<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422015000400005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estructura y función de la alfa-fetoproteína]]></article-title>
<article-title xml:lang="en"><![CDATA[Structure and function of the alpha-fetoprotein]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maldonado Mercado]]></surname>
<given-names><![CDATA[María Guadalupe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pereyra Morales]]></surname>
<given-names><![CDATA[Mohamed Alí]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zenteno Galindo]]></surname>
<given-names><![CDATA[Edgar Arturo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UNAM Facultad de Medicina Laboratorio 9]]></institution>
<addr-line><![CDATA[DF ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UNAM Facultad de Medicina ]]></institution>
<addr-line><![CDATA[DF ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2015</year>
</pub-date>
<volume>58</volume>
<numero>4</numero>
<fpage>5</fpage>
<lpage>13</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422015000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422015000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422015000400005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La alfa-fetoproteína es una glicoproteína que ha sido considerada como un marcador oncofetal, cuya aplicación se ha demostrado en el diagnóstico y pronóstico de enfermedades tumorales como el carcinoma hepatocelular, y también es de gran utilidad para identificar malformaciones fetales relacionadas con fallas del cierre del tubo neural y anencefalia. Diversos trabajos establecen una interesante relación entre la estructura y la función de esta proteína que permite regular la respuesta inmune de la madre y que podría participar en los eventos que evitan el rechazo del embrión. En esta revisión se identifican algunos aspectos moleculares de la alfa-fetoproteína que abren interesantes perspectivas para entender mejor su participación en el desarrollo de alteraciones tumorales.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Alpha-fetoprotein is a glycoprotein that has been considered an oncofetal marker and demonstrated its application in tumor diagnosis and prognosis of diseases such as hepatocellular carcinoma, is also useful to identify fetal malformations related to failure of neural tube closure and anencephaly. There are several works that make an interesting relationship between the structure and function of this protein that allows it to regulate the immune response of the mother and could participate in events that prevent rejection of the embryo. In this review some molecular aspects of alpha-fetoprotein that open interesting perspectives to better understand their participation in the development of tumor abnormalities are identified.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Alfa-fetoproteína]]></kwd>
<kwd lng="es"><![CDATA[hepatoma celular]]></kwd>
<kwd lng="es"><![CDATA[lectinas]]></kwd>
<kwd lng="en"><![CDATA[Alpha-fetoprotein]]></kwd>
<kwd lng="en"><![CDATA[hepatocellular]]></kwd>
<kwd lng="en"><![CDATA[lectins]]></kwd>
</kwd-group>
</article-meta>
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