<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2604-1227</journal-id>
<journal-title><![CDATA[Revista mexicana de oftalmología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. oftalmol]]></abbrev-journal-title>
<issn>2604-1227</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Oftalmología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2604-12272021000200063</article-id>
<article-id pub-id-type="doi">10.24875/rmo.m20000146</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Ensayo clínico de insulina tópica y hialuronato sódico en el tratamiento del defecto epitelial producido por el desbridamiento corneal transquirúrgico durante la vitrectomía vía pars plana en diabéticos]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical trial of topical insulin and sodium hyaluronate in the treatment of epithelial defects produced by intraoperative corneal epithelial debridement during pars plana vitrectomy in diabetics]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quiroz-Mendoza]]></surname>
<given-names><![CDATA[Jaime L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Roa]]></surname>
<given-names><![CDATA[Marlon]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero-Morales]]></surname>
<given-names><![CDATA[Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valera-Cornejo]]></surname>
<given-names><![CDATA[Diego]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vázquez-Membrillo]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-Neria]]></surname>
<given-names><![CDATA[Paulina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villalpando-Gómez]]></surname>
<given-names><![CDATA[Yolanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Franco]]></surname>
<given-names><![CDATA[Renata]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano de Oftalmología Departamento de Retina y Vítreo ]]></institution>
<addr-line><![CDATA[Querétaro ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<volume>95</volume>
<numero>2</numero>
<fpage>63</fpage>
<lpage>70</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2604-12272021000200063&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2604-12272021000200063&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2604-12272021000200063&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo: Comparar el efecto de la insulina tópica y del hialuronato sódico en el cierre del defecto epitelial producido por el desbridamiento corneal transquirúrgico durante la vitrectomía vía pars plana en diabéticos.  Método:: Ensayo clínico controlado. Los pacientes fueron aleatorizados a uno de tres grupos de tratamiento: hialuronato sódico tópico al 0.15% (grupo I), insulina tópica 0.5 UI/gota (grupo II) o tratamiento combinado con insulina 0.5 UI/gota y hialuronato sódico tópicos al 0.15% (grupo III).  Resultados: Se incluyeron 36 ojos de 36 pacientes, 12 ojos en cada grupo. No hubo diferencias estadísticamente significativas en las características basales. El tiempo necesario hasta la reepitelización completa fue de 4.25 ± 0.62, 3.0 ± 0.85 y 3.33 ± 0.98 días en los grupos I, II y III, respectivamente, presentado el grupo II un tiempo de reepitelización significativamente menor (p &lt; 0.001). En todos los grupos se redujo el área del defecto epitelial a partir del día 1, con una menor área en el grupo II; sin embargo, esta diferencia no fue estadísticamente significativa en comparación con los otros grupos. No se reportaron efectos adversos.  Conclusiones: La insulina tópica y el tratamiento combinado de insulina tópica y hialuronato sódico son efectivos para el cierre de defectos epiteliales después del desbridamiento corneal transquirúrgico en diabéticos. La insulina tópica y el tratamiento combinado de esta con hialuronato sódico tienen un mayor efecto que el tratamiento solo con hialuronato sódico. El tratamiento con insulina y el tratamiento combinado demostraron ser seguros y bien tolerados.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Purpose: To compare the effect of topical insulin and sodium hyaluronate in the treatment of epithelial defects secondary to intraoperative corneal epithelial debridement during pars plana vitrectomy in diabetics.  Methods: Controlled clinical trial. Patients were randomized to one of three treatment groups: topical 0.15% sodium hyaluronate (group I), topical insulin 0.5 IU/drop (group II) or combined treatment with topical insulin 0.5 IU/drop and 0.15% sodium hyaluronate (group III).  Results: Thirty-six eyes of 36 patients were included, 12 eyes in each group. There were no statistically significant differences in baseline characteristics. The time required until complete re-epithelialization was of 4.25 ± 0.62, 3.0 ± 0.85 and 3.33 ± 0.98 days, in groups I, II and III, respectively; group II showed a significantly shorter reepithelialization time (p &lt;0.001). All groups had a reduction in the area of the epithelial defect from day 1; a smaller area was observed in group II; however, this difference was not statistically significant. No adverse effects were reported.  Conclusions: Both topical insulin and combined treatment with topical insulin and sodium hyaluronate are effective to treat corneal epithelial defects secondary to intraoperative corneal epithelial debridement during pars plana vitrectomy in diabetics. The addition of sodium hyaluronate to topical insulin did not provide a greater benefit. The three treatments were safe and well tolerated.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Diabetes mellitus]]></kwd>
<kwd lng="es"><![CDATA[Epitelio corneal]]></kwd>
<kwd lng="es"><![CDATA[Hialuronato sódico]]></kwd>
<kwd lng="es"><![CDATA[Insulina]]></kwd>
<kwd lng="es"><![CDATA[Retinopatía diabética]]></kwd>
<kwd lng="es"><![CDATA[Vitrectomía]]></kwd>
<kwd lng="en"><![CDATA[Diabetes mellitus]]></kwd>
<kwd lng="en"><![CDATA[Corneal epithelium]]></kwd>
<kwd lng="en"><![CDATA[Sodium hyaluronate]]></kwd>
<kwd lng="en"><![CDATA[Insulin]]></kwd>
<kwd lng="en"><![CDATA[Diabetic retinopathy]]></kwd>
<kwd lng="en"><![CDATA[Vitrectomy]]></kwd>
</kwd-group>
</article-meta>
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