<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2954-4122</journal-id>
<journal-title><![CDATA[Archivos de neurociencias (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Arch. Neurocien. (Mex.)]]></abbrev-journal-title>
<issn>2954-4122</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez"]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2954-41222021000200026</article-id>
<article-id pub-id-type="doi">10.31157/archneurosciencesmex.v26i2.265</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Germinoma with diffuse subependymal quadriventricular, cerebellar, and rostral brainstem spread. Case report]]></article-title>
<article-title xml:lang="es"><![CDATA[Germinoma con diseminación difusa subependimaria cuadriventricular, cerebelar y tallo cerebral rostral. Reporte de caso]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villarreal-García]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Contreras-Guerrero]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fragoza-Sánchez]]></surname>
<given-names><![CDATA[Edgar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quiñones-González]]></surname>
<given-names><![CDATA[Alba Monserrat]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Juárez]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medina-Romero]]></surname>
<given-names><![CDATA[José Raymundo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Secretaría de Salud  ]]></institution>
<addr-line><![CDATA[ Durango]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Secretaría de Salud  ]]></institution>
<addr-line><![CDATA[ Durango]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Secretaría de Salud  ]]></institution>
<addr-line><![CDATA[ Durango]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>26</volume>
<numero>2</numero>
<fpage>26</fpage>
<lpage>29</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2954-41222021000200026&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2954-41222021000200026&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2954-41222021000200026&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: germinoma of the central nervous system have a predilection for the midline, the differential diagnosis is broad, immunohistochemistry determines the definitive diagnosis. Clinical case: a 19-yearold male begins with double vision when staring or following objects, bilateral frontal headache, without radiation, stabbing. Decreased visual acuity was added, with third cranial nerve palsy to conjugated gaze supraversion, absent Babinski, intention tremor, ataxic gait to TANDEM and dizziness when performing it. Upon admission; clinical diagnosis, cerebellar verm syndrome; imaging diagnosis, likely primary brain lymphoma and non-communicating hydrocephalus; surgical management, placement of the right precoronal point, ventriculo-peritoneal shunt valve, and sampling of cerebrospinal fluid; tumor markers, negative; pharmacological management, ceftriaxone and albendazole; incisional biopsy due to left parietal stereotactic surgery, intraoperative biopsy, lymphoid atypia; histopathological diagnosis, neoplastic lesion; immunohistochemical diagnosis, germinoma.  Conclusion: this is the first described case of a midline germinoma with diffuse subependymal quadriventricular, cerebellar and rostral brain stem spread.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Introducción: los germinomas del sistema nervioso central tienen predilección por la línea media, el diagnóstico diferencial es amplio y la inmunohistoquímica determina el diagnóstico definitivo. Caso clínico: adolescente de 19 años, inicia con visión doble al fijar la mirada o seguir objetos, cefalea frontal bilateral, sin irradiación, punzante. Se agregó disminución de agudeza visual, con parálisis del III nervio craneal a la supraversión conjugada de la mirada, Babinski ausente, temblor de intención, marcha atáxica al TANDEM y mareo al realizarlo. Al ingreso; diagnóstico clínico, síndrome cerebeloso vermiano; diagnóstico imagenológico, probable linfoma cerebral primario e hidrocefalia no comunicante; manejo quirúrgico, colocación de VDVP punto precoronal derecho y toma de muestra de líquido cefalorraquídeo; marcadores tumorales, negativos; manejo farmacológico, ceftriaxona y albendazol; biopsia incisional por esterotaxia parietal izquierda, transoperatorio, atipia linfoide; diagnóstico histopatológico, lesión neoplásica; diagnóstico inmunohistoquímico, germinoma.  Conclusión: se presentó el primer el caso descrito de germinoma de línea media con extensión difusa subependimaria cuadriventricular, cerebelar y tallo cerebral rostral.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[germinoma]]></kwd>
<kwd lng="en"><![CDATA[immunohistochemistry]]></kwd>
<kwd lng="en"><![CDATA[quadriventricular]]></kwd>
<kwd lng="en"><![CDATA[subependymal]]></kwd>
<kwd lng="en"><![CDATA[tumor marker]]></kwd>
<kwd lng="es"><![CDATA[cuadriventricular]]></kwd>
<kwd lng="es"><![CDATA[germinoma]]></kwd>
<kwd lng="es"><![CDATA[inmunohistoquímica]]></kwd>
<kwd lng="es"><![CDATA[marcador tumoral]]></kwd>
<kwd lng="es"><![CDATA[subependimario]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Louis]]></surname>
<given-names><![CDATA[DN]]></given-names>
</name>
<name>
<surname><![CDATA[Ohgaki]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Wiestler]]></surname>
<given-names><![CDATA[OD]]></given-names>
</name>
<name>
<surname><![CDATA[Cavenee]]></surname>
<given-names><![CDATA[WK]]></given-names>
</name>
<name>
<surname><![CDATA[Burger]]></surname>
<given-names><![CDATA[PC]]></given-names>
</name>
<name>
<surname><![CDATA[Jouvet]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Scheithauer]]></surname>
<given-names><![CDATA[BW]]></given-names>
</name>
<name>
<surname><![CDATA[Kleihues]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The 2007 WHO classification of tumours of the central nervous system]]></article-title>
<source><![CDATA[Acta Neuropathol]]></source>
<year>2007</year>
<volume>114</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>97-109</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lieuw]]></surname>
<given-names><![CDATA[KH]]></given-names>
</name>
<name>
<surname><![CDATA[Haas-Kogan]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Ablin]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intracranial germ cell tumors. in: Gupta N., Banerjee A., Haas-Kogan D. (eds) Pediatric CNS tumors. Pediatric Oncology]]></article-title>
<source><![CDATA[Springer, Berlin, Heidelberg]]></source>
<year>2004</year>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Krueger]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
<name>
<surname><![CDATA[Invergo]]></surname>
<given-names><![CDATA[DL]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[JJ.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Germinoma with diffuse subependymal spread: acase report]]></article-title>
<source><![CDATA[Cureus]]></source>
<year>2016</year>
<volume>8</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Suresh]]></surname>
<given-names><![CDATA[TN]]></given-names>
</name>
<name>
<surname><![CDATA[Mahadevan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Santosh]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Shankar]]></surname>
<given-names><![CDATA[SK.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Subarachnoid spread of germinoma mimicking tuberculous meningitis]]></article-title>
<source><![CDATA[Neurology India]]></source>
<year>2004</year>
<volume>52</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>251-3</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Jagjivan]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Rao]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Germinoma-unusual presentation: a case report]]></article-title>
<source><![CDATA[Conn Med]]></source>
<year>2004</year>
<volume>68</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>617-9</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Félix]]></surname>
<given-names><![CDATA[IA.]]></given-names>
</name>
</person-group>
<source><![CDATA[Atlas de neuropatología]]></source>
<year>2000</year>
<page-range>41-51</page-range><publisher-loc><![CDATA[México ]]></publisher-loc>
<publisher-name><![CDATA[Editorial Auroch]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[David]]></surname>
<given-names><![CDATA[N. Louis]]></given-names>
</name>
<name>
<surname><![CDATA[Ohgaki]]></surname>
<given-names><![CDATA[Hiroko]]></given-names>
</name>
<name>
<surname><![CDATA[Otmar]]></surname>
<given-names><![CDATA[D. Wiestler]]></given-names>
</name>
<name>
<surname><![CDATA[Webster]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cavenee (Eds):WHO Classification of tumours of the central nervous system (revised 4th edition)]]></article-title>
<source><![CDATA[IARC]]></source>
<year>2016</year>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
