<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1146</journal-id>
<journal-title><![CDATA[Boletín médico del Hospital Infantil de México]]></journal-title>
<abbrev-journal-title><![CDATA[Bol. Med. Hosp. Infant. Mex.]]></abbrev-journal-title>
<issn>1665-1146</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-11462021000600652</article-id>
<article-id pub-id-type="doi">10.24875/bmhim.21000035</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Dermatitis granulomatosa neutrofílica en empalizada como presentación inicial de lupus eritematoso sistémico]]></article-title>
<article-title xml:lang="en"><![CDATA[Palisaded neutrophilic granulomatous dermatitis as the initial presentation of systemic lupus erythematosus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Henostroza-Inga]]></surname>
<given-names><![CDATA[Katia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres-Ibérico]]></surname>
<given-names><![CDATA[Rosario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Atamari-Anahui]]></surname>
<given-names><![CDATA[Noé]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lipa-Chancolla]]></surname>
<given-names><![CDATA[Roxana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Salud del Niño-Breña Servicio de Dermatología ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Perú</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad San Ignacio de Loyola  ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Perú</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Salud del Niño-San Borja Servicio de Anatomía Patológica ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Perú</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>78</volume>
<numero>6</numero>
<fpage>652</fpage>
<lpage>656</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-11462021000600652&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-11462021000600652&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-11462021000600652&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La dermatitis granulomatosa neutrofílica en empalizada es una manifestación cutánea poco frecuente en la infancia que se asocia con patologías autoinmunitarias. La patogénesis exacta de esta enfermedad aún se desconoce. Sin embargo, se ha sugerido que el depósito de complejos inmunitarios podría iniciarla.  Caso clínico: Se describe el caso de una paciente de 11 años que presentó lesiones polimórficas en las extremidades asociadas a poliartralgias. Fue diagnosticada de lupus eritematoso sistémico y nefritis lúpica. Por las lesiones en la piel, se realizaron estudios histopatológico e inmunohistoquímico (CD68, CD163, mieloperoxidasa), que dieron como resultado dermatitis granulomatosa neutrofílica en empalizada. Debido al compromiso renal, se administró tratamiento con pulsos de metilprednisolona, además de hidroxicloroquina, micofenolato de mofetilo, antihipertensivos y antiinflamatorios no esteroideos. La respuesta clínica fue favorable durante el seguimiento.  Conclusiones: La dermatitis granulomatosa neutrofílica en empalizada asociada a lupus eritematoso sistémico es inusual. Por ello, es importante su reconocimiento, ya que puede presentarse como manifestación inicial de la enfermedad autoinmunitaria.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Palisaded neutrophilic granulomatous dermatitis is a rare cutaneous manifestation in children associated with autoimmune pathologies. The exact pathogenesis of this disease is still unknown. However, it has been suggested that the deposition of immune complexes could initiate this pathology.  Case report: We describe the case of an 11-year-old female patient who presented with polymorphic lesions in extremities associated with polyarthralgia. She was diagnosed with systemic lupus erythematosus and lupus nephritis. Because of the skin lesions, histopathological and immunohistochemical skin studies (CD68, CD163, myeloperoxidase) were performed, which resulted in palisaded neutrophilic granulomatous dermatitis. Due to renal involvement, treatment was administered with methylprednisolone pulses, hydroxychloroquine, mycophenolate mofetil, antihypertensives, and nonsteroidal anti-inflammatory drugs. The clinical response was favorable during follow-up.  Conclusions: Palisaded neutrophilic granulomatous dermatitis associated with systemic lupus erythematosus is unusual. Therefore, its recognition is important, as it may appear as the initial manifestation of this autoimmune disease.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Dermatitis granulomatosa neutrofílica en empalizada]]></kwd>
<kwd lng="es"><![CDATA[Dermatitis granulomatosa intersticial]]></kwd>
<kwd lng="es"><![CDATA[Lupus eritematoso sistémico]]></kwd>
<kwd lng="es"><![CDATA[Niños]]></kwd>
<kwd lng="en"><![CDATA[Palisaded neutrophilic granulomatous dermatitis]]></kwd>
<kwd lng="en"><![CDATA[Interstitial granulomatous dermatitis]]></kwd>
<kwd lng="en"><![CDATA[Systemic lupus erythematosus]]></kwd>
<kwd lng="en"><![CDATA[Child]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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