<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412022000100008</article-id>
<article-id pub-id-type="doi">10.24245/gom.v90i1.5521</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Embarazo con betatalasemia menor y aloanticuerpo irregular de baja frecuencia. Reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Pregnancy with beta-thalassemia minor and development of low-frequency irregular alloantibody. Report of a case.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soni-Trinidad,]]></surname>
<given-names><![CDATA[Clementina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vázquez-García,]]></surname>
<given-names><![CDATA[Rubén Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soni-Gallardo,]]></surname>
<given-names><![CDATA[Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Infante,]]></surname>
<given-names><![CDATA[Lucio Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velasco-Cárdenas,]]></surname>
<given-names><![CDATA[Daniela Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sosa-González]]></surname>
<given-names><![CDATA[Celia Karina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Regional de Poza Rica  ]]></institution>
<addr-line><![CDATA[ Veracruz]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Regional de Poza Rica  ]]></institution>
<addr-line><![CDATA[ Veracruz]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Banco de Sangre Soni  ]]></institution>
<addr-line><![CDATA[Tuxpan Veracruz]]></addr-line>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Veracruzana  ]]></institution>
<addr-line><![CDATA[Poza Rica Veracruz]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>90</volume>
<numero>1</numero>
<fpage>90</fpage>
<lpage>95</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412022000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412022000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412022000100008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES: Alrededor de 7% de las mujeres embarazadas resulta con algún tipo de hemoglobinopatía, como la betatalasemia, que corresponde a una alteración de las cadenas beta de la molécula de hemoglobina. El tratamiento de estas pacientes es con múltiples trasfusiones sanguíneas, con el riesgo de aloinmunización.  CASO CLÍNICO:  Paciente de 29 años, con diagnóstico de betatalasemia menor atendida en el servicio de Ginecología y Obstetricia en su primer embarazo, con síndrome anémico severo recurrente. Se le trasfundieron 7 paquetes globulares, causa del aloanticuerpo irregular de baja frecuencia anti-E. El embarazo finalizó a las 39 semanas por cesárea, con un recién nacido masculino vivo de 3550 g, Apgar 9-9, sin complicaciones. A los 35 años tuvo el segundo embarazo que durante su evolución requirió la trasfusión de sangre fenotipada con nueve concentrados eritrocitarios. El embarazo finalizó por cesárea a las 38 semanas, con nacimiento de una niña de 3220 g, Apgar 8-9, sin riesgos ni complicaciones para la madre y su hija.  CONCLUSIÓN: La prevención de la aloinmunización en la embarazada con betatalasemia menor consiste en establecer el fenotipo de los glóbulos rojos para conocer otros sistemas distintos a los tradicionales AB0 o Rh, para evitar reacciones de sensibilización y producción de aloanticuerpos que, de atravesar la barrera placentaria, podrían causar una respuesta inmunitaria en el feto debido a incompatibilidad materno-fetal.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND: About 7% of pregnant women have some type of hemoglobinopathy including beta-thalassemia which corresponds to an alteration of the beta chains of the hemoglobin molecule. The treatment of these patients is with multiple blood transfusions, with the risk of alloimmunization.  CLINICAL CASE: 29-year-old patient with a diagnosis of beta-thalassemia minor seen in the Gynecology and Obstetrics Department in her first pregnancy, with recurrent severe anemic syndrome. She was transfused 7 globular packets, cause of irregular low-frequency anti-E alloantibody. The pregnancy was terminated at 39 weeks by cesarean section, with a live male newborn of 3550 g, Apgar 9-9, without complications. At 35 years of age, she had the second pregnancy which during its evolution required the transfusion of phenotyped blood with nine erythrocyte concentrates. The pregnancy was terminated by cesarean section at 38 weeks, with birth of a girl of 3220 g, Apgar 8-9, without risks or complications for the mother and her daughter.  CONCLUSION: The prevention of alloimmunization in the treatment of pregnant women with beta-thalassemia minor consists of establishing the phenotype of the red blood cells to determine systems other than the traditional AB0 or Rh, to avoid sensitization reactions and production of alloantibodies which, if they cross the placental barrier, could cause an immune response in the fetus due to maternal-fetal incompatibility.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Embarazo]]></kwd>
<kwd lng="es"><![CDATA[betatalasemia]]></kwd>
<kwd lng="es"><![CDATA[hemoglobinopatía]]></kwd>
<kwd lng="es"><![CDATA[transfusión sanguínea]]></kwd>
<kwd lng="es"><![CDATA[isoanticuerpos]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy]]></kwd>
<kwd lng="en"><![CDATA[Beta-thalassemia]]></kwd>
<kwd lng="en"><![CDATA[Hemoglobinopathy]]></kwd>
<kwd lng="en"><![CDATA[Hemoglobin]]></kwd>
<kwd lng="en"><![CDATA[Blood transfusion]]></kwd>
<kwd lng="en"><![CDATA[Isoantibodies]]></kwd>
</kwd-group>
</article-meta>
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