<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2696-130X</journal-id>
<journal-title><![CDATA[Revista mexicana de angiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. angiol.]]></abbrev-journal-title>
<issn>2696-130X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Angiología, Cirugía Vascular y Endovascular A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2696-130X2021000400113</article-id>
<article-id pub-id-type="doi">10.24875/rma.21000040</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Angiotensin II receptor blockers as a risk factor for skin ulcers]]></article-title>
<article-title xml:lang="es"><![CDATA[Bloqueadores de angiotensina II como factor de riesgo para úlceras cutáneas]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Fregoso]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leo-Amador]]></surname>
<given-names><![CDATA[Guillermo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cardona-Cabrera]]></surname>
<given-names><![CDATA[Román]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Gil]]></surname>
<given-names><![CDATA[Lourdes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,San Luca Centro Vascular Research Department ]]></institution>
<addr-line><![CDATA[ Querétaro]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>49</volume>
<numero>4</numero>
<fpage>113</fpage>
<lpage>116</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2696-130X2021000400113&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2696-130X2021000400113&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2696-130X2021000400113&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective: The aim of the study was to determine the risk factors associated with skin ulcers that were not of vascular, paraneoplastic, rheumatologic, or pressure origin.  Methods: This was an observational, case- and control-designed, and retrospective trial. The group of cases was patients who presented skin ulcers that were not of vascular, paraneoplastic, or pressure origin. The control group was formed by ill subjects with no skin ulcers paired in age, sex, and chronic diseases. The cases were defined with the presence of an ulcer, at the 1st time consultation; treatment with medication, symptoms, progression time, and substance abuse were entered in a database. The statistical analysis of the results was performed using the EpiInfo software, version 7.2.2.6.  Results: Between July 2005 and December 2020, 69 patients suffering from skin ulcers without apparent etiology were enrolled. Following the statistical analysis of all variables, a significant difference in favor of the cases with antihypertensive treatment with angiotensin II receptor blockers (ARBs) was obtained, with p &#8804; 0.02 and odds ratio 2.24 with confidence interval 95 % (1.1–4.5).  Conclusion: ARB medications are a risk factor for the presence of skin ulcers.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo: Determinar los factores de riesgo que se asocian a úlceras cutáneas que no fueran de origen vascular, paraneoplásico, reumatológicas o por presión.  Métodos: Estudio observacional con diseño de casos y controles, retrospectivo. El grupo de casos fueron pacientes que presentaban úlceras cutáneas que no fueran de origen vascular, paraneoplásico, reumatológicas o por presión. El grupo control se integró con enfermos sin úlceras cutáneas pareados por edad, sexo y enfermedades crónicas. Se definieron los casos con presencia de úlcera en la consulta de primera vez. Se capturó en una base de datos el tratamiento con medicamentos, los síntomas, el tiempo de evolución y las toxicomanías. El análisis estadístico de los resultados se realizó utilizando el programa de EpiInfo versión 7.2.2.6.  Resultados: Entre julio del 2005 y diciembre del 2020 se registraron 69 pacientes con úlceras cutáneas sin etiología aparente. Después del análisis estadístico de todas las variables se obtuvo una diferencia significativa en favor de los casos con tratamiento antihipertensivos con antagonistas de los receptores de la angiotensina II (ARA II), con p &lt; 0. 02 y razón de momios 2.24 (intervalo de confianza del 95%: 1.1-4.5).  Conclusiones: Los medicamentos tipo ARA II son un factor de riesgo para la presencia de úlcera cutáneas.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Skin ulcers]]></kwd>
<kwd lng="en"><![CDATA[Angiotensin II receptor blockers]]></kwd>
<kwd lng="en"><![CDATA[Nonvascular ulcers]]></kwd>
<kwd lng="es"><![CDATA[Úlceras cutáneas]]></kwd>
<kwd lng="es"><![CDATA[ARA II]]></kwd>
<kwd lng="es"><![CDATA[Úlceras no vasculares]]></kwd>
</kwd-group>
</article-meta>
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