<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-9940</journal-id>
<journal-title><![CDATA[Archivos de cardiología de México]]></journal-title>
<abbrev-journal-title><![CDATA[Arch. Cardiol. Méx.]]></abbrev-journal-title>
<issn>1405-9940</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Cardiología Ignacio Chávez]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-99402017000300205</article-id>
<article-id pub-id-type="doi">10.1016/j.acmx.2017.02.003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Uso de micro RNA en el manejo de la insuficiencia cardiaca]]></article-title>
<article-title xml:lang="en"><![CDATA[Use of microRNAs in heart failure management]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arias Sosa]]></surname>
<given-names><![CDATA[Luis Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Pedagógica y Tecnológica de Colombia  ]]></institution>
<addr-line><![CDATA[Tunja ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<volume>87</volume>
<numero>3</numero>
<fpage>205</fpage>
<lpage>224</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-99402017000300205&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-99402017000300205&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-99402017000300205&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La insuficiencia cardiaca (IC) es una enfermedad de alto impacto que afecta en gran medida a todas las poblaciones humanas, por lo que se ha hecho necesario el desarrollo de nuevas estrategias y métodos para manejarla. Entre estas encontramos a los microRNA, pequeños RNA no codificantes que regulan la expresión genética y que aparecen como una importante opción en el diagnóstico, pronóstico y tratamiento de esta patología. Resultados de múltiples investigaciones han establecido miRNA específicos como notorios biomarcadores de la IC, puesto que estos pueden ser aislados en fluidos corporales como la sangre y la cuantificación de sus niveles se puede correlacionar con la presencia, estado o características específicas de la enfermedad. Desde el punto de la terapéutica, por su importante rol en el control de la expresión génica y la homeostasis celular, se ha explorado su uso en la prevención o tratamiento de las características patológicas de la IC. Por ello, en esta revisión se busca mostrar la importancia de la investigación biomédica en el uso de miRNA como método para el manejo de la IC, mostrando la afectación de enfermedad en el mundo, aspectos importantes sobre la biología de los miRNA, así como avances en su uso como biomarcadores y dianas terapéuticas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Heart failure (HF) is a high impact disease that affects all human populations, demanding the development of new strategies and methods to manage this pathology. That&#8217;s why microRNAs, small noncoding RNAs that regulate gene expression, appear as an important option in the diagnosis, prognosis and treatment of this disease. MiRNAs seems to have a future on HF handling, because can be isolated from body fluids such as blood, and changes in its levels can be associated with the presence, stage and specific disease features, which makes them an interesting option as biomarkers. Also, due to the important role of these molecules on regulation of gene expression and cell homeostasis, it has been explored its potential use as a therapeutic method to prevent or treat HF. That is why this review seeks to show the importance of biomedical research involving the use of miRNAs as a method to approach the HF, showing the impact of disease in the world, aspects of miRNAs biology, and their use as biomarkers and as important therapeutic targets.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Arritmias]]></kwd>
<kwd lng="es"><![CDATA[Remodelación cardíaca]]></kwd>
<kwd lng="es"><![CDATA[Insuficiencia cardiaca]]></kwd>
<kwd lng="es"><![CDATA[Micro RNA]]></kwd>
<kwd lng="es"><![CDATA[Regeneración]]></kwd>
<kwd lng="es"><![CDATA[Colombia]]></kwd>
<kwd lng="en"><![CDATA[Arrhythmias]]></kwd>
<kwd lng="en"><![CDATA[Cardiac remodeling]]></kwd>
<kwd lng="en"><![CDATA[Heart failure]]></kwd>
<kwd lng="en"><![CDATA[Micro RNAs]]></kwd>
<kwd lng="en"><![CDATA[Regeneration]]></kwd>
<kwd lng="en"><![CDATA[Colombia]]></kwd>
</kwd-group>
</article-meta>
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