<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412021001000760</article-id>
<article-id pub-id-type="doi">10.24245/gom.v89i10.5664</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Desenlaces perinatales, en un centro de tercer nivel de México de pacientes con colestasis intrahepática del embarazo]]></article-title>
<article-title xml:lang="en"><![CDATA[Perinatal outcomes of patients with intrahepatic cholestasis of pregnancy in a third level center in Mexico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ibargüengoitia-Ochoa]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Romero]]></surname>
<given-names><![CDATA[Carmen Selene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sepúlveda-Rivera]]></surname>
<given-names><![CDATA[Cintia María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lira-Plascencia]]></surname>
<given-names><![CDATA[Josefina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gallardo-Gómez]]></surname>
<given-names><![CDATA[Fabiola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Perinatología Isidro Espinosa de los Reyes  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Perinatología Isidro Espinosa de los Reyes  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Perinatología Isidro Espinosa de los Reyes  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Nacional de Perinatología Isidro Espinosa de los Reyes  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Nacional de Perinatología Isidro Espinosa de los Reyes  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>89</volume>
<numero>10</numero>
<fpage>760</fpage>
<lpage>769</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412021001000760&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412021001000760&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412021001000760&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  OBJETIVO: Describir la atención, tratamiento, desenlaces perinatales y complicaciones asociadas con la colestasis intrahepática del embarazo.  MATERIALES Y MÉTODOS: Estudio de serie de casos, retrospectivo y observacional de pacientes embarazadas, con diagnóstico de colestasis intrahepática atendidas en el Instituto Nacional de Perinatología entre los meses de enero de 2016 a diciembre de 2020. Se evaluaron las características obstétricas, los datos demográficos, clínicos, bioquímicos y de tratamiento, la finalización del embarazo y los desenlaces perinatales.  RESULTADOS: Se analizaron 67 casos de colestasis intrahepática que arrojaron una incidencia de 0.57%. La edad promedio de las pacientes fue 29.0 ± 6.8 años, 30 de 67 eran primigestas, 12 tuvieron el antecedente de colestasis intrahepática en el embarazo previo y 7 de óbito. El inicio de la enfermedad fue en el tercer trimestre en 41 de 67 pacientes. En los estudios de bioquímica 32 de 67 tuvieron valores de ácidos biliares entre 10 y 39 &#956;M/L; 12 de las 67: 40-99 &#956;M/L y 23 más de 100 (&#956;M/L). Se administró tratamiento con ácido ursodesoxicólico a 63 de 67 y ante la falta de respuesta se agregó rifampicina. El promedio de semanas de gestación fue 35.6 ± 2.0 semanas con peso promedio de 2397 ± 572 g. Se encontró líquido amniótico con meconio en 10 neonatos y restricción del crecimiento en 20 de 67; se registraron 2 óbitos.  CONCLUSIONES: Este es el primer estudio efectuado en México que describe la incidencia de la enfermedad y se utiliza la determinación de los ácidos biliares para establecer el diagnóstico. Los desenlaces perinatales coinciden con lo reportado en la bibliografía.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  OBJECTIVE: To describe the care, treatment, perinatal outcomes and complications associated with intrahepatic cholestasis of pregnancy.  MATERIALS AND METHODS:  A retrospective and observational case series study of pregnant patients with a diagnosis of intrahepatic cholestasis seen at the National Institute of Perinatology between January 2016 and December 2020. Obstetric characteristics, demographic, clinical, biochemical and treatment data, pregnancy termination and perinatal outcomes were evaluated.  RESULTS:  Sixty-seven cases of intrahepatic cholestasis were analyzed, yielding an incidence of 0.57%. The mean age of the patients was 29.0 ± 6.8 years, 30 of 67 were primigravidases, 12 had a history of intrahepatic cholestasis in the previous pregnancy and 7 had an abortion. The onset of the disease was in the third trimester in 41 of 67 patients. In biochemistry studies 32 of 67 had bile acid values between 10 and 39 &#956;M/L; 12 of 67: 40-99 &#956;M/L and 23 more than 100 (&#956;M/L). Treatment with ursodeoxycholic acid was administered to 63 of 67 and rifampicin to 4 patients. The mean number of weeks of gestation was 35.6 ± 2.0 weeks with a mean weight of 2397 ± 572 g. Amniotic fluid with meconium was found in 10 neonates and growth restriction in 20 of 67; there were 2 recorded abortions.  CONCLUSIONS:  This is the first study carried out in Mexico in which the incidence of the disease is described, and the determination of bile acids is used to establish the diagnosis. Perinatal outcomes coincide with those reported in the literature.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Colestasis intrahepática]]></kwd>
<kwd lng="es"><![CDATA[embarazo]]></kwd>
<kwd lng="es"><![CDATA[perinatal]]></kwd>
<kwd lng="es"><![CDATA[tercer trimestre]]></kwd>
<kwd lng="es"><![CDATA[ácido ursodesoxicólico]]></kwd>
<kwd lng="es"><![CDATA[rifampicina]]></kwd>
<kwd lng="es"><![CDATA[líquido amniótico]]></kwd>
<kwd lng="es"><![CDATA[meconio]]></kwd>
<kwd lng="en"><![CDATA[Intrahepatic cholestasis]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy]]></kwd>
<kwd lng="en"><![CDATA[Perinatal]]></kwd>
<kwd lng="en"><![CDATA[Third trimester]]></kwd>
<kwd lng="en"><![CDATA[Ursodeoxycholic acid]]></kwd>
<kwd lng="en"><![CDATA[Rifampicin]]></kwd>
<kwd lng="en"><![CDATA[Amniotic fluid]]></kwd>
<kwd lng="en"><![CDATA[Meconium]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guarino]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Cossiga]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Morisco]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The interpretation of liver function tests in pregnancy]]></article-title>
<source><![CDATA[Best Pract Res Clin Gastroenterol]]></source>
<year>2020</year>
<page-range>44-5</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mikolasevic]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Filipec K]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Jakopcic]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Liver disease during pregnancy: a challenging clinical issue]]></article-title>
<source><![CDATA[Med Sci Monit]]></source>
<year>2018</year>
<volume>24</volume>
<page-range>4080-90</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Diken]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Usta]]></surname>
<given-names><![CDATA[I M]]></given-names>
</name>
<name>
<surname><![CDATA[Nassar]]></surname>
<given-names><![CDATA[A. H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A clinical approach to intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Am J Perinatol]]></source>
<year>2014</year>
<volume>31</volume>
<page-range>1-8</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Piechota]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Jelski]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intrahepatic cholestasis of pregnancy: a review of the literature]]></article-title>
<source><![CDATA[J Clin Med]]></source>
<year>2020</year>
<volume>9</volume>
<page-range>1361-7</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brouwers]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Koster]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
<name>
<surname><![CDATA[Page]]></surname>
<given-names><![CDATA[CGC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile acid levels]]></article-title>
<source><![CDATA[Am J Obstet Gynecol]]></source>
<year>2015</year>
<volume>212</volume>
<page-range>100.e1-7</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marschall]]></surname>
<given-names><![CDATA[H U.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Management of intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Expert Rev Gastroenterol Hepatol]]></source>
<year>2015</year>
<volume>9</volume>
<page-range>1273-9</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ozkan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ceylan]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Ozkan O]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Review of a challenging clinical issue: intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[World J Gastroenterol]]></source>
<year>2015</year>
<volume>21</volume>
<page-range>7134-41</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kawakita]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Parikh]]></surname>
<given-names><![CDATA[L I]]></given-names>
</name>
<name>
<surname><![CDATA[Ramsey]]></surname>
<given-names><![CDATA[P S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Predictors of adverse neonatal outcomes in intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Am J Obstet Gynecol]]></source>
<year>2015</year>
<volume>213</volume>
<numero>570</numero>
<issue>570</issue>
<page-range>e1-8</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[M. C]]></given-names>
</name>
<name>
<surname><![CDATA[Ribalta]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalence of intrahepatic cholestasis of pregnancy in Chile]]></article-title>
<source><![CDATA[Ann Inter Med]]></source>
<year>1978</year>
<volume>88</volume>
<page-range>487-93</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Deepak]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[James]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Quaglia]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Liver disease in pregnancy]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2010</year>
<volume>375</volume>
<page-range>594-605</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[B R]]></given-names>
</name>
<name>
<surname><![CDATA[Mortara]]></surname>
<given-names><![CDATA[G A S]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[U A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Colestasis intra-hepática del embarazo: reporte de un caso y revisión de la bibliografía]]></article-title>
<source><![CDATA[Ginec Obstet Méx]]></source>
<year>2013</year>
<volume>81</volume>
<page-range>652-7</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gallardo]]></surname>
<given-names><![CDATA[G J M]]></given-names>
</name>
<name>
<surname><![CDATA[Lemionet]]></surname>
<given-names><![CDATA[E D]]></given-names>
</name>
<name>
<surname><![CDATA[Acevedo]]></surname>
<given-names><![CDATA[G S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Resultados perinatales adversos en colestasis intra-hepática del embarazo]]></article-title>
<source><![CDATA[Perinatol Reprod Hum]]></source>
<year>2018</year>
<volume>32</volume>
<page-range>131-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marschall]]></surname>
<given-names><![CDATA[H U]]></given-names>
</name>
<name>
<surname><![CDATA[Wilkstorm]]></surname>
<given-names><![CDATA[S E]]></given-names>
</name>
<name>
<surname><![CDATA[Ludvigsson J]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intrahepatic cholestasis of pregnancy and associated hepatobiliary disease: a population-based cohort study]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>2013</year>
<volume>58</volume>
<page-range>1385-91</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Geenes]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Chappell]]></surname>
<given-names><![CDATA[L C]]></given-names>
</name>
<name>
<surname><![CDATA[Seed]]></surname>
<given-names><![CDATA[P T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study]]></article-title>
<source><![CDATA[Hepatogy]]></source>
<year>2014</year>
<volume>59</volume>
<page-range>1482-91</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ibrahim]]></surname>
<given-names><![CDATA[S H]]></given-names>
</name>
<name>
<surname><![CDATA[Jonas]]></surname>
<given-names><![CDATA[M M]]></given-names>
</name>
<name>
<surname><![CDATA[Taylor]]></surname>
<given-names><![CDATA[S A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Liver diseases in the perinatal period: interactions between mother and infant]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>2020</year>
<volume>71</volume>
<page-range>1474-85</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Williamson]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Geenes]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Obstet Gynecol]]></source>
<year>2014</year>
<volume>124</volume>
<page-range>120-33</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heikkinen]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum bile acids in the early diagnosis of intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Obstet Gyneco]]></source>
<year>1983</year>
<volume>61</volume>
<page-range>581-7</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Prati]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Taioli]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Zanella]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Updated definitions of heatlhy ranges of serum alanine aminotransferase levels]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>2002</year>
<volume>137</volume>
<page-range>1-10</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Katarey]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Westbrook]]></surname>
<given-names><![CDATA[R H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pregnancy-specific liver diseases]]></article-title>
<source><![CDATA[Best Pract Res Clin Obstet Gynaecol]]></source>
<year>2020</year>
<volume>68</volume>
<page-range>12-22</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Biccoca]]></surname>
<given-names><![CDATA[M J]]></given-names>
</name>
<name>
<surname><![CDATA[Sperling]]></surname>
<given-names><![CDATA[J D]]></given-names>
</name>
<name>
<surname><![CDATA[Cauhan]]></surname>
<given-names><![CDATA[S P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intrahepatic cholestasis of pregnancy: review of six national and regional guidelines]]></article-title>
<source><![CDATA[Eur J Obstet Gynecol Reprod Biol]]></source>
<year>2018</year>
<volume>231</volume>
<page-range>180-7</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Pan]]></surname>
<given-names><![CDATA[S L]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[L P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Risk factors for adverse fetal outcomes among women with early versus late-onset intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Int J Gynaecol Obstet]]></source>
<year>2015</year>
<volume>128</volume>
<page-range>236-40</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ovadia]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Seed]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Sklavaunes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analysis]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2019</year>
<volume>393</volume>
<page-range>899-909</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Patel]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pinheiro]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Felix J]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A case-control review of placentas from patients with intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Fetal Pediatr Pathol]]></source>
<year>2014</year>
<volume>33</volume>
<page-range>210-5</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Herrera]]></surname>
<given-names><![CDATA[C A]]></given-names>
</name>
<name>
<surname><![CDATA[Manuck]]></surname>
<given-names><![CDATA[T A]]></given-names>
</name>
<name>
<surname><![CDATA[Stoddard]]></surname>
<given-names><![CDATA[G J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Perinatal outcomes associated with intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[J Matern Fetal Neonatal Med]]></source>
<year>2018</year>
<volume>31</volume>
<page-range>1913-20</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ekiz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kaya]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Eftal]]></surname>
<given-names><![CDATA[A M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Alanine aminotransferase as a predictor of adverse perinatal outcome in women with intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Pak J Med Sci]]></source>
<year>2016</year>
<volume>32</volume>
<page-range>418-22</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Y H]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[Y Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of intrahepatic cholestasis of pregnancy on neonatal birth weight: a meta-analysis]]></article-title>
<source><![CDATA[J Clin Res Pediatr Endocrinol]]></source>
<year>2018</year>
<volume>10</volume>
<page-range>38-43</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Palma]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Ribalta]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of ursodesoxicolic acid in patients with intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Hepatology]]></source>
<year>1992</year>
<volume>15</volume>
<page-range>1043-7</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bacq]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Sentilhes]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[H B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efficacy of ursodesoxicolic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis]]></article-title>
<source><![CDATA[Gastroenterology]]></source>
<year>2012</year>
<volume>143</volume>
<page-range>1492-501</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Walker]]></surname>
<given-names><![CDATA[K F]]></given-names>
</name>
<name>
<surname><![CDATA[Chappell]]></surname>
<given-names><![CDATA[L C]]></given-names>
</name>
<name>
<surname><![CDATA[Hague]]></surname>
<given-names><![CDATA[W M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pharmacological interventions for treating intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2020</year>
<volume>7</volume>
</nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Geenes]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Chambers]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Khuruma]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Eur J Obstet Gynecol Reprod Biol]]></source>
<year>2015</year>
<volume>189</volume>
<page-range>59-63</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wilkstrom S]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Marschall H]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Ludvigsson J]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study]]></article-title>
<source><![CDATA[BJOG]]></source>
<year>2013</year>
<volume>120</volume>
<page-range>717-23</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arafa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Dong J]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association between intrahepatic cholestasis of pregnancy and risk of gestational diabetes and preeclampsia: a systematic review and meta-analysis]]></article-title>
<source><![CDATA[Hypertens Pregnancy]]></source>
<year>2020</year>
<volume>39</volume>
<page-range>354-60</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Palmer K]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Xiaohua]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Mol B]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Management of intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2019</year>
</nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<collab>Medically indicated late-preterm and early-term deliveries</collab>
<article-title xml:lang=""><![CDATA[ACOG Committee Opinion No. 764. American Collegue Obstetrics and Gynecology]]></article-title>
<source><![CDATA[Obstet Gynecol]]></source>
<year>2019</year>
<volume>133</volume>
<page-range>e151-5</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[H L]]></given-names>
</name>
<name>
<surname><![CDATA[Greenberg]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Metz]]></surname>
<given-names><![CDATA[ID]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Society of Maternal-Fetal Medicine Series # 53. Intrahepatic Cholestasis of Pregnancy]]></article-title>
<source><![CDATA[Am J Obstet Gynecol]]></source>
<year>2021</year>
<volume>224</volume>
<page-range>B2-9</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wilkstrom]]></surname>
<given-names><![CDATA[S E A]]></given-names>
</name>
<name>
<surname><![CDATA[Stephansson]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Thruresson]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intrahepatic cholestasis of pregnancy and cancer, immune-mediated and cardiovascular diseases: a population-based cohort intrahepatic cholestasis study]]></article-title>
<source><![CDATA[J Hepatol]]></source>
<year>2015</year>
<volume>63</volume>
<page-range>456-61</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Floreani]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Garvasi M]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[New insights on intrahepatic cholestasis of pregnancy]]></article-title>
<source><![CDATA[Clin Liv Dis]]></source>
<year>2016</year>
<volume>20</volume>
<page-range>177-89</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carballo-Núñez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Resultados perinatales en pacientes con colestasis del embarazo]]></article-title>
<source><![CDATA[Ginecol Obstet Mex]]></source>
<year>2015</year>
<volume>83</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>776-84</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
