<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662018000300005</article-id>
<article-id pub-id-type="doi">10.24245/mim.v34i3.1994</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Utilidad de la prueba de detección de ácidos nucleicos GeneXpert tuberculosis (MTB/RIF) en muestras respiratorias y no respiratorias en un hospital de referencia]]></article-title>
<article-title xml:lang="en"><![CDATA[Utility of nucleic acids detection GeneXpert tuberculosis (MTB/RIF) in respiratory and non-respiratory hospital reference samples.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Borraz-Noriega]]></surname>
<given-names><![CDATA[Darío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Robledo-Pascual]]></surname>
<given-names><![CDATA[Julio César]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres-Pérez]]></surname>
<given-names><![CDATA[Jorge Alonso]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores-Barrientos]]></surname>
<given-names><![CDATA[Oscar Israel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de Alta Especialidad Dr. Juan Graham Casasús  ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Alta Especialidad Dr. Juan Graham Casasús Departamento de Neumología ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital de Alta Especialidad Dr. Juan Graham Casasús Departamento de Medicina Interna ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital de Alta Especialidad Dr. Juan Graham Casasús Departamento de Infectología ]]></institution>
<addr-line><![CDATA[Villahermosa Tabasco]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<volume>34</volume>
<numero>3</numero>
<fpage>381</fpage>
<lpage>387</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662018000300005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662018000300005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662018000300005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  OBJETIVO Evaluar la sensibilidad y valores predictivos de BAAR-Ziehl-Neelsen y GeneXpert (MTB/RIF) en muestras respiratorias y no respiratorias en población general y con VIH.  MATERIAL Y MÉTODO  Estudio clínico abierto, sin distribución al azar, prospectivo, descriptivo y observacional efectuado de mayo de 2016 a enero de 2017. Los criterios de inclusión fueron: pacientes con datos clínicos epidemiológicos radiológicos que sugirieran tuberculosis en la evaluación diagnóstica o riesgo de padecerla. Se hizo toma simultánea de expectoración o muestra extrapulmonar para determinación de BAAR-Ziehl-Neelsen, GeneXpert MTB y cultivo; se utilizó como patrón de referencia el cultivo.  RESULTADOS Se incluyeron en el estudio 120 pacientes, 88 (73.3%) hombres. La justificación de la realización de la prueba fue enfermedad aguda grave 76 (63.3%), el factor de riesgo de mayor prevalencia fue el VIH-SIDA 54 (45.5%). El mayor porcentaje correspondió a la forma respiratoria (n = 75, 62.5%). El total de las muestras (n = 89, 74.2%) fueron negativas respecto a BAAR en contraste con GeneXpert y cultivo, que fueron positivos en 94 casos (78.3%).  CONCLUSIONES Los indicadores estables evaluados en la prueba GeneXpert mostraron que es una prueba útil, sobre todo en muestras extrapulmonares de pacientes con VIH-SIDA.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  OBJECTIVE To assess the sensitivity and predictive values of BAAR Ziehl-Neelsen and GeneXpert (MTB/RIF) for respiratory and non-respiratory samples in the general population and HIV-patients.  MATERIAL AND METHOD  A clinical open, not-random, prospective, descriptive and observational study was done from May 2016 to January 2017. Inclusion criteria were: Patients with radiological, clinical and epidemiological data that suggested tuberculosis within the diagnostic evaluation or risk of having it. Simultaneous sputum or extrapulmonary sample was taken for determination of Ziehl-Neelsen, GeneXpert MTB and culture; the crop was used as a gold standard.  RESULTS  There were included 120 patients, 88 (73.3%) men; the justification for performing the test was severe acute disease (n = 76, 63.3%), the risk factor with the highest prevalence was HIV-AIDS (n = 54, 45.5%) The highest percentage was respiratory (n = 75, 62.5%). The total of samples 89 (74.2%) were negative with respect to BAAR in contrast to GeneXpert and culture, which reported positive in 94 (78.3%).  CONCLUSIONS The stable indicators evaluated in the GeneXpert test showed that it is a useful test especially in extralung samples of patients with HIV-AIDS.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Tuberculosis]]></kwd>
<kwd lng="es"><![CDATA[tuberculosis fármaco-resistente]]></kwd>
<kwd lng="en"><![CDATA[Tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[Tuberculosis drug resistant]]></kwd>
</kwd-group>
</article-meta>
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