<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0188-9532</journal-id>
<journal-title><![CDATA[Revista mexicana de ingeniería biomédica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. ing. bioméd]]></abbrev-journal-title>
<issn>0188-9532</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Ingeniería Biomédica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0188-95322025000100103</article-id>
<article-id pub-id-type="doi">10.17488/rmib.46.1.1484</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Allium cepa: A natural enhancer of wound closure and cell viability in O-carboxymethyl chitosan films]]></article-title>
<article-title xml:lang="es"><![CDATA[Allium cepa: potenciador natural del cierre de heridas y viabilidad celular en películas de O-carboximetil quitosano]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valencia-Gómez]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-González]]></surname>
<given-names><![CDATA[Claudia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilar Valenzuela]]></surname>
<given-names><![CDATA[Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miranda Cabrera]]></surname>
<given-names><![CDATA[Faviola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez López]]></surname>
<given-names><![CDATA[Kenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Paz]]></surname>
<given-names><![CDATA[Juan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes Blas]]></surname>
<given-names><![CDATA[Hortensia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sáenz Villela]]></surname>
<given-names><![CDATA[Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Olivas Armendáriz]]></surname>
<given-names><![CDATA[Imelda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Ciudad Juárez  ]]></institution>
<addr-line><![CDATA[Chihuahua ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<volume>46</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0188-95322025000100103&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0188-95322025000100103&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0188-95322025000100103&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Wound healing and cicatrization after tissue damage are essential for the body's recovery process. Regenerative medicine has been focused on finding biocompatible polymeric materials reinforced with natural active substances, which have healing, anti-inflammatory, and antimicrobial properties. This study aimed to enhance O-carboxymethyl chitosan films with Allium cepa extracts, endemic to Chihuahua, Mexico. The extract's properties were analyzed, and the results show the saponin, flavonoid, and terpenoid contents and an antioxidant activity of 70 %. Cicatrization in vitro was also studied, and the results show that a 15 mg/mL concentration of the Allium cepa extracts improved cellular proliferation and migration in fibroblasts, which was further confirmed in a cellular viability study of the O-carboxymethyl chitosan films loaded with 7 and 20 wt. % of the extract, which showed a higher percentage of cellular viability after three days. The study's results suggest that low extract concentrations can be used as an active ingredient in polymeric biomaterials to aid skin cicatrization.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La cicatrización de heridas y el daño en los tejidos son fundamentales para la recuperación del organismo. La medicina regenerativa se ha centrado en desarrollar materiales poliméricos biocompatibles, enriquecidos con principios activos naturales, que posean propiedades cicatrizantes, antiinflamatorias y antimicrobianas. Este estudio tuvo como objetivo mejorar el desempeño de películas de O-carboximetil quitosano utilizando extractos de Allium cepa, una planta endémica de Chihuahua, México. Se analizaron las propiedades del extracto, encontrando un contenido significativo de saponinas, flavonoides y terpenoides, así como una actividad antioxidante del 70 %. La cicatrización in vitro indica que una concentración de 15 mg/mL de extracto de Allium cepa potencia la proliferación y migración celular en fibroblastos. Esta mejora se confirmó en un estudio de viabilidad celular de las películas de O-carboximetil quitosano cargadas con 7 y 20 wt. % mg del extracto, las cuales mostraron un mayor porcentaje de viabilidad celular después de tres días. Los hallazgos sugieren que concentraciones bajas del extracto pueden ser utilizadas como ingredientes activos en biomateriales poliméricos, contribuyendo así a la cicatrización de la piel.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Allium cepa]]></kwd>
<kwd lng="en"><![CDATA[O-carboxymethyl chitosan]]></kwd>
<kwd lng="en"><![CDATA[tissue regeneration]]></kwd>
<kwd lng="en"><![CDATA[wound healing]]></kwd>
<kwd lng="es"><![CDATA[Allium cepa]]></kwd>
<kwd lng="es"><![CDATA[O-carboximetil quitosano]]></kwd>
<kwd lng="es"><![CDATA[ingeniería tisular]]></kwd>
<kwd lng="es"><![CDATA[cicatrización]]></kwd>
</kwd-group>
</article-meta>
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