<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-888X</journal-id>
<journal-title><![CDATA[TIP. Revista especializada en ciencias químico-biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[TIP]]></abbrev-journal-title>
<issn>1405-888X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Zaragoza]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-888X2021000100113</article-id>
<article-id pub-id-type="doi">10.22201/fesz.23958723e.2021.359</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Use of 13C-glucose breath test to assess treatment adherence in nutritional intervention trials]]></article-title>
<article-title xml:lang="es"><![CDATA[Uso de la prueba de aliento con 13C-glucosa para evaluar la adherencia al tratamiento en ensayos de intervención nutricional]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Rojas]]></surname>
<given-names><![CDATA[Vanessa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maldonado-Hernández]]></surname>
<given-names><![CDATA[Jorge]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mora-Escobedo]]></surname>
<given-names><![CDATA[Rosalva]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Izquierdo-Montalvo]]></surname>
<given-names><![CDATA[Georgina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Verma]]></surname>
<given-names><![CDATA[Mahendra P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aragón-Aguilar]]></surname>
<given-names><![CDATA[Alfonso]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ángel-Serrato]]></surname>
<given-names><![CDATA[Dominic]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Encarnación-Fernández]]></surname>
<given-names><![CDATA[Jorge Saúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[San Martín-Martínez]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Politécnico Nacional Escuela Nacional de Ciencias Biológicas Departamento de Ingeniería Bioquímica]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Centro Médico Nacional Siglo XXI ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Electricidad y Energías Limpias Gerencia de Geotermia ]]></institution>
<addr-line><![CDATA[Cuernavaca Morelos]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Politécnica de Nochixtlán "Abraham Castellanos"  ]]></institution>
<addr-line><![CDATA[Asunción Nochixtlán Oaxaca]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Politécnico Nacional Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada Laboratorio de Biomateriales y Procesos Químicos]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>24</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-888X2021000100113&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-888X2021000100113&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-888X2021000100113&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective: To validate the use of the 13C-glucose breath test to assess nutritional treatment adherence.  Methods: A pilot study was conducted on eleven adults. A snack made of soybean/corn-starch was enriched with U-13C-glucose. The participants were divided in three groups that consumed the snack in different periods for two weeks (A=14 days, B=10 days and C=6 days). Breath samples were collected daily to analyse the &#948; 13C values with isotope-ratio mass spectrometry.  Results: AUC (area under the curve) median of &#948; 13C values of group A was higher than group C (p = 0.029); differences were found when combining groups, A and B medians, comparing them with group C (p = 0.038). A negative association was found between AUC &#948;13C values and treatment intensity (Spearman rho = -0.708; p = 0.015). A cut-off &#8804; 3.78 identifies subjects with less than 70% accomplishment of the treatment with 100% specificity and 86% sensitivity.  Conclusions: The 13C-glucose breath test suggests a good diagnostic performance to assess treatment adherence.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo: Validar el uso de la prueba de aliento con 13C-glucosa para evaluar la adherencia a un tratamiento nutricional.  Métodos: Se realizó una prueba piloto, con once adultos, que ingirieron una botana compuesta de soya/almidón de maíz y enriquecida con U-13C-glucosa. Los participantes se dividieron en tres grupos de estudio y consumieron la botana en diferentes períodos de tiempo durante dos semanas (A=14 días, B=10 días, C=6 días). Diariamente se colectaron muestras de aliento para analizar los valores de &#948;13C, mediante espectrometría de masas de relaciones isotópicas.  Resultados: La mediana del AUC (área bajo la curva) de los valores de &#948; 13C del grupo A fue mayor comparada con la del grupo C (p = 0.029); por otro lado, se encontraron diferencias significativas al combinar los grupos (medianas A y B) y ser comparados con el grupo C (p = 0.038). Finalmente, se encontró una asociación negativa entre los valores de AUC &#948; 13C y la intensidad del tratamiento (rho de Spearman = -0,708; p = 0,015). Se pudo establecer un punto de corte &#8804; 3,78, para identificar a los sujetos que cumplieron con menos del 70% del tratamiento, con un 100% de especificidad y un 86% de sensibilidad.  Conclusiones: La prueba de aliento con 13C-glucosa, sugiere un buen rendimiento diagnóstico para evaluar la adherencia al tratamiento.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[13C-glucose breath-test]]></kwd>
<kwd lng="en"><![CDATA[nutritional treatment compliance]]></kwd>
<kwd lng="en"><![CDATA[treatment adherence]]></kwd>
<kwd lng="en"><![CDATA[13C]]></kwd>
<kwd lng="en"><![CDATA[soy-based snack]]></kwd>
<kwd lng="es"><![CDATA[prueba de aliento con 13C-glucosa]]></kwd>
<kwd lng="es"><![CDATA[apego a tratamiento nutricional]]></kwd>
<kwd lng="es"><![CDATA[adherencia al tratamiento]]></kwd>
<kwd lng="es"><![CDATA[13C]]></kwd>
<kwd lng="es"><![CDATA[botana a base de soya]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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