<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422021000100007</article-id>
<article-id pub-id-type="doi">10.22201/fm.24484865e.2021.64.1.02</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Hueso: alteraciones relacionadas con obesidad]]></article-title>
<article-title xml:lang="en"><![CDATA[Bone: Obesity-Related Disorders]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rico-Rosillo]]></surname>
<given-names><![CDATA[María Guadalupe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vega-Robledo]]></surname>
<given-names><![CDATA[Gloria Bertha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2021</year>
</pub-date>
<volume>64</volume>
<numero>1</numero>
<fpage>7</fpage>
<lpage>16</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422021000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422021000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422021000100007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El tejido óseo, anteriormente considerado como una estructura mecánica de soporte y movimiento, ha mostrado una participación importante en la homeostasis del organismo, incluyendo al metabolismo energético y el tejido adiposo. En la actualidad se considera un órgano endócrino que sintetiza moléculas reguladoras del metabolismo denominadas osteocinas. A su vez, el tejido adiposo, considerado como una glándula de secreción interna, ayuda a mantener la reserva energética del organismo y produce proteínas y moléculas como las adipocinas, algunas de las cuales afectan directamente al hueso. El análisis del ciclo resorción/formación ósea, muestra que la masa ósea es reflejo del balance entre ambas. Cuando se pierde este balance y hay reducción de la masa ósea con aumento de la fragilidad, aparece la osteoporosis lo que incrementa el riesgo de fractura. Una de cada 3 mujeres y 1 de cada 5 hombres mayores de 50 años presenta una fractura por osteoporosis. La interacción entre tejido adiposo y hueso está mediada por citocinas, osteocinas y adipocinas. La obesidad puede incidir en el hueso por varios mecanismos entre los cuales se encuentran los inflamatorios y los inducidos por citocinas derivadas de los adipocitos como la leptina y la adiponectina que pueden modificar el metabolismo óseo. Evidencias apoyan el efecto negativo de la obesidad sobre la salud del hueso, aunque estudios al respecto aún son contradictorios.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: The bone tissue, previously considered as a mechanical support for structure and movement, has shown an important participation in the homeostasis of the body, including energy metabolism and adipose tissue. Currently, it is considered an endocrine organ that synthesizes regulatory molecules of metabolism called osteokines. At the same time, the adipose tissue, considered as an internal secretion gland, helps to maintain the body energy and produces proteins and mol ecules such as adipokines, some of which affect the bone directly. The analysis of bone resorption/formation cycle shows that bone mass is a reflection of the balance between both. When this balance is lost and there is a reduction of bone mass with increased fragility, osteoporosis appears and increases the risk of fracture. One in three women and one in five men over 50 years old have a fracture due to osteoporosis. The interaction between adipose tissue and bone is mediated by cytokines, osteokines and adipokines. Obesity may affect the bone by several mechanisms, among which the inflammatory is included and those induced by cytokines secreted by adipocytes such as leptin and adiponectin which can modify bone metabolism. Evidence supports the negative effect of obesity on bone health, although studies about it are still contradictory.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Obesidad]]></kwd>
<kwd lng="es"><![CDATA[hueso]]></kwd>
<kwd lng="es"><![CDATA[adipocinas]]></kwd>
<kwd lng="es"><![CDATA[osteoporosis]]></kwd>
<kwd lng="es"><![CDATA[osteoblasto]]></kwd>
<kwd lng="es"><![CDATA[osteoclasto]]></kwd>
<kwd lng="en"><![CDATA[Obesity]]></kwd>
<kwd lng="en"><![CDATA[bone]]></kwd>
<kwd lng="en"><![CDATA[adipokines]]></kwd>
<kwd lng="en"><![CDATA[osteoporosis]]></kwd>
<kwd lng="en"><![CDATA[osteoblast]]></kwd>
<kwd lng="en"><![CDATA[osteoclast]]></kwd>
</kwd-group>
</article-meta>
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