decir, inhibió la vía intrínseca de la hemostasia y la conversión del fibrinógeno en fibrina. Estos resultados y los antecedentes del extracto muestran su potencial como tratamiento para reducir el riesgo aterotrombótico, así como para otras enfermedades cuya patogénesis involucre al estrés oxidativo y la coagulación.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[anticoagulant]]></kwd>
<kwd lng="en"><![CDATA[cellular antioxidant]]></kwd>
<kwd lng="en"><![CDATA[reactive oxygen species]]></kwd>
<kwd lng="es"><![CDATA[anticoagulante]]></kwd>
<kwd lng="es"><![CDATA[antioxidante celular]]></kwd>
<kwd lng="es"><![CDATA[especies reactivas del oxígeno]]></kwd>
</kwd-group>
</article-meta>
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