<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662017000600770</article-id>
<article-id pub-id-type="doi">10.24245/mim.v33i6.1672</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La adiponectina como blanco terapéutico]]></article-title>
<article-title xml:lang="en"><![CDATA[Adiponectin as therapeutic target.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Romero]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alarcón-Sotelo]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Weber]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Greene]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad La Salle Facultad Mexicana de Medicina ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad La Salle Facultad Mexicana de Medicina ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad La Salle Facultad Mexicana de Medicina ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>33</volume>
<numero>6</numero>
<fpage>770</fpage>
<lpage>777</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662017000600770&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662017000600770&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662017000600770&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La adiponectina es una adipocina con acciones ubicuas, con propiedades antiinflamatorias y efectos antiapoptósicos. Entre sus acciones, esta proteína aumenta la sensibilidad a la insulina y disminuye el riesgo cardiovascular. Las concentraciones reducidas de adiponectina se asocian con mayor riesgo de diabetes mellitus tipo 2, síndrome metabólico, aterosclerosis y enfermedades cardiovasculares. Debido a esta evidencia, los esfuerzos de los estudios básicos y clínicos se han enfilado a ampliar la comprensión del metabolismo de esta proteína, así como al desarrollo de métodos para modular su concentración y su bioactividad como prometedoras herramientas terapéuticas. El objetivo de este trabajo es revisar el metabolismo de la adiponectina y explorar su utilidad como objetivo terapéutico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Adiponectin is an adipokine with ubiquitous actions, anti-inflammatory properties and antiapoptotic effects. Among its actions, this protein increases insulin sensitivity and reduces cardiovascular risk. A reduced level of adiponectin is associated with an increased risk of developing type 2 diabetes mellitus, metabolic syndrome, atherosclerosis and cardiovascular disease. Due to this evidence, the efforts of the basic and clinical studies have been directed to increase the understanding of the metabolism of this protein, as well as to develop methods to modulate its concentration and its bioactivity. The aim of this work is to review the metabolism of adiponectin and to explore its usefulness as a therapeutic target.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[adiponectina]]></kwd>
<kwd lng="es"><![CDATA[obesidad]]></kwd>
<kwd lng="es"><![CDATA[aterosclerosis]]></kwd>
<kwd lng="es"><![CDATA[riesgo cardiovascular]]></kwd>
<kwd lng="en"><![CDATA[adiponectin]]></kwd>
<kwd lng="en"><![CDATA[obesity]]></kwd>
<kwd lng="en"><![CDATA[atherosclerosis]]></kwd>
<kwd lng="en"><![CDATA[cardiovascular risk]]></kwd>
</kwd-group>
</article-meta>
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