<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2565-005X</journal-id>
<journal-title><![CDATA[Gaceta mexicana de oncología]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. mex. oncol.]]></abbrev-journal-title>
<issn>2565-005X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Oncología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2565-005X2025000200002</article-id>
<article-id pub-id-type="doi">10.24875/j.gamo.24000066</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Transcriptomic differences of leukemic stem cells with profiles CD99 high and t(8;21)]]></article-title>
<article-title xml:lang="es"><![CDATA[Diferencias transcriptómicas de células madre leucémicas con perfiles CD99 alto y t(8;21)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zapata-García]]></surname>
<given-names><![CDATA[Jessica A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Guadalajara Deanship of Health Sciences School of Medicine]]></institution>
<addr-line><![CDATA[Zapopan ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>24</volume>
<numero>2</numero>
<fpage>51</fpage>
<lpage>59</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2565-005X2025000200002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2565-005X2025000200002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2565-005X2025000200002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Leukemic stem cells (LSC) are characterized by excessive proliferation, self-renewal capacity, and chemoresistance, these attributes contribute to the complexity of leukemia treatment.  Objective: To identify differences in the transcriptome of two LSC profiles.  Methods: RNA sequencing analysis was conducted on CD99 high and t(8;21) LSC profiles, with the results subsequently correlated with the overall survival of patients with myeloid leukemia.  Results: The CD99 high profile was found to be regulated by senescence mechanisms, RNA modulation, WNT, RHO GTPASES, and interleukin 7 signaling pathways, whereas the t(8;21) cells by small molecule transport, RNA polymerase II, and G protein alpha and GPCR-mediated signaling pathways. Furthermore, high expression of 19 genes of the t(8;21) profile and 4 of the high CD99 profile correlated with poor survival in patients with myeloid leukemia treated with chemotherapy.  Conclusion: This study provides novel information leading to the conclusion that the LSC profiles analyzed in this work exhibit divergent transcriptomic regulation that may benefit chemoresistant capacity in the context of myeloid leukemia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: Las células madre leucémicas se caracterizan por una proliferación excesiva, capacidad de autorrenovación y quimiorresistencia, lo que dificulta el tratamiento de la leucemia.  Objetivo: Identificar diferencias en el transcriptoma de dos perfiles de células madre leucémicas.  Método:: Se realizó análisis de secuenciación de ARN de los perfiles de células madre leucémicas CD99 alto y t(8;21), como también correlación de esos resultados con la supervivencia general de pacientes con leucemia mieloide.  Resultados: Se encontró que el perfil CD99 alto presenta regulación mediada por mecanismos de senescencia, modulación de ARN, las vías de señalización WNT, RHO GTPASES e interleucina 7, mientras que las células t(8;21) por transporte de moléculas pequeñas, ARN polimerasa II y vías de señalización mediadas por proteínas G alfa y GPCR. Además, la expresión alta de 19 genes del perfil t(8;21) y cuatro del perfil high-CD99 se correlacionó con una supervivencia pobre en pacientes con leucemia mieloide tratados con quimioterapia.  Conclusión:: Este estudio aporta información novedosa que permite concluir que los perfiles de células madre leucémicas analizadas en este trabajo presentan regulación transcriptómica divergente que puede beneficiar la capacidad quimiorresistente en el contexto de la leucemia mieloide.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Leukemic stem cells]]></kwd>
<kwd lng="en"><![CDATA[CD99]]></kwd>
<kwd lng="en"><![CDATA[t(8;21)]]></kwd>
<kwd lng="en"><![CDATA[Chemoresistance]]></kwd>
<kwd lng="en"><![CDATA[Prognosis]]></kwd>
<kwd lng="es"><![CDATA[Células madre leucémicas]]></kwd>
<kwd lng="es"><![CDATA[CD99]]></kwd>
<kwd lng="es"><![CDATA[t(8;21)]]></kwd>
<kwd lng="es"><![CDATA[Quimiorresistencia]]></kwd>
<kwd lng="es"><![CDATA[Pronóstico]]></kwd>
</kwd-group>
</article-meta>
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