<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2696-1296</journal-id>
<journal-title><![CDATA[Revista mexicana de medicina familiar]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Mex. med. familiar]]></abbrev-journal-title>
<issn>2696-1296</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Especialistas y Residentes en Medicina Familiar A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2696-12962025000200004</article-id>
<article-id pub-id-type="doi">10.24875/rmf.25000024</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Ginecomastia por hipogonadismo en el varón adulto. Un problema emergente asociado a mayor mortalidad]]></article-title>
<article-title xml:lang="en"><![CDATA[Gynecomastia due to hypogonadism in adult male. An emerging problem associated with higher mortality]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Redondo-Mayordomo]]></surname>
<given-names><![CDATA[Raquel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín-Moreno]]></surname>
<given-names><![CDATA[Vicente]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín-Fernández]]></surname>
<given-names><![CDATA[Amanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Mateos]]></surname>
<given-names><![CDATA[Asunción]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Servicio Madrileño de Salud  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Polibea Concierto Centro de Rehabilitación de Daño Cerebral ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>12</volume>
<numero>2</numero>
<fpage>59</fpage>
<lpage>68</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2696-12962025000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2696-12962025000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2696-12962025000200004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La ginecomastia es un motivo de consulta emergente en atención primaria. En varones jóvenes (25-65 años) es probable una patología subyacente, como el hipogonadismo. El estudio del hipogonadismo debe recoger antecedentes personales (tratamientos, cirugías y traumatismos) y familiares, cronología del desarrollo de la ginecomastia, síntomas que ocasiona e historia sexual (inicio de la pubertad, erecciones matutinas y ante estímulo, libido). También debe incluir exploración de las mamas, descartando galactorrea; exploración genital (tamaños de pene y de testículos); presencia y distribución del vello corporal, axilar y púbico; y distribución de la grasa corporal, que orientarán sobre el diagnóstico. La determinación analítica de FSH, LH y testosterona confirmará un hipogonadismo, que puede ser hiper- o hipogonadotrófico. En caso de hipogonadismo, se recomienda realizar seminograma, densitometría y estudio genético, complementados con ecografía testicular. El tratamiento de reemplazo con testosterona mejora la clínica, pero tiene efectos limitados sobre la fertilidad, requiriendo seguimiento del hematocrito y vigilancia de la próstata y las mamas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Gynecomastia is an emerging cause of consultation in primary care. In young men (25-65 years) it is likely to have an underlying pathology, such as hypogonadism. The study of hypogonadism should include personal history (treatments, surgeries and trauma) and family history, chronology of the development of gynecomastia, symptoms it causes, and sexual history (onset of puberty, morning and stimulated erections, libido). Also breast exploration, ruling out galactorrhea; genital (penis and testicular size); presence and distribution of body hair, axillary and pubic; and body fat, which will guide the diagnosis. The analytical determination of FSH, LH, and testosterone will confirm hypogonadism, which can be hyper- or hypogonadotrophic. In the presence of hypogonadism, it is recommended to perform seminogram, densitometry and genetic study, complemented with testicular ultrasound. Testosterone replacement therapy improves the clinical symptoms, but has limited effects on fertility, requiring hematocrit monitoring, and prostate and breast monitoring.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ginecomastia]]></kwd>
<kwd lng="es"><![CDATA[Hipogonadismo]]></kwd>
<kwd lng="es"><![CDATA[Síndrome de deficiencia de testosterona]]></kwd>
<kwd lng="es"><![CDATA[Azoospermia]]></kwd>
<kwd lng="es"><![CDATA[Testosterona]]></kwd>
<kwd lng="en"><![CDATA[Gynecomastia]]></kwd>
<kwd lng="en"><![CDATA[Hypogonadism]]></kwd>
<kwd lng="en"><![CDATA[Testosterone deficiency syndrome]]></kwd>
<kwd lng="en"><![CDATA[Azoospermia]]></kwd>
<kwd lng="en"><![CDATA[Testosterone]]></kwd>
</kwd-group>
</article-meta>
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