<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0187-893X</journal-id>
<journal-title><![CDATA[Educación química]]></journal-title>
<abbrev-journal-title><![CDATA[Educ. quím]]></abbrev-journal-title>
<issn>0187-893X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Química]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0187-893X2022000100050</article-id>
<article-id pub-id-type="doi">10.22201/fq.18708404e.2022.1.78881</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[De la Mioglobina al SARS-CoV-2: ¡50 años del Protein Data Bank!]]></article-title>
<article-title xml:lang="en"><![CDATA[From Myoglobin to SARS-CoV-2: ¡50 years of the Protein Data Bank!]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Lara]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Benemérita Universidad Autónoma de Puebla  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>33</volume>
<numero>1</numero>
<fpage>50</fpage>
<lpage>63</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0187-893X2022000100050&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0187-893X2022000100050&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0187-893X2022000100050&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La Mioglobina fue la primer proteína visualizada en tres dimensiones (3D) a través de la cristalografía de rayos-X, sentando las bases para una nueva era de comprensión biológica. A partir de este hecho, se comenzaron a determinar estructuralmente una serie de macromoléculas de considerable interés biológico. Sin embargo, este impresionante avance en las ciencias de la vida, contrastaba radicalmente con la ausencia de un repositorio global para archivar y compartir los datos cristalográficos colectados de los experimentos de difracción. Con el propósito de llenar este vacío, en 1971 se estableció el Protein Data Bank (PDB) en el Brookhaven National Laboratory, como el único almacén central de estructuras 3D de macromoléculas biológicas. Establecido con apenas siete estructuras, el PDB ha evolucionado a un gigantesco repositorio de acceso abierto, almacenando datos estructurales de más de 170,000 biomoléculas, principalmente de proteínas y ácidos nucleicos. Además de ser un banco de datos biológicos, el PDB sirve como un portal educativo a través del PDB-101, ofreciendo un conjunto de recursos extraordinarios para admirar el mundo biológico. En esta revisión, festejamos los 50 años de oro del PDB con una mirada a su historia y un recorrido por algunas herramientas educativas que el archivo pone a disposición de estudiantes, investigadores, profesores y público no especializado. Ilustramos el valor de estos recursos con la estructura 3D de la maquinaria biológica recientemente depositada en el archivo, del ubicuo y nuevo coronavirus causante del síndrome respiratorio agudo severo (SARS-CoV-2) o COVID-19.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Myoglobin was the first protein visualized in 3D by X-ray crystallography, laying the foundation for a new era of biological understanding. From this point, a series of macromolecules of considerable biological interest began to be structurally determined. However, this extraordinary advance in life sciences contrasted with the absence of a global repository for archiving and sharing crystallographic data obtained from X-ray diffraction experiments. To fill this gap, the Protein Data Bank (PDB) was established at Brookhaven National Laboratory in 1971, as an archive for biological macromolecules crystal structures. Established with just seven structures, the PDB has become a remarkable open-access database, storing structural data of more than 175,000 biomolecules, primarily proteins, DNA and RNA, and their complexes with associated small molecules. In addition to being a biological database, the PDB acts as an educational resource through PDB-101, offering a set of extraordinary tools for admiring the biological world. In this work, we celebrate the PDB&#8217;s 50th golden anniversary with a look at its history and a journey through some of the free tools the archive makes available to students, teachers, researchers, and the general audience. We have illustrated the value of these online educational resources with the archive´s recently deposited 3D biological machinery structure of the new severe acute respiratory syndrome-causing coronavirus (SARS-CoV-2) or COVID-19.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cristalografía de rayos-X]]></kwd>
<kwd lng="es"><![CDATA[Biología estructural]]></kwd>
<kwd lng="es"><![CDATA[Proteínas]]></kwd>
<kwd lng="es"><![CDATA[Virus]]></kwd>
<kwd lng="es"><![CDATA[Recursos Educativos]]></kwd>
<kwd lng="es"><![CDATA[Divulgación científica]]></kwd>
<kwd lng="en"><![CDATA[X-ray crystallography]]></kwd>
<kwd lng="en"><![CDATA[Structural biology]]></kwd>
<kwd lng="en"><![CDATA[Proteins]]></kwd>
<kwd lng="en"><![CDATA[Virus]]></kwd>
<kwd lng="en"><![CDATA[Educational resources]]></kwd>
<kwd lng="en"><![CDATA[Popular science]]></kwd>
</kwd-group>
</article-meta>
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