<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1456</journal-id>
<journal-title><![CDATA[Biotecnia]]></journal-title>
<abbrev-journal-title><![CDATA[Biotecnia]]></abbrev-journal-title>
<issn>1665-1456</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Sonora, División de Ciencias Biológicas y de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-14562024000100169</article-id>
<article-id pub-id-type="doi">10.18633/biotecnia.v26.2420</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Renal physiopathologic changes in diabetic Golden-Syrian hamsters ( Mesocricetus auratus) fed with hypercaloric diet]]></article-title>
<article-title xml:lang="es"><![CDATA[Cambios fisiopatológicos renales en hámster sirio-dorado (Mesocricetus auratus) diabéticos alimentados con dieta hipercalórica]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gálvez-Gastélum]]></surname>
<given-names><![CDATA[Francisco Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarez-Rodríguez]]></surname>
<given-names><![CDATA[Bertha Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yañez-Sánchez]]></surname>
<given-names><![CDATA[Irinea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Domínguez-Rosales]]></surname>
<given-names><![CDATA[José Alfredo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-López]]></surname>
<given-names><![CDATA[Citlali Arlae]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palomares-Marín]]></surname>
<given-names><![CDATA[Jaime]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez-Hurtado]]></surname>
<given-names><![CDATA[Itzae Adonai]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salazar Montes]]></surname>
<given-names><![CDATA[Adriana María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vera-Cruz]]></surname>
<given-names><![CDATA[José María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Guadalajara Departamento de Microbiología y Patología ]]></institution>
<addr-line><![CDATA[ Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Guadalajara Centro de investigación en Nanociencias y Nanotecnología Departamento de Ciencias Naturales y Exactas]]></institution>
<addr-line><![CDATA[ Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Guadalajara Instituto de enfermedades crónico-degenerativas Departamento de Biología Molecular y Genómica]]></institution>
<addr-line><![CDATA[Guadalajara Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Guadalajara Departamento de producción animal ]]></institution>
<addr-line><![CDATA[ Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad de Guadalajara Instituto de Nutrigenética y Nutrigenómica Traslacional Departamento de Biología Molecular y Genomica]]></institution>
<addr-line><![CDATA[ Jalisco]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>26</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-14562024000100169&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-14562024000100169&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-14562024000100169&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Background: Diabetic nephropathy is the single major cause of end stage renal failure. The increase of visceral adipose tissue may lead to glomerular hypertrophy and chronic kidney disease. Our objective was to determine renal changes in diabetic Golden-Syrian Hamster (Mesocricetus auratus) supplemented with a hypercaloric diet. Methods: One group of animals (n =10) was fed with a standard diet (SD), and the other group (n =10) was fed with a hypercaloric diet (HCD) for 1 month. Afterwards, both groups were treated with three doses of Streptozotocin. Hyperglycemia was determined throughout 73 d. The animal&#8217;s weight, blood and kidney tissues were obtained for analysis. Results: Diabetic animals fed with HCD diet manifested hyperglycemia (250 - 350 mg/dL) with significant weight loss (40 g), and an important glomerular filtration rate decrement (0.491 mL/min). Regarding renal fibrosis, all animals showed an increase of glomerular, interstitial, and cortical extracellular matrix (36.3, 75.2 and 70.7 %, respectively). Diabetic animals that were SD-fed showed only mild hyperglycemia and slight increase of glomerular, interstitial, and cortical extracellular matrix. A group of animals (n = 5), fed exclusively with HCD, was also included in the study. Conclusions: Our finding suggests that HCD feeding can accelerate the progression of chronic kidney disease in a diabetic condition.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Antecedentes:  La nefropatía diabética es la principal causa de insuficiencia renal terminal. El aumento del tejido adiposo visceral puede provocar hipertrofia glomerular y enfermedad renal crónica. El objetivo es determinar los cambios renales en hámster sirio dorado (Mesocricetus auratus) diabéticos suplementados con una dieta hipercalórica. Métodos: Un grupo de animales (n =10) alimentado con dieta estándar (SD) y otro (n =10) con dieta hipercalórica (HCD) durante 1 mes. Posteriormente, ambos grupos fueron tratados con tres dosis de Estreptozotocina. La hiperglucemia se determinó durante 73 días. Se obtuvo el peso de los animales, sangre y tejido renal. Resultados: Los animales diabéticos alimentados con HCD manifestaron hiperglucemia (250-350 mg/dL) con pérdida de peso significativa (40 g), disminución del filtrado glomerular (0.491 mL/min) y aumento de la matriz extracelular glomerular, intersticial y cortical (36.3, 75.2 y 70.7 %, respectivamente). Los animales diabéticos que fueron alimentados con SD mostraron sólo una hiperglucemia leve y un ligero aumento de la matriz extracelular glomerular, intersticial y cortical. Un grupo de animales (n = 5) alimentados exclusivamente con HCD fue incluido en el estudio. Conclusiones: Nuestro hallazgo sugiere que la alimentación con HCD puede acelerar la progresión de la enfermedad renal crónica en una condición diabética.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Diabetic]]></kwd>
<kwd lng="en"><![CDATA[Nephropathy]]></kwd>
<kwd lng="en"><![CDATA[Hypercaloric diet]]></kwd>
<kwd lng="en"><![CDATA[Histopathologic]]></kwd>
<kwd lng="en"><![CDATA[Fibrosis]]></kwd>
<kwd lng="es"><![CDATA[Diabético]]></kwd>
<kwd lng="es"><![CDATA[Nefropatía]]></kwd>
<kwd lng="es"><![CDATA[Dieta hipercalórica]]></kwd>
<kwd lng="es"><![CDATA[Histopatológico]]></kwd>
<kwd lng="es"><![CDATA[Fibrosis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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