<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412017000600374</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Utilidad de la albúmina oxidada y los sulfihidrilos séricos como marcadores de estrés oxidativo en pacientes embarazadas con hipertensión crónica]]></article-title>
<article-title xml:lang="en"><![CDATA[Usefulness of oxidized albumin and serum sulfhydryles as oxidative stress markers in pregnant women with chronic hypertension]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno-Uribe]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Portilla]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guzmán-Grenfell]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,IMSS Centro Médico Nacional La Raza Hospital de Gineco-Obstetricia 3]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universitat de Barcelona BCNatal Hospital Clinic de Barcelona ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Perinatología Isidro Espinosa de los Reyes  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<volume>85</volume>
<numero>6</numero>
<fpage>374</fpage>
<lpage>379</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412017000600374&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412017000600374&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412017000600374&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  OBJETIVO: determinar la utilidad de la albúmina oxidada y de los sulfihidrilos como marcadores de estrés oxidativo en pacientes embarazadas con y sin hipertensión crónica.  MATERIALES Y MÉTODOS:  estudio de cohorte prospectiva efectuado en pacientes con 28-30 semanas de gestación, con y sin hipertensión crónica. Medición por espectrofotometría directa y determinación de variables demográficas y concentraciones séricas de albúmina, albúmina oxidada, índice albúmina oxidada-albúmina sérica y sulfihidrilos. Determinación de medias y desviación estándar de las variables numéricas y proporciones de variables cualitativas. Tablas de contingencia y medidas de asociación mediante &#967;2 para variables cualitativas y U de Mann Whitney para variables cuantitativas. Los valores de p &lt; 0.005 se considerarán significativos.  RESULTADOS: se incluyeron 24 pacientes embarazadas: 10 con hipertensión crónica y 14 controles. En el grupo de hipertensión crónica 3 de cada 10 pacientes tuvieron preeclampsia. La variable resultado fue preeclampsia, diagnosticada según los criterios de la ACOG 2013. En el grupo de hipertensión crónica, en relación con el grupo control, no se encontraron diferencias significativas entre las concentraciones séricas de albúmina oxidada, índice albúmina oxidada-albúmina sérica y las concentraciones de sulfihidrilos totales.  CONCLUSIONES: quizá debido al escaso número de pacientes no se encontraron diferencias significativas en las concentraciones séricas de estrés oxidativo en mujeres con y sin hipertensión crónica. Para descartar o aceptar esta hipótesis se requieren estudios con mayor población.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND: Oxidative stress is an altered balance between antioxidant and oxidant systems, leading to cellular damage. In pregnant women with chronic hypertension, oxidative stress has been associated as an important phenomenon for the development of preeclampsia.  OBJECTIVE: To determine the usefulness of oxidized albumin and sulfhydryles as an oxidative stress marker in pregnant patients with and without chronic hypertension.  METHODS: Cohort study, which included pregnant women from 28 to 30 weeks of gestation, with and without chronic hypertension. Demographic variables serum levels of albumin; oxidized albumin; oxidized albumin/serum albumin index and sulfhydryl were measured by direct spectrophotometry. The final outcome was preeclampsia, diagnosed according to 2013 ACOG Task force. Mean and standard deviation were determined for numerical variables and proportions for qualitative variables. Contingency tables and association measures were performed using &#967;2 for qualitative variables and Mann-Whitney U test for quantitative variables. p &lt;0.005 was considered significant.  RESULTS: A total of 24 pregnant women were included, 10 with chronic hypertension and 14 controls. In the chronic hypertension group 3/10 patients developed preeclampsia. No significant differences were found between serum levels of oxidized albumin, oxidized albumin-serum albumin index, and total sulfhydryl levels in the chronic hypertension group in relation to the control group.  CONCLUSIONS: In this study, no significant differences were found in oxidative stress molecules serum levels in women with and without chronic hypertension. This may be due to the small number of cases, which requires studies with larger population to rule out this hypothesis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[embarazo]]></kwd>
<kwd lng="es"><![CDATA[hipertensión crónica]]></kwd>
<kwd lng="es"><![CDATA[preeclampsia]]></kwd>
<kwd lng="es"><![CDATA[sulfihidrilos]]></kwd>
<kwd lng="es"><![CDATA[albúmina oxidada]]></kwd>
<kwd lng="es"><![CDATA[estrés oxidativo]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy]]></kwd>
<kwd lng="en"><![CDATA[Chronic hypertension]]></kwd>
<kwd lng="en"><![CDATA[Preeclampsia]]></kwd>
<kwd lng="en"><![CDATA[Sulfhydryl]]></kwd>
<kwd lng="en"><![CDATA[Oxidized albumin]]></kwd>
<kwd lng="en"><![CDATA[Oxidative stress]]></kwd>
</kwd-group>
</article-meta>
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