<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2954-4122</journal-id>
<journal-title><![CDATA[Archivos de neurociencias (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Arch. Neurocien. (Mex.)]]></abbrev-journal-title>
<issn>2954-4122</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez"]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2954-41222025000300105</article-id>
<article-id pub-id-type="doi">10.24875/anc.24000005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Neuromarcadores predictores de neurogranina en Alzheimer preclínico mediante perceptrón multicapa]]></article-title>
<article-title xml:lang="en"><![CDATA[Neuromarkers predicting neurogranin in preclinical Alzheimer's using multilayer perceptron]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guevara-Tirado]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Científica del Sur Facultad de Medicina Humana ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Perú</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<volume>30</volume>
<numero>3</numero>
<fpage>105</fpage>
<lpage>110</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2954-41222025000300105&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2954-41222025000300105&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2954-41222025000300105&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: La neurogranina es un marcador de disfunción sináptica.  Objetivo: Predecir concentraciones de neurogranina con base en biomarcadores de neurodegenerativos en etapas preclínicas de enfermedad de Alzheimer (EA).  Método: Estudio analítico y transversal, de 367 adultos en EA preclínico. Las variables fueron: neurogranina, sinaptotagmina-1 (SYT-1), proteína asociada a sinaptosoma-25 (SNAP-25), proteína asociada al crecimiento-43 (GAP-43) y proteína beta-amiloide. Se utilizó el método de redes neuronales tipo perceptrón multicapa.  Resultados: La correlación de neurogranina con GAP-43, SNAP-25 y SYT-1 fue alta. El error relativo del perceptrón fue 0.10. En el gráfico de dispersión hubo una distribución homocedástica, con coeficiente R2 de 0.879, lo que implica que el 88% de los valores de neurogranina del líquido cefalorraquídeo puede ser explicado por los valores de neurogranina detectados indirectamente mediante GAP-43, SNAP-25 y SYT-1.  Conclusiones: La SNAP-25, la GAP-43 y la SYT-1 son fuertes predictores de concentraciones de neurogranina en EA preclínica, lo que sugiere una elevada interrelación fisiopatológica en la progresión hacia esta enfermedad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Neurogranin is a marker of synaptic dysfunction.  Objective: To predict neurogranin concentrations based on neurodegenerative biomarkers in preclinical stages of Alzheimer's disease (AD).  Method: Analytical and cross-sectional study of 367 adults in preclinical AD. The variables were: neurogranin, synaptotagmin-1 (SYT-1), synaptosome-associated protein-25 (SNAP-25), growth-associated protein-43 (GAP-43), and amyloid beta protein. Multilayer perceptron-type neural networks were used.  Results: The correlation of neurogranin with GAP-43, SNAP-25 and SYT-1 was high. The relative error of the perceptron was 0.10. In the scatter plot, there was a homoscedastic distribution, with R2 coefficient of 0.879, implying that 88% of the cerebrospinal fluid neurogranin values can be explained by the neurogranin values indirectly detected by GAP-43, SNAP-25 and SYT-1.  Conclusions: SNAP-25, GAP-43 and SYT-1 are strong predictors of neurogranin concentrations in preclinical AD, suggesting a high pathophysiological interrelation in the progression towards this disease.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Sinaptotagmina-1]]></kwd>
<kwd lng="es"><![CDATA[Neurogranina]]></kwd>
<kwd lng="es"><![CDATA[Proteína 25 asociada a sinaptosomas]]></kwd>
<kwd lng="es"><![CDATA[Proteína asociada al crecimiento neuronal]]></kwd>
<kwd lng="es"><![CDATA[Redes neurales de la computación]]></kwd>
<kwd lng="en"><![CDATA[Synaptotagmin-1]]></kwd>
<kwd lng="en"><![CDATA[Neurogranin]]></kwd>
<kwd lng="en"><![CDATA[Synaptosomal-associated protein-25]]></kwd>
<kwd lng="en"><![CDATA[Nerve growth factors]]></kwd>
<kwd lng="en"><![CDATA[Neural networks]]></kwd>
<kwd lng="en"><![CDATA[Computer]]></kwd>
</kwd-group>
</article-meta>
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