<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412017001000676</article-id>
<article-id pub-id-type="doi">10.24245/gom.v85i10.1530</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Trombofilias y embarazo: incidencia, factores de riesgo y resultados perinatales]]></article-title>
<article-title xml:lang="en"><![CDATA[Thrombophilia and pregnancy: Incidence, risk factors and perinatal results]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez-Castañeda]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Font-López]]></surname>
<given-names><![CDATA[KC]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,ISSSTE Hospital General Fernando Quiroz Gutiérrez ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,IMSS Hospital General de Zona 1-A ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<volume>85</volume>
<numero>10</numero>
<fpage>676</fpage>
<lpage>684</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412017001000676&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412017001000676&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412017001000676&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  OBJETIVO: analizar la incidencia, los factores de riesgo y las condiciones de los recién nacidos de madres con trombofilia.  MATERIALES Y MÉTODOS: estudio observacional de serie de casos de pacientes atendidas en el Hospital General Fernando Quiroz Gutiérrez, ISSSTE, entre los años 2010 a 2016. Se incluyeron todas las embarazadas con diagnóstico de trombofilia establecido con base en el perfil de trombofilias. Todas se trataron con ácido acetil salicílico y heparina de bajo peso molecular a partir del diagnóstico. Todas se vigilaron estrechamente durante el embarazo y puerperio con seguimiento de las condiciones maternas y neonatales, que se capturaron y analizaron en una hoja de Excel.  RESULTADOS: se encontraron 81 casos que representaron una incidencia de 1.06%. La trombofilia más frecuente fue el síndrome de anticuerpos antifosfolipídicos (39.5%), seguida de la deficiencia de proteína S (35.8%). Los antecedentes de riesgo más frecuentes fueron: pérdida gestacional recurrente (63%), preeclampsia (23%) y muerte fetal (17%). Los resultados perinatales y maternos postratamiento: 97.6% de neonatos sanos, 2.4% abortos y 4.9% preeclampsia.  CONCLUSIONES:  los antecedentes de pérdida repetida de la gestación, restricción del crecimiento fetal, enfermedad hipertensiva del embarazo y muerte fetal deben despertar la sospecha de trombofilia. Con base en lo anterior debe iniciarse el protocolo de estudio para su confirmación. El nacimiento de un recién nacido es factible siempre y cuando la madre y su hijo reciban vigilancia estricta y el tratamiento oportuno.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  OBJECTIVE: To analyze the incidence, risk factors and perinatal outcomes of patients with thrombophilia and pregnancy.  MATERIALS AND METHODS:  Observational study of a series of cases at the General Hospital Fernando Quiroz Gutiérrez ISSSTE. From 2010 to 2016. We included all pregnant women with a diagnosis of thrombophilia, performed with a thrombophilia profile. Treatment with acetylsalicylic acid and low molecular weight heparin was started since diagnosis. Pregnancy and puerperium surveillance was performed with observation of results, which were captured and analyzed with the Excel program.  RESULTS:  There were 81 cases, with an incidence of 1.06%. The most frequent thrombophilia was the antiphospholipid antibody syndrome 39.5%, followed by the protein S deficiency 35.8%. The most frequent risk factors were: recurrent gestational loss 63%, preeclampsia 23% and fetal death 17%. Perinatal outcomes after treatment: 97.6% of healthy neonates, 2.4% of abortions and 4.9% of preeclampsia.  CONCLUSIONS:  A history of repeated gestational loss, fetal growth restriction, hypertensive pregnancy and fetal death should lead to suspected thrombophilia; With the obligation to carry out study protocol for confirmation. Reproductive success is feasible, if the binomial is subjected to strict monitoring and timely treatment.]]></p></abstract>
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<kwd lng="es"><![CDATA[trombofilia y embarazo]]></kwd>
<kwd lng="es"><![CDATA[pérdida gestacional recurrente]]></kwd>
<kwd lng="en"><![CDATA[Thrombophilia and pregnancy]]></kwd>
<kwd lng="en"><![CDATA[Recurrent gestational loss]]></kwd>
</kwd-group>
</article-meta>
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