<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0035-0052</journal-id>
<journal-title><![CDATA[Revista mexicana de pediatría]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. pediatr.]]></abbrev-journal-title>
<issn>0035-0052</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Pediatría A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0035-00522021000500204</article-id>
<article-id pub-id-type="doi">10.35366/103902</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Sintelencefalia en una recién nacida]]></article-title>
<article-title xml:lang="en"><![CDATA[Syntelencephaly in a newborn]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Espinosa]]></surname>
<given-names><![CDATA[Patricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villareal-Garza]]></surname>
<given-names><![CDATA[Estefanía]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Nuevo León Hospital Universitario &#8220;Dr. José Eleuterio González&#8221; Servicio de Neurología]]></institution>
<addr-line><![CDATA[Monterrey ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2021</year>
</pub-date>
<volume>88</volume>
<numero>5</numero>
<fpage>204</fpage>
<lpage>208</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0035-00522021000500204&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0035-00522021000500204&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0035-00522021000500204&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  La sintelencefalia es una malformación del cerebro anterior, la cual es una variante de holoprosencefalia. Se han publicado pocos casos en la literatura latinoamericana.  Presentación del caso:  Paciente femenino, hija de madre diabética. Se hace diagnóstico de holoprosencefalia a las 21 semanas de gestación. Al nacimiento también se detectó labio y paladar hendido, pie equino varo, ectasia pielocalicial bilateral y cardiopatía congénita compleja. Por esta última, la paciente fallece en la primera semana de vida. Mediante resonancia magnética se identificaron las imágenes compatibles con sintelencefalia.  Conclusiones:  Los pacientes con sintelencefalia y que, además, tienen otras múltiples enfermedades congénitas tienen un pronóstico desfavorable. Su manejo debe ser multidisciplinario, incluyendo especialistas de Genética.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  Syntelencephaly is a forebrain malformation, which is a variant of holoprosencephaly. Few cases have been published in the Latin American literature.  Case presentation:  Female newborn, daughter of a diabetic mother. Diagnosis of holoprosencephaly is made at 21 weeks&#8217; gestation. At birth, cleft lip and palate, clubfoot, bilateral pyelocaliceal ectasia, and complex congenital heart disease were also detected. Because of the latter, the patient died in the first week of life. Magnetic resonance images compatible with syntelencephaly were identified.  Conclusions:  Patients with syntelencephaly and other congenital multiples have a poor prognosis. Its management should be multidisciplinary, including Genetics specialists.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Holoprosencefalia]]></kwd>
<kwd lng="es"><![CDATA[recién nacido]]></kwd>
<kwd lng="es"><![CDATA[sintelencefalia]]></kwd>
<kwd lng="es"><![CDATA[cardiopatía congénita]]></kwd>
<kwd lng="es"><![CDATA[labio y paladar hendidos]]></kwd>
<kwd lng="en"><![CDATA[Holoprosencephaly]]></kwd>
<kwd lng="en"><![CDATA[newborn]]></kwd>
<kwd lng="en"><![CDATA[syntelencephaly]]></kwd>
<kwd lng="en"><![CDATA[congenital heart disease]]></kwd>
<kwd lng="en"><![CDATA[cleft lip-palate]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gropman]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Muenke]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Holoprosencephaly]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Cassidy]]></surname>
<given-names><![CDATA[SB]]></given-names>
</name>
<name>
<surname><![CDATA[Allanson]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
</person-group>
<source><![CDATA[Management of Genetic Syndromes]]></source>
<year>2005</year>
<page-range>279-96</page-range><publisher-loc><![CDATA[New York, NY ]]></publisher-loc>
<publisher-name><![CDATA[Wiley-Liss, Inc]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dubourg]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Bendavid]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Pasquier]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Henry]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Odent]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[David]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Holoprosencephaly]]></article-title>
<source><![CDATA[Orphanet J Rare Dis]]></source>
<year>2007</year>
<volume>2</volume>
<page-range>8</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Grinblat]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Lipinski]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A forebrain undivided: unleashing model organisms to solve the mysteries of holoprosencephaly]]></article-title>
<source><![CDATA[Dev Dyn]]></source>
<year>2019</year>
<volume>248</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>626-33</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Roessler]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Vélez]]></surname>
<given-names><![CDATA[JI]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Muenke]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Utilizing prospective sequence analysis of SHH, ZIC2, SIX3 and TGIF in holoprosencephaly probands to describe the parameters limiting the observed frequency of mutant gene×gene interactions]]></article-title>
<source><![CDATA[Mol Genet Metab]]></source>
<year>2012</year>
<volume>105</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>658-64</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lacbawan]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Solomon]]></surname>
<given-names><![CDATA[BD]]></given-names>
</name>
<name>
<surname><![CDATA[Roessler]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[El-Jaick]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Domené]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Vélez]]></surname>
<given-names><![CDATA[JI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical spectrum of SIX3-associated mutations in holoprosencephaly: correlation between genotype, phenotype and function]]></article-title>
<source><![CDATA[J Med Genet]]></source>
<year>2009</year>
<volume>46</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>389-98</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Orioli]]></surname>
<given-names><![CDATA[IM]]></given-names>
</name>
<name>
<surname><![CDATA[Amar]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Bakker]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
<name>
<surname><![CDATA[Bermejo-Sánchez]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Bianchi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Canfield]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cyclopia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research]]></article-title>
<source><![CDATA[Am J Med Genet C Semin Med Genet]]></source>
<year>2011</year>
<volume>157C</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>344-57</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Johnson]]></surname>
<given-names><![CDATA[CY]]></given-names>
</name>
<name>
<surname><![CDATA[Rasmussen]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Non-genetic risk factors for holoprosencephaly]]></article-title>
<source><![CDATA[Am J Med Genet C Semin Med Genet]]></source>
<year>2010</year>
<volume>154C</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>73-85</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Summers]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
<name>
<surname><![CDATA[Reefhuis]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Taliano]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Rasmussen]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nongenetic risk factors for holoprosencephaly: An updated review of the epidemiologic literature]]></article-title>
<source><![CDATA[Am J Med Genet C Semin Med Genet]]></source>
<year>2018</year>
<volume>178</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>151-64</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schroeder]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
<name>
<surname><![CDATA[Privalsky]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thyroid hormones, t3 and t4, in the brain]]></article-title>
<source><![CDATA[Front Endocrinol (Lausanne)]]></source>
<year>2014</year>
<volume>5</volume>
<page-range>40</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rajalakshmi]]></surname>
<given-names><![CDATA[PP]]></given-names>
</name>
<name>
<surname><![CDATA[Gadodia]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Priyatharshini]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Middle interhemispheric variant of holoprosencephaly: A rare midline malformation]]></article-title>
<source><![CDATA[J Pediatr Neurosci]]></source>
<year>2015</year>
<volume>10</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>244-6</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Takanashi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Barkovich]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Clegg]]></surname>
<given-names><![CDATA[NJ]]></given-names>
</name>
<name>
<surname><![CDATA[Delgado]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Middle interhemispheric variant of holoprosencephaly associated with diffuse polymicrogyria]]></article-title>
<source><![CDATA[AJNR Am J Neuroradiol]]></source>
<year>2003</year>
<volume>24</volume>
<page-range>394-7</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Simon]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
<name>
<surname><![CDATA[Barkovich]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Clegg]]></surname>
<given-names><![CDATA[NJ]]></given-names>
</name>
<name>
<surname><![CDATA[Delgado]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
<name>
<surname><![CDATA[Levey]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Middle interhemispheric variant of holoprosencephaly: a distinct cliniconeuroradiologic subtype]]></article-title>
<source><![CDATA[Neurology]]></source>
<year>2002</year>
<volume>59</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1860-5</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[DeMyer]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Holoprosencephaly (cyclopia-arhinencephaly)]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Vinken]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Bruyn]]></surname>
<given-names><![CDATA[GW]]></given-names>
</name>
<name>
<surname><![CDATA[Klawans]]></surname>
<given-names><![CDATA[HL]]></given-names>
</name>
</person-group>
<source><![CDATA[Handbook of clinical neurology. Revised series]]></source>
<year>1987</year>
<edition>6</edition>
<page-range>225-44</page-range><publisher-loc><![CDATA[Amsterdam ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier Science Publishers]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hahn]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Barnes]]></surname>
<given-names><![CDATA[PD]]></given-names>
</name>
<name>
<surname><![CDATA[Clegg]]></surname>
<given-names><![CDATA[NJ]]></given-names>
</name>
<name>
<surname><![CDATA[Stashinko]]></surname>
<given-names><![CDATA[EE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Septopreoptic holoprosencephaly: a mild subtype associated with midline craniofacial anomalies]]></article-title>
<source><![CDATA[AJNR Am J Neuroradiol]]></source>
<year>2010</year>
<volume>31</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1596-601</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barkovich]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Fram]]></surname>
<given-names><![CDATA[EK]]></given-names>
</name>
<name>
<surname><![CDATA[Norman]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Septo-optic dysplasia: MR imaging]]></article-title>
<source><![CDATA[Radiology]]></source>
<year>1989</year>
<volume>171</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>189-92</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hahn]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Barnes]]></surname>
<given-names><![CDATA[PD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neuroimaging advances in holoprosencephaly: refining the spectrum of the midline malformation]]></article-title>
<source><![CDATA[Am J Med Genet C Semin Med Genet]]></source>
<year>2010</year>
<volume>154C</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>120-32</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wah]]></surname>
<given-names><![CDATA[IYM]]></given-names>
</name>
<name>
<surname><![CDATA[Pooh]]></surname>
<given-names><![CDATA[RK]]></given-names>
</name>
<name>
<surname><![CDATA[Choy]]></surname>
<given-names><![CDATA[KW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular genetics in fetal neurology]]></article-title>
<source><![CDATA[Semin Fetal Neo Med]]></source>
<year>2012</year>
<volume>17</volume>
<page-range>341-6</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Clapés]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Suárez]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Oxidative stress and birth defects in infants of women with pregestational diabetes]]></article-title>
<source><![CDATA[MEDICC Review]]></source>
<year>2013</year>
<volume>15</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>37-40</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Joslin]]></surname>
<given-names><![CDATA[EP]]></given-names>
</name>
</person-group>
<source><![CDATA[Treatment of diabetes mellitus]]></source>
<year>1923</year>
<publisher-loc><![CDATA[Philadelphia ]]></publisher-loc>
<publisher-name><![CDATA[Lea and Febiger]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kitzmiller]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Gavin]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Gin]]></surname>
<given-names><![CDATA[GD]]></given-names>
</name>
<name>
<surname><![CDATA[Jovanovic-Peterson]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Main]]></surname>
<given-names><![CDATA[EK]]></given-names>
</name>
<name>
<surname><![CDATA[Zigrang]]></surname>
<given-names><![CDATA[WD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preconception care of diabetes. Glycemic control prevents congenital anomalies]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>1991</year>
<volume>265</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>731-6</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Reece]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[New concepts in diabetic embryopathy]]></article-title>
<source><![CDATA[Clin Lab Med]]></source>
<year>2013</year>
<volume>33</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>207-33</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Harris]]></surname>
<given-names><![CDATA[MI]]></given-names>
</name>
<name>
<surname><![CDATA[Flegal]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[Cowie]]></surname>
<given-names><![CDATA[CC]]></given-names>
</name>
<name>
<surname><![CDATA[Eberhardt]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Goldstein]]></surname>
<given-names><![CDATA[DE]]></given-names>
</name>
<name>
<surname><![CDATA[Little]]></surname>
<given-names><![CDATA[RR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988-1994]]></article-title>
<source><![CDATA[Diabetes Care]]></source>
<year>1998</year>
<volume>21</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>518-24</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castilla]]></surname>
<given-names><![CDATA[EE]]></given-names>
</name>
<name>
<surname><![CDATA[Orioli]]></surname>
<given-names><![CDATA[IM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ECLAMC: the Latin-American collaborative study of congenital malformations]]></article-title>
<source><![CDATA[Community Genet]]></source>
<year>2004</year>
<volume>7</volume>
<numero>2-3</numero>
<issue>2-3</issue>
<page-range>76-94</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alfonso]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Papazian]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Sinisterra]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Malformaciones cerebrales en el recién nacido: holoprosencefalia y agenesia del cuerpo calloso]]></article-title>
<source><![CDATA[Rev Neurol]]></source>
<year>2003</year>
<volume>36</volume>
<page-range>179-84</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kagan]]></surname>
<given-names><![CDATA[KO]]></given-names>
</name>
<name>
<surname><![CDATA[Staboulidou]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Syngelaki]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cruz]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Nicolaides]]></surname>
<given-names><![CDATA[KH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The 11-13-week scan: diagnosis and outcome of holoprosencephaly, exomphalos and megacystis]]></article-title>
<source><![CDATA[Ultrasound Obstet Gynecol]]></source>
<year>2010</year>
<volume>36</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>10-4</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Petracchi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Crespo]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Michia]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Igarzabal]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Gadow]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Holoprosencephaly at prenatal diagnosis: analysis of 28 cases regarding etiopathogenic diagnoses]]></article-title>
<source><![CDATA[Prenat Diagn]]></source>
<year>2011</year>
<volume>31</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>887-91</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kruszka]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Muenke]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Syndromes associated with holoprosencephaly]]></article-title>
<source><![CDATA[Am J Med Genet C Semin Med Genet]]></source>
<year>2018</year>
<volume>178</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>229-37</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dubourg]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Carré]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Hamdi-Rozé]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Mouden]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Roume]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Abdelmajid]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mutational spectrum in holoprosencephaly shows that FGF is a new major signaling pathway]]></article-title>
<source><![CDATA[Hum Mutat]]></source>
<year>2016</year>
<volume>37</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1329-39</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Roessler]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Muenke]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Holoprosencephaly in the genomics era]]></article-title>
<source><![CDATA[Am J Med Genet C Semin Med Genet]]></source>
<year>2018</year>
<volume>178</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>165-74</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
