<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1456</journal-id>
<journal-title><![CDATA[Biotecnia]]></journal-title>
<abbrev-journal-title><![CDATA[Biotecnia]]></abbrev-journal-title>
<issn>1665-1456</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Sonora, División de Ciencias Biológicas y de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-14562023000100019</article-id>
<article-id pub-id-type="doi">10.18633/biotecnia.v25i1.1790</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Confiabilidad del hisopado de piel y muestra de orina para detectar fiebre manchada por Rickettsia rickettsii en Sonora usando PCR en punto final en pacientes hospitalizados]]></article-title>
<article-title xml:lang="en"><![CDATA[Cutaneous Swab and Urine Samples Reliability to Detect Rickettsia rickettsii through PCR in hospitalized patients, Sonora]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Cortez]]></surname>
<given-names><![CDATA[Cynthia Yadira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez Hernández]]></surname>
<given-names><![CDATA[Gerardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bolado Martínez]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Candia Plata]]></surname>
<given-names><![CDATA[Maria del Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Medina]]></surname>
<given-names><![CDATA[Miguel Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Sonora Departamento de Medicina y Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Sonora Departamento de Ciencias Químico Biológicas ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Infantil del Estado de Sonora Área de Enseñanza e Investigación ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<volume>25</volume>
<numero>1</numero>
<fpage>140</fpage>
<lpage>146</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-14562023000100019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-14562023000100019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-14562023000100019&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La determinación de anticuerpos IgM e IgG por inmunofluorescencia indirecta es la prueba estándar para confirmar la fiebre manchada por Rickettsia rickettsii (FMRR), aunque tiene limitado valor clínico pues requiere tres semanas para ser confiable. La Reacción en Cadena de la Polimerasa (PCR) es una opción para el diagnóstico en sangre total, pero hay menos certidumbre respecto a su capacidad al usar muestras de orina y tejido. Nos proponemos estimar la confiabilidad de PCR en muestras de hisopado cutáneo y orina en pacientes sospechosos de FMRR, comparándole con resultados de PCR en muestras de sangre total. Se analizaron muestras de 110 pacientes sospechosos de FMRR atendidos en hospitales de Sonora, entre septiembre de 2018 y octubre de 2019. El cálculo de la confiabilidad se realizó mediante el Coeficiente de Kappa (K). Se detectó R. rickettsii en 21 muestras de orina, encontrando una concordancia sustancial (K = 0.607, IC 95 % (0.385, 0.844)); en tanto, 3 hisopados cutáneos resultaron positivos, pero sin significancia estadística (K = 0.417, IC95 % (- 0.338, 1.172)). Nuestros hallazgos sustentan que la PCR en orina es una técnica confiable para confirmar la sospecha clínica de FMRR en pacientes hospitalizados.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Rocky Mountain spotted fever (RMSF) is an infectious disease confirmed through IgM and IgG determination obtained by indirect immunofluorescence, although it has limited clinical value since it requires up to three weeks to be reliable. Polymerase Chain Reaction (PCR) is an alternative for RMSF diagnosis in whole blood, but there is less certainty regarding its certainty when urine and tissue samples are used. This study aimed to estimate the reliability of PCR in skin swab and urine samples obtained from patients with suspected RMSF, comparing it with PCR results from whole blood samples. Samples from 110 suspected RMSF hospitalized patients, between September 2018 and October 2019, were analyzed. Reliability was calculated using the Kappa Coefficient (K). R. rickettsii was detected in 21 urine samples, finding substantial agreement (K = 0.607, 95 % CI (0.385, 0.844)); meanwhile, 3 skin swabs were positive, but without statistical significance (K = 0.417, 95 % CI (- 0.338, 1.172)). Our findings support that urine PCR is a reliable technique to confirm clinical suspicion of RMSF in hospitalized patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Fiebre manchada de las Montañas Rocosas]]></kwd>
<kwd lng="es"><![CDATA[PCR]]></kwd>
<kwd lng="es"><![CDATA[detección temprana de la enfermedad]]></kwd>
<kwd lng="es"><![CDATA[confiabilidad]]></kwd>
<kwd lng="en"><![CDATA[Rocky Mountain spotted fever]]></kwd>
<kwd lng="en"><![CDATA[PCR]]></kwd>
<kwd lng="en"><![CDATA[early detection of disease]]></kwd>
<kwd lng="en"><![CDATA[reliability]]></kwd>
</kwd-group>
</article-meta>
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