<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412019000500324</article-id>
<article-id pub-id-type="doi">10.24245/gom.v87i5.2811</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tratamiento del cáncer de mama en la mujer embarazada: caso clínico]]></article-title>
<article-title xml:lang="en"><![CDATA[Treatment of breast cancer in pregnant women: clinical case]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montaño-Serrano]]></surname>
<given-names><![CDATA[María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojo-Novo]]></surname>
<given-names><![CDATA[Sara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Albalat-Fernández]]></surname>
<given-names><![CDATA[Rosa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Novo-Cabrera]]></surname>
<given-names><![CDATA[Juan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calle-Marcos]]></surname>
<given-names><![CDATA[Manolo La]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Virgen Macarena de Sevilla Unidad de Gestión Clínica de Obstetricia y Ginecología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<volume>87</volume>
<numero>5</numero>
<fpage>324</fpage>
<lpage>333</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412019000500324&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412019000500324&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412019000500324&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES: El cáncer de mama es la principal neoplasia diagnosticada durante el embarazo y posparto. La incidencia durante el embarazo varía de 0.2-2.6%. El tratamiento implica un reto para los sistemas de salud porque debe valorarse y salvaguardarse el bienestar de la madre y su hijo.  CASO CLÍNICO:  Paciente de 26 años, que acudió a consulta por mastalgia derecha, con crecimiento rápido a partir del inicio del embarazo. Durante la exploración mamaria se evidenció una tumoración de consistencia dura, de 8 cm, que ocupaba ambos cuadrantes superiores de la mama derecha, con enrojecimiento de la piel. La ecografía reportó una tumoración sólido-quística heterogénea, de 8 x 5 cm, sin ganglios patológicos axilares. El estudio anatomopatológico de la biopsia reportó un carcinoma infiltrante, con inmunofenotipo triple negativo (inmunorreactividad negativa para receptores de estrógenos y progesterona, y Her-2 con índice de proliferación Ki67 de 80%), con lo que se confirmó el diagnóstico de cáncer de mama localmente avanzado en el segundo trimestre del embarazo. Después de la administración de tres ciclos de quimioterapia neoadyuvante con antraciclinas (doxorrubicina y ciclofosfamida) cada tres semanas, se indicó la finalización del embarazo mediante la inducción del parto en la semana 36 + 6. Nació un varón de 2800 g, con Apgar 9-10-10. La madre y su hijo evolucionaron satisfactoriamente, por lo que recibieron el alta hospitalaria 4 días posteriores a la intervención. A 10 meses de la mastectomía la paciente goza de buena salud física y psicológica, al igual que su hijo de 15 meses, y continúa en seguimiento estrecho en el servicio de Oncología.  CONCLUSIÓN: El tratamiento del cáncer de mama durante el embarazo es seguro y ofrece buenos resultados a largo plazo. Es importante la intervención y valoración multidisciplinaria, además de la asesoría correcta y el apoyo psicológico a la familia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND: Breast cancer is the most prevalent cancer nowadays and is the most common at the pregnancy and postpartum period. The incidence is between 0.2-2.6% and is currently increasing due to delayed childbearing. The treatment implies a challenge for the health systems because the welfare of the mother and her child must be valued and safeguarded.  CLINICAL CASE:  A 26-year-old patient who attended the consultation for right mastalgia, with rapid growth from the beginning of pregnancy. During the mammary examination, a hard consistency tumor of 8 cm was observed, occupying both upper quadrants of the right breast, with reddening of the skin. The ultrasound revealed a heterogeneous solid-cystic tumor, 8 x 5 cm, without pathological axillary lymph nodes. The anatomopathological study of the biopsy reported an infiltrating carcinoma, with triple negative immunophenotype (negative immunoreactivity for estrogen and progesterone receptors, and Her-2 with Ki67 proliferation index of 80%), which confirmed the diagnosis of breast cancer locally advanced in the second trimester of pregnancy. After administration of three cycles of neoadjuvant chemotherapy with anthracyclines (doxorubicin and cyclophosphamide) trisemanales, termination of pregnancy was indicated by induction of labor at week 36 + 6. A male was born at 2800 g, with Apgar 9-10- 10 The mother and her son evolved satisfactorily, so they were discharged 4 days after the intervention. Ten months after mastectomy, she enjoys good physical and psycho-logical health, as does her 15-month-old son. Continues in close monitoring in the Oncology service.  CONCLUSIONS: The treatment of breast cancer during pregnancy is safe and offers good long-term results. The important intervention and multidisciplinary assessment, in addition to the correct advice and psychological support to the family.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cáncer de mama]]></kwd>
<kwd lng="es"><![CDATA[embarazo]]></kwd>
<kwd lng="es"><![CDATA[radioterapia]]></kwd>
<kwd lng="es"><![CDATA[quimioterapia, biopsia selectiva del ganglio centinela]]></kwd>
<kwd lng="es"><![CDATA[mastectomía]]></kwd>
<kwd lng="en"><![CDATA[Breast cancer]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy]]></kwd>
<kwd lng="en"><![CDATA[Radiotherapy]]></kwd>
<kwd lng="en"><![CDATA[Chemotherapy]]></kwd>
<kwd lng="en"><![CDATA[Sentinel lymph node biopsy]]></kwd>
<kwd lng="en"><![CDATA[Mastectomy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Álvarez-Tapias]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Actualización del manejo clínico del cáncer mamario asociado al embarazo. Revisión de la Literatura]]></article-title>
<source><![CDATA[Rev Colomb Salud Libre]]></source>
<year>2017</year>
<numero>2</numero>
<issue>2</issue>
<page-range>50-9</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shim]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical characteristics and outcome of cancer diagnosed during pregnancy]]></article-title>
<source><![CDATA[Obstet Gynecol Sci.]]></source>
<year>2016</year>
<volume>59</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-8</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shlensky]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Management of Breast Cancer during Pregnancy: Are We Compliant with Current Guidelines?]]></article-title>
<source><![CDATA[Am J Perinatol Rep.]]></source>
<year>2017</year>
<volume>7</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>39-43</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sule]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Management of pregnancy associated breast cancer with chemotherapy in a developing country]]></article-title>
<source><![CDATA[Int J Surg Case Rep]]></source>
<year>2015</year>
<volume>17</volume>
<page-range>117-20</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Albalat-Fernández]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biopsia selectiva de ganglio centinela en mujer embarazada con cáncer de mama]]></article-title>
<source><![CDATA[Prog Obstet Ginecol]]></source>
<year>2015</year>
<volume>58</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>283-6</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernández-Blanquisett]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Breast cancer in pregnancy: an institutional experience]]></article-title>
<source><![CDATA[Ecancermedical science]]></source>
<year>2015</year>
<volume>9</volume>
<numero>551</numero>
<issue>551</issue>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rovera]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Breast cancer in pregnancy]]></article-title>
<source><![CDATA[Breast J]]></source>
<year>2010</year>
<volume>16</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>S22-5</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Simonescu]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Advanced metastatic breast cancer in pregnancy: the imperative of physical breast examination in pregnancy]]></article-title>
<source><![CDATA[Rom J Morphol Embryol]]></source>
<year>2017</year>
<volume>58</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>645-50</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Upadhayay]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Triple negative breast cancer in pregnancy and postpartum: two case reports in hispanic women]]></article-title>
<source><![CDATA[Case Rep Obstet Gynecol]]></source>
<year>2015</year>
<volume>2015</volume>
<page-range>856931</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zagouri]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cancer in pregnancy: disentangling treatment modalities]]></article-title>
<source><![CDATA[ESMO Open]]></source>
<year>2016</year>
<volume>1</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ye]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Study on the adverse effects following chemotherapy for breast cancer diagnosis during pregnancy]]></article-title>
<source><![CDATA[Medicine]]></source>
<year>2017</year>
<volume>96</volume>
<numero>46</numero>
<issue>46</issue>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nargotra]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pregnancy associated breast cancer: awareness is the key to diagnosis-a case report]]></article-title>
<source><![CDATA[J Clin Diagn Res]]></source>
<year>2015</year>
<volume>9</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>9-11</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<collab>International Commission on Radiological Protection</collab>
<article-title xml:lang=""><![CDATA[Pregnancy and medical radiation]]></article-title>
<source><![CDATA[Ann ICRP]]></source>
<year>2000</year>
<volume>30</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-43</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[DeSantis]]></surname>
<given-names><![CDATA[CE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cancer treatment and survivorship statistics, 2014]]></article-title>
<source><![CDATA[CA Cancer J Clin]]></source>
<year>2014</year>
<volume>64</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>252-71</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amant]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Long-term cognitive and cardiac outcomes after prenatal exposure to chemotherapy in children aged 18 months or older: an observational study]]></article-title>
<source><![CDATA[The Lancet Oncology]]></source>
<year>2012</year>
<volume>13</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>256-64</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Litton]]></surname>
<given-names><![CDATA[JK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Breast cancer and pregnancy: current concepts in diagnosis and treatment]]></article-title>
<source><![CDATA[Oncologist]]></source>
<year>2010</year>
<volume>15</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1238-47</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Peccatori]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cancer, pregnancy and fertility: ESMO clinical practice guidelines for diagnosis, treatment and follow-up]]></article-title>
<source><![CDATA[Ann Oncol]]></source>
<year>2013</year>
<numero>^s6</numero>
<issue>^s6</issue>
<supplement>6</supplement>
<page-range>160-70</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Calsteren]]></surname>
<given-names><![CDATA[KV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Transplacental transfer of paclitaxel, docetaxel, carboplatin, and trastuzumab in a baboon model]]></article-title>
<source><![CDATA[Int J Gynecol Cancer]]></source>
<year>2010</year>
<volume>20</volume>
<page-range>1456-64</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Loibl]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Treatment of breast cancer during pregnancy: an observational study]]></article-title>
<source><![CDATA[The Lancet Oncology]]></source>
<year>2012</year>
<volume>13</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>887-96</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zagouri]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Trastuzumab administration during pregnancy: a systematic review and meta-analysis]]></article-title>
<source><![CDATA[Breast Cancer Res Treat]]></source>
<year>2013</year>
<volume>137</volume>
<page-range>349-57</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amant]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prognosis of women with primary breast cancer diagnosed during pregnancy: results from an international collaborative study]]></article-title>
<source><![CDATA[J Clin Oncol]]></source>
<year>2013</year>
<volume>31</volume>
<numero>20</numero>
<issue>20</issue>
<page-range>2532-9</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gentilini]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Safety of sentinel node biopsy in pregnant patients with breast cancer]]></article-title>
<source><![CDATA[Ann Oncol]]></source>
<year>2004</year>
<volume>15</volume>
<page-range>1348-51</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
