<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0028-3746</journal-id>
<journal-title><![CDATA[Neumología y cirugía de tórax]]></journal-title>
<abbrev-journal-title><![CDATA[Neumol. cir. torax]]></abbrev-journal-title>
<issn>0028-3746</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Neumología y Cirugía de Tórax; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas; Sociedad Cubana de Neumología; Sociedad Paraguaya de Neumología; Sociedad Boliviana de Neumología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0028-37462023000100049</article-id>
<article-id pub-id-type="doi">10.35366/114231</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tumor de células germinales mixtas extragonadal primario de mediastino. Reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Primary extragonadal mixed germ cell tumor of the mediastinum. Case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Zazueta]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miyagui-Adame]]></surname>
<given-names><![CDATA[Kiyoshi Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gamez-Sainz]]></surname>
<given-names><![CDATA[Ilse Lorenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Galaviz-Humo]]></surname>
<given-names><![CDATA[Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Hospital de Especialidades No. 2 Luis Donaldo Colosio Murrieta. Centro Médico Nacional del Noroeste Unidad Médica de Alta Especialidad]]></institution>
<addr-line><![CDATA[Ciudad Obregón Sonora]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<volume>82</volume>
<numero>1</numero>
<fpage>49</fpage>
<lpage>52</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0028-37462023000100049&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0028-37462023000100049&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0028-37462023000100049&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Los tumores germinales suelen ser neoplásicas ubicadas en testículos u ovarios, manifestadas en edades tempranas de la vida. Los tumores extragonadales de células germinativas son infrecuentes, representan de 1 a 3% de las neoplasias germinales; cuando se presentan, generalmente son de una a dos estirpes, el mediastino anterior es el sitio más común. Suelen ser asintomáticos en 20-40% de los pacientes; hasta que hay compresión u obstrucción de las estructuras cercanas existe sintomatología. Presentamos el caso de un varón joven de 22 años sin comorbilidades, quien inició con tos sin predominio de horario, hemoptisis, fiebre, pérdida de peso no intencionada, diaforesis, ortopnea. A la exploración física destacaba síndrome pleuropulmonar de condensación; se realizaron estudios de gabinete, al inicio radiografía de tórax confirmando por tomografía de tórax, abdomen, pelvis, ultrasonido testicular y estudios séricos, masa en mediastino localizada en compartimiento anterior. Se realizó toma de biopsia y extirpación de masa mediastinal; concluye en un tumor extragonadal de células germinales mixtas primario de mediastino compuesto por tres extirpes celulares, representando un reto diagnóstico por su gran tamaño. Se ofreció tratamiento con quimioterapia a base de bleomicina, etopósido, cisplatino en cuatro ciclos, sin nuevas recaídas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Germ cell tumors are usually neoplastic located in the testicles or ovaries manifested in early life. Extragonadal germ cell tumors are infrequent, representing 1 to 3% of extragonadal germ cell neoplasms. When they present, they are usually 1 to 2 excisions, the anterior mediastinum representing the most common site. They are usually asymptomatic in 20-40% of patients until there is compression or obstruction of nearby structures and there are no symptoms. We present the case of a 22 year old male without comorbidities who started with cough without hourly predominance, hemoptysis, fever, unintentional weight loss, diaphoresis, orthopnea, physical examination revealed pleuropulmonary condensation syndrome, cabinet studies were performed. initially chest X-ray confirmed by tomography chest, abdomen, pelvis, testicular ultrasound and serum studies a mass in the mediastinum located in the anterior compartment, a biopsy was taken and removal of the mediastinal mass, concluding in a primary extragonadal tumor of mixed germ cells of the mediastinum composed of three cell excisions, representing a diagnostic challenge due to their large size. were re offered treatment with chemotherapy based on bleomycin, etoposide, and cisplatin in four cycles without new relapses.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[tumor germinal mixto]]></kwd>
<kwd lng="es"><![CDATA[alfafetoproteína]]></kwd>
<kwd lng="es"><![CDATA[mediastino]]></kwd>
<kwd lng="en"><![CDATA[mixed germ cell tumor]]></kwd>
<kwd lng="en"><![CDATA[alpha-fetoprotein]]></kwd>
<kwd lng="en"><![CDATA[mediastinum]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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