<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2954-4122</journal-id>
<journal-title><![CDATA[Archivos de neurociencias (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Arch. Neurocien. (Mex.)]]></abbrev-journal-title>
<issn>2954-4122</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez"]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2954-41222024000400146</article-id>
<article-id pub-id-type="doi">10.24875/anc.m24000019</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Revisión exploratoria sobre los tratamientos experimentales para la enfermedad de Parkinson: terapias de precisión y de amplio espectro]]></article-title>
<article-title xml:lang="en"><![CDATA[A scoping review on experimental therapeutics for Parkinson's disease: precision- and broad-targeted therapies]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres-Vásquez]]></surname>
<given-names><![CDATA[Cesarina L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero-Terán]]></surname>
<given-names><![CDATA[Diana P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Abundes-Corona]]></surname>
<given-names><![CDATA[Arturo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cervantes-Arriaga]]></surname>
<given-names><![CDATA[Amin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Violante]]></surname>
<given-names><![CDATA[Mayela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Medrano]]></surname>
<given-names><![CDATA[Ana J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Diagnóstico Medicina Avanzada y Telemedicina Unidad de Neurología y Neurocirugía ]]></institution>
<addr-line><![CDATA[Santo Domingo ]]></addr-line>
<country>República Dominicana</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez Laboratorio Clínico de Enfermedades Neurodegenerativas ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez Clínica de Trastornos del Movimiento ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,University of Maryland Programa de Maestría en Estudios Profesionales (MPS) en Ciencias de Datos ]]></institution>
<addr-line><![CDATA[Baltimore ]]></addr-line>
<country>EE.UU</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>29</volume>
<numero>4</numero>
<fpage>146</fpage>
<lpage>160</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2954-41222024000400146&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2954-41222024000400146&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2954-41222024000400146&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La enfermedad de Parkinson (EP) se caracteriza por una heterogeneidad clínica y una etiopatogenia multifactorial. Si bien el enfoque convencional para el cuidado de las y los pacientes se centra en el manejo sintomático, las estrategias más recientes proponen métodos para proteger las neuronas dopaminérgicas al dirigirse a vías moleculares específicas. Estos medicamentos experimentales se clasifican en: (1) de precisión o de amplio espectro según su mecanismo de acción, (2) nuevas formulaciones antiparkinsonianas y (3) de reposicionamiento. Esta revisión narrativa resumirá los aspectos más relevantes de las terapias de precisión y de amplio espectro más actuales. Se realizó una búsqueda exhaustiva de la literatura en PubMed para recopilar la evidencia sobre los medicamentos experimentales en la EP, abarcando el periodo 2013 a 2023. Además, se revisó el registro de ensayos clínicos ClinicalTrials.gov. Se están investigando diversas estrategias potencialmente neuroprotectoras, incluyendo fármacos dirigidos a vías moleculares implicadas en la patogénesis de la EP, centrándose en inhibir la agregación de alfa-sinucleína mal plegada. Asimismo, se están explorando terapias dirigidas a mitocondrias, lisosomas y estrés oxidativo debido a su papel en la salud y supervivencia neuronal. Los blancos de precisión, como ciertas proteínas, se están investigando mediante terapias génicas, anticuerpos monoclonales, inhibidores de cinasas y moléculas pequeñas. Muchos de estos tratamientos se encuentran todavía en fases tempranas de desarrollo y su seguridad y eficacia a largo plazo aún no se han establecido. El panorama de las terapias experimentales genera optimismo para lograr mejores resultados y calidad de vida para quienes viven con EP.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Parkinson's disease (PD) is a neurodegenerative disorder characterized by clinical heterogeneity and multifactorial etiopathogenesis. Although the conventional approach to patient care primarily emphasizes managing symptoms using dopaminergic drugs, newer strategies propose methods to protect dopaminergic neurons by targeting molecular pathways. These experimental medications are here as (1) precisionor broad-targeted therapies according to their mechanism of action, (2) new antiparkinsonian formulations, and (3) repurposed drugs. This narrative review will summarize the most relevant aspects of up-to-date precisionor broad-targeted therapies. A comprehensive literature search of PubMed was performed, to summarize the current evidence regarding experimental medications in PD, between 2013 and 2023. In addition, ClinicalTrials.gov was revised. Several potential neuroprotective strategies are under investigation, including drugs targeting specific molecular pathways implicated in PD pathogenesis. Research is focused on inhibiting the aggregation of misfolded alpha-synuclein, a key protein associated with PD. In addition, therapies targeting mitochondria, lysosomes, and oxidative stress are being explored due to their involvement in neuronal health and survival. Precision targets, including proteins are explored through gene therapies, monoclonal antibodies, kinase inhibitors, and small molecules. Many experimental drugs are still in the early phases of development, and their long-term safety and efficacy are yet to be established. The evolving landscape of experimental therapeutics instills optimism for improved outcomes and enhanced quality of life for individuals grappling with PD.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Enfermedad de Parkinson]]></kwd>
<kwd lng="es"><![CDATA[Terapias en investigación]]></kwd>
<kwd lng="es"><![CDATA[Terapia molecular dirigida]]></kwd>
<kwd lng="es"><![CDATA[Reposicionamiento de fármacos]]></kwd>
<kwd lng="es"><![CDATA[Agentes antiparkinsonianos]]></kwd>
<kwd lng="es"><![CDATA[Medicina de precisión]]></kwd>
<kwd lng="en"><![CDATA[Parkinson disease]]></kwd>
<kwd lng="en"><![CDATA[Investigational therapies]]></kwd>
<kwd lng="en"><![CDATA[Molecular targeted therapy]]></kwd>
<kwd lng="en"><![CDATA[Drug repositioning]]></kwd>
<kwd lng="en"><![CDATA[Antiparkinson agents]]></kwd>
<kwd lng="en"><![CDATA[Precision medicine]]></kwd>
</kwd-group>
</article-meta>
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