<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-888X</journal-id>
<journal-title><![CDATA[TIP. Revista especializada en ciencias químico-biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[TIP]]></abbrev-journal-title>
<issn>1405-888X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Zaragoza]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-888X2009000200075</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Los metales como inhibidores del sistema de reparación del ADN]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Franco]]></surname>
<given-names><![CDATA[Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valverde]]></surname>
<given-names><![CDATA[Mahara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas]]></surname>
<given-names><![CDATA[Emilio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Instituto de Investigaciones Biomédicas Departamento de Medicina Genómica y Toxicología Ambiental]]></institution>
<addr-line><![CDATA[México, D.F. ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2009</year>
</pub-date>
<volume>12</volume>
<numero>2</numero>
<fpage>75</fpage>
<lpage>82</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-888X2009000200075&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-888X2009000200075&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-888X2009000200075&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Los humanos han estado en contacto con los metales desde su aparición en el planeta. De hecho no se puede pensar en la evolución humana sin pensar en el gran papel que han jugado los metales en el desarrollo humano. Algunos metales son esenciales para llevar a cabo procesos celulares, sin embargo, otros son capaces de promover una gran variedad de efectos deletéreos para la salud, incluyendo el cáncer. Las evidencias de que la inhibición de los mecanismos de reparación del ADN, es un importante paso para que se lleve a cabo la carcinogénesis inducida por los metales cobran día a día más importancia, sin embargo, es poco probable que exista un mecanismo de acción común para todos los metales debido a que presentan propiedades químicas diversas. En la presente revisión, se discutirá el papel de los metales en la inhibición de los mecanismos de reparación, poniendo énfasis en algunos mecanismos de acción propuestos como son: la inactivación de enzimas, la unión a componentes celulares, la inducción de daño al ADN, entre otros.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Humans have been in contact with metals almost since the beginning of our existence. In fact, one cannot even think on human evolution without considering the great role played by metals in mankind&#8217;s development. Some metals are essentials for cellular processes; however other metals are less beneficial, owing to their ability to promote a wide variety of deleterious health effects, including cancer. The evidence that inhibition of DNA-repair processes is an important step in metal carcinogenesis is growing; however a uniform mechanism of action for all metals is unlikely given the diverse chemical properties of each metal. In the present review, the impairment of DNA-repair by metals and the different mechanisms of metal DNA repair inhibition, such as, inactivation of enzymes, binding to cellular components, induction of DNA damage, etc, will be discussed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Dedos de zinc]]></kwd>
<kwd lng="es"><![CDATA[metales]]></kwd>
<kwd lng="es"><![CDATA[reparación del ADN]]></kwd>
<kwd lng="en"><![CDATA[Zinc fingers]]></kwd>
<kwd lng="en"><![CDATA[metals]]></kwd>
<kwd lng="en"><![CDATA[DNA repair]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<collab>IARC</collab>
<source><![CDATA[IARC Monographs on the Evaluation of Carcinogenic Risks to Humans]]></source>
<year>1993</year>
<publisher-loc><![CDATA[Lyon ]]></publisher-loc>
<publisher-name><![CDATA[IARC]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Beyersmann]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comutagenicity and inhibition of DNA repair by metal ions in mammalian cells]]></article-title>
<source><![CDATA[Biol Trace Elem Res]]></source>
<year>1989</year>
<volume>21</volume>
<page-range>359-65</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Carcinogenicity of metals compounds: possible role of DNA repair inhibition]]></article-title>
<source><![CDATA[Toxicology Letters]]></source>
<year>1998</year>
<numero>102-103</numero>
<issue>102-103</issue>
<page-range>235-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hayes]]></surname>
<given-names><![CDATA[R.B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The carcinogenicity of metals in humans]]></article-title>
<source><![CDATA[Cancer Causes Control]]></source>
<year>1997</year>
<volume>8</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>371-85</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leonard]]></surname>
<given-names><![CDATA[S.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Bower]]></surname>
<given-names><![CDATA[J.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Shi]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses]]></article-title>
<source><![CDATA[Mol Cell Biochem]]></source>
<year>2004</year>
<volume>255</volume>
<numero>1-2</numero>
<issue>1-2</issue>
<page-range>3-10</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Schwerdtle]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications]]></article-title>
<source><![CDATA[Toxicology Letters]]></source>
<year>2002</year>
<volume>127</volume>
<page-range>47-54</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hoeijmakers]]></surname>
<given-names><![CDATA[Jan H.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Genome maintenance mechanisms for preventing cancer]]></article-title>
<source><![CDATA[Nature]]></source>
<year>2001</year>
<volume>411</volume>
<numero>May 17</numero>
<issue>May 17</issue>
<page-range>366-74</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Friedberg]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<source><![CDATA[DNA repair and Mutagenesis]]></source>
<year>1995</year>
<publisher-name><![CDATA[ASM press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mishina]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Duguid]]></surname>
<given-names><![CDATA[E.M.]]></given-names>
</name>
<name>
<surname><![CDATA[He]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Direct Reversal of DNA Alkylation Damage]]></article-title>
<source><![CDATA[Chem. Rev.]]></source>
<year>2006</year>
<volume>106</volume>
<page-range>215-32</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Scicchitano]]></surname>
<given-names><![CDATA[D.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Pegg]]></surname>
<given-names><![CDATA[A.E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of O6-alkylguanine-DNAalkyltransferase by metals]]></article-title>
<source><![CDATA[Mutat Res]]></source>
<year>1987</year>
<volume>192</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>207-10</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bhattacharyya]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Boulden]]></surname>
<given-names><![CDATA[A.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Foote]]></surname>
<given-names><![CDATA[R.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Mitra]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of polyvalent metal ions on the reactivity of human O6-methylguanine-DNA methyltransferase]]></article-title>
<source><![CDATA[Carcinogenesis]]></source>
<year>1998</year>
<volume>9</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>683-5</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Durham]]></surname>
<given-names><![CDATA[T.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Snow]]></surname>
<given-names><![CDATA[T.E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metal ions and Carcinogenesis]]></article-title>
<source><![CDATA[EXS]]></source>
<year>2006</year>
<numero>96</numero>
<issue>96</issue>
<page-range>97-130</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lindahl]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Wood]]></surname>
<given-names><![CDATA[R.D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quality Control by DNA repair]]></article-title>
<source><![CDATA[Science]]></source>
<year>1999</year>
<volume>286</volume>
<numero>december 3</numero>
<issue>december 3</issue>
<page-range>1897-905</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bjørås]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Erling]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Lars]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The base excision repair pathway]]></article-title>
<source><![CDATA[TIBS]]></source>
<year>1995</year>
<page-range>391-7</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Krokan]]></surname>
<given-names><![CDATA[H.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Standal]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Slupphaug]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[DNA glycosylases in the base excision repair of DNA]]></article-title>
<source><![CDATA[Biochem. J.]]></source>
<year>1997</year>
<volume>325</volume>
<page-range>1-16</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Giaginis]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Gatzidou]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Theocharis]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[DNA repair systems as targets of cadmium toxicity]]></article-title>
<source><![CDATA[Toxicol Appl Pharmacol]]></source>
<year>2006</year>
<volume>213</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>282-90</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hodges]]></surname>
<given-names><![CDATA[N.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Chipman]]></surname>
<given-names><![CDATA[J.K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells]]></article-title>
<source><![CDATA[Carcinogenesis]]></source>
<year>2002</year>
<numero>1</numero>
<issue>1</issue>
<page-range>55-60</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Porter]]></surname>
<given-names><![CDATA[D.W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sensitivity of Escherichia coli (MutT) and human (MTH1) 8-oxo-dGTPases to in vitro inhibition by the carcinogenic metals, nickel(II), copper(II), cobalt(II) and cadmium(II)]]></article-title>
<source><![CDATA[Carcinogenesis]]></source>
<year>1997</year>
<volume>18</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1785-91</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Manning]]></surname>
<given-names><![CDATA[F.C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Induction of internucleosomal DNA fragmentation by carcinogenic chromate: relationship to DNA damage, genotoxicity, and inhibition of macromolecular synthesis]]></article-title>
<source><![CDATA[Environ Health Perspect]]></source>
<year>1994</year>
<volume>102</volume>
<numero>^s3</numero>
<issue>^s3</issue>
<supplement>3</supplement>
<page-range>159-67</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Snow]]></surname>
<given-names><![CDATA[E.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[L.S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chromium(III) bound to DNA templates promotes increased polymerase processivity and decreased fidelity during replication in vitro]]></article-title>
<source><![CDATA[Biochemistry]]></source>
<year>1991</year>
<volume>30</volume>
<numero>47</numero>
<issue>47</issue>
<page-range>11238-45</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms]]></article-title>
<source><![CDATA[Environ Health Perspect]]></source>
<year>2002</year>
<volume>110</volume>
<numero>^s5</numero>
<issue>^s5</issue>
<supplement>5</supplement>
<page-range>797-9</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dally]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Induction and repair inhibition of oxidative DNA damage by nickel(II) and cadmium(II) in mammalian cells]]></article-title>
<source><![CDATA[Carcinogenesis]]></source>
<year>1997</year>
<volume>18</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1021-6</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kale]]></surname>
<given-names><![CDATA[S.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Carmichael]]></surname>
<given-names><![CDATA[M.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Harris]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Roy-Engel]]></surname>
<given-names><![CDATA[A.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The L1 Retrotranspositional Stimulation by Particulate and Soluble Cadmium Exposure is Independent of the Generation of DNA Breaks]]></article-title>
<source><![CDATA[Int J Environ Res Public Health]]></source>
<year>2006</year>
<volume>3</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>121-8</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Blessing]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Kraus]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Heindl]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Bal]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interaction of selenium compounds with zinc finger proteins involved in DNA repair]]></article-title>
<source><![CDATA[Eur. J. Biochem.]]></source>
<year>2004</year>
<volume>271</volume>
<page-range>3190-9</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sirover]]></surname>
<given-names><![CDATA[M.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Loeb]]></surname>
<given-names><![CDATA[L.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metal activation of DNA synthesis]]></article-title>
<source><![CDATA[Biochemical and Biophysical Research Communications]]></source>
<year>1976</year>
<volume>3</volume>
<numero>70</numero>
<issue>70</issue>
<page-range>812-7</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Popenoe]]></surname>
<given-names><![CDATA[E.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Schmaeler]]></surname>
<given-names><![CDATA[M.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interaction of human DNA polymerase â with ions of copper, lead, and cadmium]]></article-title>
<source><![CDATA[Arch Biochem Biophys]]></source>
<year>1979</year>
<volume>1</volume>
<numero>196</numero>
<issue>196</issue>
<page-range>109-20</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McNeill]]></surname>
<given-names><![CDATA[D.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Narayana]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Wong]]></surname>
<given-names><![CDATA[H.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Wilson]]></surname>
<given-names><![CDATA[D.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of Ape1 nuclease activity by lead, iron and cadmium]]></article-title>
<source><![CDATA[Environ Health Perspect]]></source>
<year>2004</year>
<volume>112</volume>
<page-range>799-804</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Guliaev]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Hang]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metal inhibition of human Nmethylpurine-DNA glycosylase activity in base excision repair]]></article-title>
<source><![CDATA[Toxicology Letters]]></source>
<year>2006</year>
<volume>166</volume>
<page-range>237-47</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lynn]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Lai]]></surname>
<given-names><![CDATA[H.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Gurr]]></surname>
<given-names><![CDATA[J.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Jan]]></surname>
<given-names><![CDATA[K.Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Arsenite retards DNA break rejoining by inhibiting DNA ligation]]></article-title>
<source><![CDATA[Mutagenesis]]></source>
<year>1997</year>
<volume>12</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>353-8</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Su]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Snow]]></surname>
<given-names><![CDATA[E.T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Arsenic toxicity is enzyme specific and its affects on ligation are not caused by the direct inhibition of DNA repair enzymes]]></article-title>
<source><![CDATA[Mutat Res]]></source>
<year>1998</year>
<volume>408</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>203-18</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Walter]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADPribosyl)ation in cultured human cells]]></article-title>
<source><![CDATA[Dna Repair]]></source>
<year>2006</year>
</nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gillet]]></surname>
<given-names><![CDATA[L.C.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Schärer]]></surname>
<given-names><![CDATA[O.D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair]]></article-title>
<source><![CDATA[Chem. Rev.]]></source>
<year>2006</year>
<volume>106</volume>
<page-range>253-76</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Calsou]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Frit]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Bozzato]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Salles]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Negative interference of metal (II) ions with nucleotide excision repair in human cell-free extracts]]></article-title>
<source><![CDATA[Carcinogenesis]]></source>
<year>1996</year>
<volume>7</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>2779-82</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Snyder]]></surname>
<given-names><![CDATA[R.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Davis]]></surname>
<given-names><![CDATA[G.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Lachmann]]></surname>
<given-names><![CDATA[P.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition by metals of X-ray and ultraviolet-induced DNA repair in human cells]]></article-title>
<source><![CDATA[Biol Trace Elem Res]]></source>
<year>1989</year>
<volume>21</volume>
<page-range>389-98</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Asmuss]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Mullenders]]></surname>
<given-names><![CDATA[L.H.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Eker]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Differential effects of toxic metal compounds on the activities of Fpg and XPA, two zinc finger proteins involved in DNA repair]]></article-title>
<source><![CDATA[Carcinogenesis]]></source>
<year>2000</year>
<volume>21</volume>
<page-range>2097-104</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kopera]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Schwerdtle]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Bal]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Co(II) and Cd(II) Substitute for Zn(II) in the Zinc Finger Derived from the DNA Repair Protein XPA, Demonstrating a Variety of Potential Mechanisms of Toxicity]]></article-title>
<source><![CDATA[Chem. Res. Toxicol.]]></source>
<year>2004</year>
<volume>17</volume>
<page-range>1452-8</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Witkiewicz-Kucharczyk]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Bal]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis]]></article-title>
<source><![CDATA[Toxicology Letters]]></source>
<year>2006</year>
<volume>162</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>29-42</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hossain]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Huq]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Studies on the interaction between Ag(+) and DNA]]></article-title>
<source><![CDATA[J Inorg Biochem]]></source>
<year>2002</year>
<volume>91</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>398-404</page-range></nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hossain]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Huq]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Studies on the interaction between Cd(2+) ions and DNA]]></article-title>
<source><![CDATA[J Inorg Biochem]]></source>
<year>2002</year>
<volume>90</volume>
<numero>3-4</numero>
<issue>3-4</issue>
<page-range>85-96</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>40</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Blessing]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Schwerdtle]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Walter]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Modulation of DNA repair processes by arsenic and selenium compounds]]></article-title>
<source><![CDATA[Toxicology]]></source>
<year>2003</year>
<volume>193</volume>
<page-range>161-9</page-range></nlm-citation>
</ref>
<ref id="B41">
<label>41</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interaction of arsenic (III) with nucleotide excision repair in UV-irradiated human fibroblasts]]></article-title>
<source><![CDATA[Carcinogenesis]]></source>
<year>1997</year>
<volume>18</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>399-405</page-range></nlm-citation>
</ref>
<ref id="B42">
<label>42</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartmann]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Speit]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of arsenic and cadmium on the persistence of mutagen-induced DNA lesions in human cells]]></article-title>
<source><![CDATA[Environ Mol Mutagen]]></source>
<year>1996</year>
<volume>27</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>98-104</page-range></nlm-citation>
</ref>
<ref id="B43">
<label>43</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Kruger]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Beyersmann]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanisms in nickel genotoxicity: the significance of interactions with DNA repair]]></article-title>
<source><![CDATA[Toxicol Lett]]></source>
<year>1994</year>
<volume>72</volume>
<numero>1-3</numero>
<issue>1-3</issue>
<page-range>353-8</page-range></nlm-citation>
</ref>
<ref id="B44">
<label>44</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kasten]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
<name>
<surname><![CDATA[Mullenders]]></surname>
<given-names><![CDATA[L.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cobalt(II) inhibits the incision and the polymerization step of nucleotide excision repair in human fibroblasts]]></article-title>
<source><![CDATA[Mutat Res]]></source>
<year>1997</year>
<volume>383</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>81-9</page-range></nlm-citation>
</ref>
<ref id="B45">
<label>45</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bal]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Schwerdtle]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanism of Nickel Assault on the Zinc Finger of DNA Repair Protein XPA]]></article-title>
<source><![CDATA[Chem. Res. Toxicol.]]></source>
<year>2003</year>
<volume>16</volume>
<page-range>242-8</page-range></nlm-citation>
</ref>
<ref id="B46">
<label>46</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartmann]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Disturbance of DNA damage recognition after UV-irradiation by nickel(II) and cadmium(II) in mammalian cells]]></article-title>
<source><![CDATA[Carcinogenesis]]></source>
<year>1998</year>
<volume>19</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>617-21</page-range></nlm-citation>
</ref>
<ref id="B47">
<label>47</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hartwig]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Schlepegrell]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Dally]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Hartmann]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interaction of carcinogenic metal compounds with deoxyribonucleic acid repair processes]]></article-title>
<source><![CDATA[Ann Clin Lab Sci]]></source>
<year>1996</year>
<volume>26</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>31-8</page-range></nlm-citation>
</ref>
<ref id="B48">
<label>48</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Buermeyer]]></surname>
<given-names><![CDATA[A.B.]]></given-names>
</name>
<name>
<surname><![CDATA[Deschenes]]></surname>
<given-names><![CDATA[S.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Baker Sean]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Liskay]]></surname>
<given-names><![CDATA[R.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mammalian DNA mismatch repair]]></article-title>
<source><![CDATA[Annu. Rev. Genet.]]></source>
<year>1999</year>
<volume>33</volume>
<page-range>533-64</page-range></nlm-citation>
</ref>
<ref id="B49">
<label>49</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jun]]></surname>
<given-names><![CDATA[S.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[G.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Ban]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[DNA mismatch repair system: Classical and fresh roles]]></article-title>
<source><![CDATA[FEBS Journal]]></source>
<year>2006</year>
<volume>273</volume>
<page-range>1609-19</page-range></nlm-citation>
</ref>
<ref id="B50">
<label>50</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lindahl]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[DNA surveillance defect in cancer cells]]></article-title>
<source><![CDATA[Current Biology]]></source>
<year>1994</year>
<volume>4</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B51">
<label>51</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Banerjee]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Flores-Rozas]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2-MSH6 complex]]></article-title>
<source><![CDATA[Nucleic Acids Research]]></source>
<year>2005</year>
<volume>4</volume>
<numero>33</numero>
<issue>33</issue>
<page-range>1410-9</page-range></nlm-citation>
</ref>
<ref id="B52">
<label>52</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[Y.H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cadmium is a mutagen that acts by inhibiting mismatch repair]]></article-title>
<source><![CDATA[Nat Genet]]></source>
<year>2003</year>
<volume>34</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>326-9</page-range></nlm-citation>
</ref>
<ref id="B53">
<label>53</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Clark]]></surname>
<given-names><![CDATA[A.B.]]></given-names>
</name>
<name>
<surname><![CDATA[Kunkel]]></surname>
<given-names><![CDATA[T.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cadmium Inhibits the Functions of Eukaryotic MutS Complexes]]></article-title>
<source><![CDATA[The Journal of Biological Chemistry]]></source>
<year>2004</year>
<volume>52</volume>
<numero>279</numero>
<issue>279</issue>
<page-range>53903-6</page-range></nlm-citation>
</ref>
<ref id="B54">
<label>54</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Weber]]></surname>
<given-names><![CDATA[T.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Widger]]></surname>
<given-names><![CDATA[W.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Kohn]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metal-1,4-dithio-2,3-dihydroxybutane chelates: novel inhibitors of the Rho transcription termination factor]]></article-title>
<source><![CDATA[Biochemistry]]></source>
<year>2003</year>
<volume>42</volume>
<numero>30</numero>
<issue>30</issue>
<page-range>9121-6</page-range></nlm-citation>
</ref>
<ref id="B55">
<label>55</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[A.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Singleton]]></surname>
<given-names><![CDATA[S.F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of the Escherichia coli RecA protein: zinc(II), copper(II) and mercury(II) trap RecA as inactive aggregates]]></article-title>
<source><![CDATA[Journal of Inorganic Biochemistry]]></source>
<year>2004</year>
<volume>98</volume>
<page-range>1981-6</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
